Publications
Nodelman I.M.*, Das S.*, Faustino A.M., Fried S.D., Bowman G.D.#, Armache J-P.# (2022) Nucleosome recognition and DNA distortion by the Chd1 remodeler in a nucleotide-free state. Nat Struct Mol Biol. 29:121-129. *co-first; #co-corresponding [PubMed] [PDF]
Ghassabi Kondalaji S, Bowman G.D. (2022) Reb1, Cbf1, and Pho4 Bias Histone Sliding and Deposition Away from Their Binding Sites. Mol Cell Biol. 42(2):e0047221. [Pubmed]
[2021]Nodelman I.M. & Bowman G.D. (2021) Biophysics of Chromatin Remodeling. Annu Rev Biophys. 50:73-93. [Annual Reviews]
Nodelman I.M., Shen Z., Levendosky R.F., Bowman G.D. (2021) Autoinhibitory elements of the Chd1 remodeler block initiation of twist defects by destabilizing the ATPase motor on the nucleosome. Proc Natl Acad Sci U S A. 118(4):e2014498118. [Pubmed]
[2020]Nodelman I.M., Patel A., Levendosky R.F., Bowman G.D. (2020) Reconstitution and Purification of Nucleosomes with Recombinant Histones and Purified DNA. Curr Protoc Mol Biol. 133(1):e130. [Pubmed]
[2019]Ren R., Kondalaji S.G., Bowman G.D. (2019) The Chd1 chromatin remodeler forms long-lived complexes with nucleosomes in the presence of ADP•BeF3- and transition state analogs. J Biol Chem, 294(48):18181-18191. [Pubmed]
Bowman G.D., Deindl S. (2019) Remodeling the genome with DNA twists. Science, 366(6461):35-36. [Pubmed]
Bowman G.D. (2019) Uncovering a New Step in Sliding Nucleosomes. Trends Biochem Sci, 44(8):643-645. [Pubmed]
Levendosky R.F., Bowman G.D. (2019) Asymmetry between the two acidic patches dictates the direction of nucleosome sliding by the ISWI chromatin remodeler. eLife, 8. pii: e45472. [Pubmed]
Sabantsev A.*, Levendosky R.F.*, Zhuang X., Bowman G.D.#, Deindl S.# (2019) Direct observation of coordinated DNA movements on the nucleosome during chromatin remodelling. Nat Comm, 10(1):1720. *co-first; #co-corresponding [Pubmed]
[2018]Winger J., Nodelman I.M., Levendosky R.F., Bowman G.D. (2018) A twist defect mechanism for ATP-dependent translocation of nucleosomal DNA. eLife, 7:e34100 doi: 10.7554/eLife.34100 [Pubmed]
Tokuda J.M.*, Ren R.*, Levendosky R.F.*, Tay R.J., Yan M., Pollack L.#, Bowman G.D.# (2018) The ATPase motor of the Chd1 chromatin remodeler stimulates DNA unwrapping from the nucleosome. Nucleic Acids Res, 46(10):4978-4990. doi: 10.1093/nar/gky206. [Pubmed] *co-first authorship; #co-corresponding
[2017]Qiu Y., Levendosky R.F., Chakravarthy S., Patel A., Bowman G.D.*, Myong S*. (2017) The Chd1 chromatin remodeler shifts nucleosomal DNA bidirectionally as a monomer. Mol Cell, 68(1):76-88. *co-corresponding [Pubmed]
Wigley D.B.*, Bowman G.D.* (2017) A glimpse into chromatin remodeling. Nat Struct Mol Biol. 24(6):498-500. [Pubmed] *co-corresponding
Pilarowski G.O., Vernon H.J., Applegate C.D., Boukas L., Cho M.T., Gurnett C.A., Benke P.J., Beaver E., Heeley J.M., Medne L., Krantz I.D., Azage M., Niyazov D., Henderson L.B., Wentzensen I.M., Baskin B., Sacoto M.J.G., Bowman G.D., Bjornsson HT. (2017) Missense variants in the chromatin remodeler CHD1 are associated with neurodevelopmental disability. J Med Genet, pii: jmedgenet-2017-104759. [Pubmed]
Winger J., Bowman G.D. (2017) The Sequence of Nucleosomal DNA Modulates Sliding by the Chd1 Chromatin Remodeler. J Mol Biol, 429(6):808-822.[Pubmed]
Nodelman I.M., Bleichert F., Patel A., Ren R., Horvath K.C., Berger J.M., Bowman G.D. (2017) Interdomain communication of the Chd1 chromatin remodeler across the DNA gyres of the nucleosome. Mol Cell, 65(3):447-459. [Pubmed]
Bowman, G.D.* and McKnight, J.N.* (2017), Sequence-specific targeting of chromatin remodelers organizes precisely positioned nucleosomes throughout the genome. Bioessays, 39(1):1-8. [PubMed] *co-corresponding
[2016]Levendosky R.F., Sabantsev A., Deindl S., Bowman G.D. (2016) The Chd1 chromatin remodeler shifts hexasomes unidirectionally. eLife, 2016;10.7554/eLife.21356. [PubMed]
Nodelman I.M., Horvath K.C., Levendosky R.F., Winger J., Ren R., Patel A., Li M., Wang M.D., Roberts E., Bowman G.D. (2016) The Chd1 chromatin remodeler can sense both entry and exit sides of the nucleosome. Nucleic Acids Res, Sep 19;44(16):7580-91. [PubMed]
