Systems Biology Laboratory


New research shows the critical role of lymphatic vessels in cancer and metastasis
Sept 2, 2014 'Prepped' by tumor cells, lymphatic cells encourage breast cancer cells to spread. HIV drug plus blood vessel growth-blockers could halt metastasis.

Johns Hopkins researchers discover that an FDA-approved HIV drug may be useful in treating breast cancer metastasis.

Sept 3, 2014 Tumor Cells May Encourage Lymphatic Cells to Spread Breast Cancer - And a New Treatment Could Stop It.

Breast Cancer News

Sept 3, 2014 GEN Genetic Engineering & Biotechnology News. Lymphatic Cells Shill for Breast Cancer.


Sept 6, 2014


Cover Page in Microvascular Research for the entire year 2014

Hispanic (October 25, 2013)

“Researchers from Johns Hopkins University School of Medicine Report on Findings in Angiogenesis”

Highlights in The Washington Post (October 4, 2013)

“Collaboration with the Johns Hopkins Carey Business School and the Discovery to Market technology transfer course on developing treatments for AMD”

Treatment of central vision loss (September 6, 2013)

“BME researchers testing promising drug therapy delivery method for improved treatment of central vision loss"

Drug Deliver Pharmaceutical (August 22, 2013)

“Johns Hopkins’ biomedical engineers to create therapeutic eye injections”\

Hispanic (August 21, 2013)

“Time-release coating allows drug for macular degeneration to last longer”

FierceDrugDelivery (August 20, 2013)

“Time-release delivery of vision-loss drug demands fewer injections.”

Hopkins Medicine (August 19, 2013)

“Therapeutic eye injections may be needed less often”

Our lab work was featured in the article "Creating accurate models of life" in IEEE pulse, March/April 2013

”In my opinion, computational systems biology, including multiscale modeling, will be at the forefront of the transformation of medicine, a process that has just begun,” commented by Dr. Aleksander S. Popel. Stacey Finley and Lawrence Chu's work contributes Fig. S1 and S2, respectively. pdf dowload

Kerri-Ann Norton was awarded an American Cancer Society Postdoctoral Fellowship

She received this award for the topic "Computational Modeling of Tumor-Induced Angiogenesis". Congratulations!

Spyros Stamatelos selected to receive 2013 MCS John R. Pappenheimer Postdoctoral Travel Award

November 2012 Special Issue: Multiscale Systems Biology Cover: Schematic illustrating “multiscale” imaging of the angiogenic phenotype. From: Eugene Kim, Spyros Stamatelos, Jana Cebulla, Zaver M. Bhujwalla, Aleksander S. Popel, and Arvind P. Pathak.


Spyros Stamatelos honored at INBT research symposium

Spyros Stamatelos was first author with Eugene Kim, Arvind Pathak and Aleksander Popel on the poster Characterization of the Heterogeneity of Tumor Vasculature using Hemodynamic Modeling and High Resolution Imaging Implications for Drug Delivery.

Esak Lee honored at 5th Annual Safeway Breast Cancer Retreat, the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University

"Runner Up" Poster Award was presented to Esak Lee who was first author with Niranjan Pandey and Aleksander Popel on the poster titled "Lymphatic endothelial cells (LEC) induce angiogenesis in axillary and brachial lymph nodes in breast cancer."

Stacey Finley selected to receive conference travel award

A travel award was presented to Stacey Finley to attend the SIAM (Society of Industrial and Applied Mathematics) Life Sciences Conference in San Diego, August 7-10, 2012. Stacey will give an oral presentation entitled "Multiscale modeling of breast cancer angiogenesis with therapeutic applications". Dr. Aleksander Popel is senior author on the abstract.

Practical Applications of Systems Biology Approach Provides New Perspectives for Biomedical Science Research Initiatives

Genetic Engineering & Biotechnology News, May 1, 2009. Click here for more information

A couple of press items on our paper in PNAS, see below:

from Pharmaceutical Executive: Click here
from Johns Hopkins Newsletter: Click here


Three journal covers from our recent papers:

Physiological Genomics, June 6, 2009, Click here for more information

Nitric Oxide, Volume 20, Issue 4, 2008, click here for more information

Antioxidants and Redox Signaling, Volume 10,Number 7, 2008, Click here for more information.