.
Weekly Seminar

Home
Weekly Seminar

Annual Symposium

CEAFM Dual Degree Program
Members

Contact

Weekly Seminar: Fall 2018

Speaker: Prof. Soojung Claire Hur (Johns Hopkins University)
Title:
"Differential Inertial Microfluidics for Biomedical Research"
Hosted By: Rajat Mittal (ME)

Date: Friday, September 14, 2018
Time: 3:00 p.m.
Location: Gilman Hall 132


Abstract

Rapid advances in clinical medicine have revealed formidable obstacles associated with individual variations in treatment responses. The heterogeneity leads to the development of personalized medicine for better therapeutic outcomes, but systematic and quantitative single-cell level analyses are imperative to identify factors contributing to the heterogeneity. My research group develops microfluidic systems that observe and modulate single cell behaviors to yield new insights into these clinical questions.

Particularly, we are interested in the understanding relationship between physical properties and cellular phenotypes because not only biophysical properties impact cellular functions but also cellular functions can be regulated and manipulated by physical environmental cues. Differential inertial microfluidic devices are great candidates to study these relationships since one can (i) precisely and distinctively positions cells in flow based on their intrinsic physical properties, and (ii) isolate and maintain identical populations of cells in the designated regions in the channel during the courses of cellular function modulating steps. Using softness-dependent distinctive cellular positions inflow, we adapted the system to conduct passive, label-free and continuous cell enrichment based on their physical properties. Moreover, we developed a simple molecular probe delivery system with improved single-cell transfection capability using vortex-generating inertial microfluidics’ ability to contain cells in pre-determined locations and to release on-demand. Collectively, my research group endeavors to develop innovative techniques that have the potential for high-throughput target cell detection, cost-effective cell separation, and sequential multimolecular delivery, useful for oncology, immunology, gene therapy and regenerative medicine.

Bio

Soojung Claire Hur is the Clare Boothe Luce Assistant Professor in the Department of Mechanical Engineering at Johns Hopkins University. She received her B.S., M.S. and Ph.D. in Mechanical Engineering from UCLA in 2005, 2007 and 2011, respectively. After her doctoral training, she joined the Rowland Institute at Harvard University as one of two Rowland Fellows in September 2011 with five years of research funding. Before joining the Johns Hopkins University, she managed the clinical studies funded by the Vortex Biosciences, Inc. as an assistant researcher at UCLA Department of Bioengineering. She has won numerous awards and scholarships, including Edward K. Rice Outstanding Doctoral Student award, HSSEAS academic scholarship, MAE department's Chevron scholarship and UCLA Dean's special fellowship, the 2018 inaugural Johnson and Johnson WiSTEM2D scholar award and the School of Engineering Faculty Award at the 2018 Johns Hopkins Department of Medicine Research Retreat. She co-authored 14 peer-reviewed journals, including three articles featured as journal covers, 40+ conference proceedings, 3 US patents, and two international patents.



Upcoming Seminar

Speaker: Dr. Michael Wilczek (Max Planck Research Group)
Title: "Turbulence and Pattern Formation in a Minimal Model for Active Fluids"

Date: Friday, November 16, 2018
Time: 3:00 p.m.
Location: Gilman Hall 132

» More information »