? Gilkes Lab

Welcome to the Gilkes Lab

Breast and Ovarian Cancer Program | Johns Hopkins School of Medicine

About

Gilkes Lab


Our lab is part of the Breast and Ovarian Cancer Program at the Johns Hopkins School of Medicine. Of the deaths attributed to cancer, 90% are due to metastasis, and treatments that prevent or cure metastasis remain elusive. Emerging data indicate that low oxygen tension (hypoxia), which occurs in most solid tumors, alters the biophysical and biochemical parameters of the extracellular matrix within a tumor. Our work is focused on the role of hypoxia in breast cancer. One of our main interests are some particular genetic alterations that happen under hypoxia. We are also investigating how hypoxia promotes ECM organization and metastasis. We are a dynamic and creative lab that always likes a good challenge. We address our questions through 2D and 3D in vitro, and in vivo systems. Our goal is to fully comprehend the impact that hypoxia can have in breast cancer patient outcome.

We are currently looking for a post-doctoral fellow. Please email Daniele at dgilkes1@jhu.edu with a CV for further inquiry!

News

Click here to see the most recent updates, news, and events from our lab!

Research

People

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Daniele Gilkes, PhD

Principal Investigator

Daniele M. Gilkes is an Assistant Professor in the Oncology Department, under the Breast and Ovarian Cancer Program, at Johns Hopkins School of Medicine. She earned B.S.ChE and M.S. degrees in the University of Florida. After completing her PhD in Cancer Biology at the University of South Florida, Daniele became a Susan G. Komen Postdoctoral Fellow in the lab of Gregg Semenza, MD, PhD at Johns Hopkins School of Medicine. Later, she became a Research Assistant Professor in the lab of Denis Wirtz, PhD in the Chemical & Biomolecular Engineering Department at Johns Hopkins University. Daniele opened her lab in 2015, and now focuses on studying the role of the tumor microenvironment, primarily hypoxia and the extracellular matrix, in breast cancer.

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Inês Godet

PhD Student

Inês Godet is a PhD candidate in the Chemical & Biomolecular Engineering Department at Johns Hopkins University. She earned B.S.BioChem and M.S. degrees at Técnico Lisboa - Lisbon University. In 2015, she conducted research for her Master's thesis in the lab of Denis Wirtz, PhD, where she developed a high throughput 3D in vitro system for invasion and chemoresistance studies. Currently, she studies the role of hypoxia in breast cancer metastasis through the use of a novel hypoxia fate-mapping system.

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Josh DiGiacomo

PhD Student

Josh DiGiacomo is a PhD candidate of the Chemical & Biomolecular Engineering Department at Johns Hopkins University. He received a B.S. in Chemical & Biomolecular Engineering and Molecular & Cellular Biology from Johns Hopkins University in 2016. He previously researched the spatio-temporal invasion of fibrosarcoma and breast cancer in 3D collagen matrices in the lab of Denis Wirtz, PhD. Currently, he studies the effects of extracellular matrix signaling on breast cancer phenotypes and gene expression.

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Shyanne Salen

Master's Student

Shyanne is a Master's student who graduated from Bucknell University in 2018 with a B.S. in Chemical Engineering. She is now in the Department of Chemical & Biomolecular Engineering at Johns Hopkins University. She is now working to help uncover the impacts of hypoxia in breast cancer. She eventually wants to obtain a PhD.

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Mahelet Mamo

Post-Baccalaureate Researcher

Mahelet is a post-baccaleureate researcher who graduated from Longwood University in 2018 with a B.S. in Biology. She came to us through the Doctoral Diversity Program at Johns Hopkins School of Medicine. She is currently working on identifying and characterizing novel hypoxia-regulated genes. She aims to complete an MD-PhD in the future.

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Undergraduate Research Assistant

Undergraduate student majoring in Molecular & Cellular Biology at Johns Hopkins University

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Undergraduate Research Assistant

Undergraduate student majoring in Chemical & Biomolecular Engineering at Johns Hopkins University

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Undergraduate Research Assistant

Undergraduate student majoring in Chemical & Biomolecular Engineering at Johns Hopkins University

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Undergraduate Research Assistant

Undergraduate student majoring in Chemical & Biomolecular Engineering at Johns Hopkins University

Click here to see a list of our former members and what they're up to now!

Publications

Feel free to contact us


General Inquiry: gilkeslab@gmail.com

Direct Correspondence: dgilkes1@jhu.edu

Breast & Ovarian Cancer Program

1650 Orleans Street

CRBI Room 128

Baltimore MD, 21231

Funding

If you are interested in supporting our lab's research, gifts are accepted here.