Newsbriefs Medical News --------------------------------- Scientists track 'molecular terrorists' found in lupus --------------------------------- Like detectives tracking a terrorist, Hopkins scientists have identified the cause of lupus flareups by figuring out its method of destruction. Discovering this strategic factor in apoptosis--cells' built-in "suicide" program--suggests a treatment could be created around stopping this step in the process, the scientists said. The insight may also shed light on other disorders that involve programmed cell death, such as arthritis and heart disease. Comparing the process to placing strategically a few explosives to implode a building instead of scattering them randomly, the scientists say the culprit in lupus flareups is an enzyme necessary for normal cell death. But in lupus, the enzyme sets up too many cells for destruction--a kind of fanatical demolitions expert targeting buildings that should be left alone. "Our next step is determining how to block the enzyme responsible for the cell death involved in lupus flareups, which can be triggered by sunlight and viral infections," said Antony Rosen, the study's senior author and an assistant professor of medicine. The findings are published in the December issue of the Journal of Experimental Medicine. -------------------------------- New gene therapy for cystic fibrosis tested -------------------------------- A human gene therapy trial for cystic fibrosis has been established by Hopkins scientists in conjunction with Targeted Genetics Corp., a Seattle-based biotechnology firm. The project marks the first time an adeno-associated virus--a harmless virus normally found in the body--will be used to ferry normal copies of genes into the DNA of cells lining the nose and lungs. Cystic fibrosis--affecting nearly 30,000 adults and children in the United States--is caused by defects in a gene called CFTR, which hamper a protein from pumping salt and water across cells to make thin, fluid mucous. Symptoms include severe lung disease, sinus infections and pancreatic problems. Although antibiotics and medicines that clear the lungs of abnormal mucus have increased life expectancy, no cure yet exists. "We hope the AAV transport system, or vector, will have long-lasting effects without causing harmful inflammation," said Terence Flotte, assistant professor of pediatrics and co-developer of the vector. "We don't know yet if the AAV vector will allow therapeutic amounts of the protein to be produced, but laboratory and animal studies indicate it is capable of doing so," said William Guggino, director of the Hopkins Gene Therapy Center. -------------------------------- Vaccinating mothers shown to benefit infants -------------------------------- A recent study by researchers at the School of Public Health concluded that vaccinating pregnant women against pneumococcal infection offered a significant increase in protection for their infants for up to five months. Not only was the level of antibodies in these infants two to three times higher than in the average adult, but at five months the babies--as well as their mother's breast milk--still had above-average amounts of antibodies. The study's principal investigator, associate professor of international health Mark Steinhoff, believes the findings, which were published in the Nov. 11 issue of Lancet, may also have implications for passive protection against group B strep, a common infection of infants in the United States. --------------------------------- India faces major AIDS burden by decade's end --------------------------------- In the first study of its kind in India, researchers from Hopkins and the National AIDS Research Institute in India have found evidence there of one of the highest rates of HIV transmission ever reported. The findings support the warning by the World Health Organization that India may face the largest burden of HIV infection of any country in the world by the end of this decade. WHO currently estimates that India has more than 1.5 million HIV-infected persons. The study was done because the researchers previously found that, by 1993, one-fifth of patients at STD clinics in the city of Pune were already infected with HIV. "Although India has many important public health problems, it's particularly important to study the AIDS epidemic there, especially because it might worsen other public health problems, such as tuberculosis," said Robert Bollinger, assistant professor of infectious diseases. "But we hope that our findings will help researchers design programs for slowing the rate of infection in India. This is especially important because there is no effective vaccine available yet." Other News -------------------------------- United Way campaign surpasses 1995 goal -------------------------------- The university and hospital have reached 99.8 percent of their combined goal of $800,700 in the 1995 Hopkins United Way campaign. Campaign chairman Dean Don Giddens congratulates university faculty and staff on exceeding their goal of $573,700, reaching $583,228 in pledges as of Dec. 1. Of the 167 members of the chairman's club--those pledging $1,000 or more--46 are new members. Campaign contributions can be made throughout the year. ------------------------------- Former president to speak at commencement ------------------------------- Former president George Bush has accepted the Homewood senior class's invitation to be their commencement speaker at ceremonies scheduled for the afternoon of May 22. Bush was president from 1988 to 1992.