McKnight J.N.*, Tsukiyama T., Bowman G.D.* (2016) Sequence-targeted nucleosome sliding in vivo by a hybrid Chd1 chromatin remodeler. Genome Res, 26(5):693-704. [PubMed] *co-corresponding
Yan M., Chakravarthy S., Tokuda J.M., Pollack L., Bowman G.D.*, Lee Y.S.* (2016) Succinyl-5-aminoimidazole-4-carboxamide-1-ribose 5'-Phosphate (SAICAR) Activates Pyruvate Kinase Isoform M2 (PKM2) in Its Dimeric Form. Biochemistry, 55(33):4731-6. doi: 10.1021/acs.biochem.6b00658. [PubMed] *co-corresponding
Zucconi B.E., Luef B., Xu W., Henry R.A., Nodelman I.M., Bowman G.D., Andrews A.J., Cole P.A. (2016) Modulation of p300/CBP Acetylation of Nucleosomes by Bromodomain Ligand I-CBP112. Biochemistry, 55(27):3727-34. doi: 10.1021/acs.biochem.6b00480. [PubMed]
[2015]Bowman G.D.*, Poirier M.G.* (2015) Post-translational modifications of histones that influence nucleosome dynamics. Chem Rev, 115(6):2274-95. [PubMed] *co-corresponding
Hauk G., Bowman G.D. (2015) Formation of a Trimeric Xpo1-Ran[GTP]-Ded1 Exportin Complex Modulates ATPase and Helicase Activities of Ded1. PLoS One, 10(6):e0131690. [PubMed]
Li M., Hada A., Sen P., Olufemi L., Hall M.A., Smith B.Y., Forth S., McKnight J.N., Patel A., Bowman G.D., Bartholomew B., Wang M.D. (2015) Dynamic regulation of transcription factors by nucleosome remodeling. eLife, 2015 Jun 5;4. doi: 10.7554/eLife.06249 [PubMed]
Marold J.D., Kavran J.M., Bowman G.D., Barrick D. (2015) A Naturally Occurring Repeat Protein with High Internal Sequence Identity Defines a New Class of TPR-like Proteins. Structure, 23(11):2055-65. [PubMed]
[2013]Nodelman I.M., Bowman G.D. (2013) Nucleosome sliding by Chd1 does not require rigid coupling between DNA-binding and ATPase domains. EMBO Reports, 14(12):1098-103. [PubMed]
Torigoe S.E., Patel A., Khuong M.T., Bowman G.D., Kadonaga J.T. (2013) ATP-dependent Chromatin Assembly Is Functionally Distinct from Chromatin Remodeling. eLife 2013;2:e00863. [PubMed]
Patel A., Chakravarthy S., Morrone S., Nodelman I.M., McKnight J.N., Bowman G.D. (2013) Decoupling nucleosome recognition from DNA binding dramatically alters the properties of the Chd1 chromatin remodeler. Nucleic Acid Res, 41(3):1637-48. [PubMed]
[2012]Chakravarthy, S., Patel, A., Bowman, G.D. (2012) The basic linker of macroH2A stabilizes DNA at the entry/exit site of the nucleosome. Nucleic Acid Res, 40(17):8285-95. [PubMed]
Ye Y., Stahley M., Xu J., Friedman J., Sun Y., McKnight J., Gray J., Bowman G.D., Stivers, J. (2012) Enzymatic excision of uracil residues in nucleosomes depends on local DNA structure and dynamics. Biochemistry, 51: 6028–6038. [PubMed]
[2011]Sharma A., Jenkins K.R., Héroux A., Bowman G.D. (2011) Crystal Structure of the Chromodomain Helicase DNA-Binding Protein 1 (Chd1) DNA-Binding Domain in Complex with DNA. J Biol Chem, 286 (49):42099-104. [PubMed]
Patel A., McKnight J., Genzor P., Bowman G.D. (2011) Identification of Residues in Chromodomain Helicase DNA-Binding Protein 1 (Chd1) Required for Coupling ATP Hydrolysis to Nucleosome Sliding. J Biol Chem, 286 (51):43984-93. [PubMed]
Hauk G. & Bowman G.D. (2011) Structural Insights into Regulation and Action of SWI2/SNF2 ATPases. Curr Opin Struct Biol, 21(6):719-27 [PubMed]
McKnight J., Jenkins K., Nodelman I.M., Escobar T., Bowman G.D. (2011) Extranucleosomal DNA Binding Directs Nucleosome Sliding By Chd1. Mol Cell Biol, 31(23):4746-59. [PubMed]
[2010]Hauk G.*, McKnight J.*, Nodelman I.M., Bowman G.D. (2010) The Chromodomains of the Chd1 Chromatin Remodeler Regulate DNA Access to the ATPase Motor. Mol Cell, 39(5):711-23. *co-first authorship [PubMed]
Bowman G.D. (2010) Mechanisms of ATP-dependent nucleosome sliding. Curr Opin Struct Biol, 20(1): 73-81. [PubMed]
Sczepanski J.T., Wong R.S., McKnight J.N., Bowman G.D., Greenberg M.M. (2010) Rapid DNA-protein cross-linking and strand scission by an abasic site in a nucleosome core particle. Proc Natl Acad Sci U S A, 107(52):22475-80. [PubMed]
[2009]Celedon A., Nodelman I.M., Wildt B., Dewan R., Searson P., Wirtz D., Bowman G.D., Sun S.X. (2009) Magnetic tweezers measurement of single molecule torque. Nano Lett, 9(4):1720-1725. [PubMed]