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The newspaper of The Johns Hopkins University July 24, 2006 | Vol. 35 No. 40
'Sacred mushrooms' induce mystical experience

Rigorous study conducted at Johns Hopkins is hailed as a landmark

By Marjorie Centofanti
Johns Hopkins Medicine

Using unusually rigorous scientific conditions and measures, Johns Hopkins researchers have shown that the active agent in "sacred mushrooms" can induce mystical/spiritual experiences descriptively identical to spontaneous ones people have reported for centuries.

The resulting experiences apparently prompt positive changes in behavior and attitude that last several months at least.

The agent, a plant alkaloid called psilocybin, mimics the effect of serotonin on brain receptors, as do some other hallucinogens, but precisely where in the brain and in what manner are unknown.

An account of the study, accompanied by an editorial and four experts' commentaries, appeared online July 11 in the journal Psychopharmacology.

Cited as "landmark" in the commentary by Charles Schuster, former director of the National Institute on Drug Abuse, the research marks a new systematic approach to studying certain hallucinogenic compounds that, in the 1950s, showed signs of therapeutic potential or value in research into the nature of consciousness and sensory perception. "Human consciousness is a function of the ebb and flow of neural impulses in various regions of the brain, the very substrate that drugs such as psilocybin act upon," Schuster said. "Understanding what mediates these effects is clearly within the realm of neuroscience and deserves investigation."

Study leader Roland Griffiths, a professor in the departments of Neuroscience and Psychiatry and Behavioral Biology in the Johns Hopkins School of Medicine, said, "A vast gap exists between what we know of these drugs-mostly from descriptive anthropology-and what we believe we can understand using modern clinical pharmacology techniques. That gap is large because, as a reaction to the excesses of the 1960s, human research with hallucinogens has been basically frozen in time these last 40 years."

All of the study's authors caution about substantial risks of taking psilocybin under conditions not appropriately supervised. "Even in this study, where we greatly controlled conditions to minimize adverse effects, about a third of subjects reported significant fear, with some also reporting transient feelings of paranoia," Griffiths said. "Under unmonitored conditions, it's not hard to imagine those emotions escalating to panic and dangerous behavior."

The researchers' message isn't just that psilocybin can produce mystical experiences. "I had a healthy skepticism going into this," Griffiths said, "and that finding alone was a surprise." But, as important, he said, "is that, under very defined conditions, with careful preparation, you can safely and fairly reliably occasion what's called a primary mystical experience that may lead to positive changes in a person. It's an early step in what we hope will be a large body of scientific work that will ultimately help people."

The authors acknowledge the unusual nature of the work, treading, as it does, a fine line between neuroscience and areas most would consider outside the realm of science. "But establishing the basic science here is necessary," Griffiths said, "to take advantage of the possible benefits psilocybin can bring to our understanding of how thought, emotion and, ultimately, behavior are grounded in biology."

Griffiths is quick to emphasize the scientific intent of the study. "We're just measuring what can be observed," he said. "We're not entering into 'Does God exist or not exist?' This work can't and won't go there."

In the study, more than 60 percent of subjects described the effects of psilocybin in ways that met criteria for a "full mystical experience" as measured by established psychological scales. One-third said that the experience was the single most spiritually significant of their lifetimes, and more than two-thirds rated it among their five most meaningful and spiritually significant. Griffiths said that subjects likened it to the importance of the birth of their first child or the death of a parent.

Two months later, 79 percent of subjects reported moderately or greatly increased well-being or life satisfaction, compared with those given a placebo at the same test session. A majority said their mood, attitudes and behaviors had changed for the better. Structured interviews with family members, friends and co-workers generally confirmed the subjects' remarks. Results of a yearlong follow-up are being readied for publication.

Psychological tests and subjects' own reports showed no harm to study participants, though some admitted extreme anxiety or other unpleasant effects in the hours following the psilocybin capsule. The drug has not been observed to be addictive or physically toxic in animal studies or human populations. "In this regard," said Griffiths, a psychopharmacologist, "it contrasts with MDMA [ecstasy], amphetamines or alcohol."

The study isn't the first with psilocybin, the researchers say, though some of the earlier ones, done elsewhere, had notably less rigorous design, were less thorough in measuring outcomes or lacked longer-term follow-up.

In the present work, 36 healthy, well-educated volunteers — most of them middle-aged with no family history of psychosis or bipolar disorder — were selected. All had active spiritual practices. "We thought a familiarity with spiritual practice would give them a framework for interpreting their experiences and that they'd be less likely to be confused or troubled by them," Griffiths said. All gave informed consent to the study approved by Johns Hopkins' institutional review board.

Thirty of the subjects each attended two separate eight-hour drug sessions, conducted at two-month intervals. In one, they received psilocybin; in another, methylphenidate (Ritalin), the active placebo.

In designing the study, researchers had to overcome or, at least, greatly minimize two hurdles: the risk of adverse side effects and the likelihood that the expectations of getting the test drug or the placebo would influence subjects' perceptions.

To lessen the former, each subject met several times before drug sessions began with a reassuring "monitor," a medical professional experienced in observing drug-study participants. Monitors stayed with the participants during the capsule-taking sessions. Actual trials took place in a room outfitted like a comfortable, slightly upscale living room, with soft music and indirect nonlaboratory lighting. Heart rate and blood pressure were measured throughout.

The researchers countered "expectancy" by having both monitors and subjects "blinded" to what substance would be given. For ethical reasons, subjects were told about hallucinogens' possible effects, and they also learned that they might get other substances — weak or strong — that could change perception or consciousness. Most important, a third "red herring" group of six subjects had two blinded placebo sessions, then were told they'd receive psilocybin at a third. This tactic-later verified by questionnaires-kept participants and monitors in the dark at the first two sessions about each capsule's contents.

Nine established questionnaires and a new specially created follow-up survey were used to rate experiences at appropriate times in the study. They included those that differentiate effects of psychoactive drugs, detect altered states of consciousness, rate mystical experiences and assess changes in outlook.

The study, Griffiths said, has advanced the understanding of hallucinogen abuse.

As for where the work could lead, the team is planning a trial of patients suffering from advanced cancer-related depression or anxiety, following up suggestive research conducted several decades ago. They're also designing studies to test a role for psilocybin in treating drug dependence.

The study was funded by grants from NIDA and the Council on Spiritual Practices.

Una McCann and William Richards, both of Johns Hopkins, and Robert Jesse, of the Council on Spiritual Practices in San Francisco, were co-researchers.

The commentaries on this study that appear in this issue of Psychopharmacology are available online here and include remarks by Solomon Snyder, Distinguished Service Professor of Neuroscience, Pharmacology and Psychiatry at Johns Hopkins; former NIDA head Schuster, now Distinguished Professor of Psychiatry and Behavioral Neuroscience at the Wayne State University School of Medicine; Herbert Kleber, professor of psychiatry at Columbia University and a former deputy director of the White House Office of National Drug Control Policy; David Nichols, with the Purdue University School of Pharmacy and Pharmaceutical Sciences; and Psychopharmacology editor Harriet de Wit, of the University of Chicago Department of Psychiatry.


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