Researchers Recognized for Contributions to
Understanding Vision
King-Wai Yau and Jeremy
Nathans
Photo by Jay Corey
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By Audrey Huang Johns Hopkins Medicine
Jeremy Nathans, professor of molecular biology and
genetics and
ophthalmology, and King-Wai
Yau, professor of
neuroscience and ophthalmology, have been awarded the
2008 Antonio
Champalimaud Vision Award by the Champalimaud Foundation in
Portugal for their "ground-breaking
discoveries in the laboratory that enhance our knowledge
and understanding of vision."
Nathans and Yau will share the $1.45 million award,
which was presented on Sept. 9 at a
ceremony in Lisbon.
Nathans has identified the genes that code for the
three kinds of light-sensing pigment
molecules found in the cone cells, one of the two types of
photoreceptor cells in the retina, the other
being rods. The pigments are critical for color vision, and
Nathans has shown that alterations in these
pigment genes are responsible for color blindness —
common inherited variations in human color vision.
In more recent studies, Nathans discovered and
characterized genes that control the normal
development of the retina and determined how defects in
these genes disrupt the function and
survival of retinal cells. These studies have revealed
several defects that lead to human retinal
diseases including Stargardt disease, the most common type
of macular degeneration in children and
young adults. Working together, Nathans and Yau also
determined the cause of the vitelliform type of
macular dystrophy, showing that it is caused by
abnormalities in a member of a previously unknown
family of ion channels — proteins that allow ions to
enter and exit cells.
Yau has over the years uncovered the critical roles
played by two key signaling molecules —
calcium and cyclic GMP — in the process of converting
light into electrical signals by the rod and cone
photoreceptor cells in the retina, a process known as
visual transduction. He has established that
cyclic GMP controls the electrical signal by controlling
ion channels, and that calcium controls the
adaptation to light. Yau's discoveries have led to major
advances in the understanding of many
hereditary blinding diseases that affect rod and cone
cells. More recently, Yau characterized the
light-response behaviors of a newly discovered type of
photoreceptor cell in the retina. This
subpopulation of pigment-containing retinal ganglion cells
can react to light and affect circadian
rhythms and other nonimage aspects of vision. This body of
work helps explain why some blind people
who have lost function of their rods and cones and are
unable to see can still sense light and are
somehow synchronized to day-night cycles. Yau also is a
leader in the field of olfactory transduction,
which mechanistically bears similarities to visual
transduction.
The Champalimaud Foundation is a private organization
based in Portugal and dedicated to
supporting the development of research in the medical
sciences. Its focus is the diagnosis, treatment
and prevention of global illness and disease. Its Vision
Award is the largest monetary prize in the field
of vision and one of the largest scientific prizes in the
world.
Related Web sites
Jeremy Nathans
King-Wai Yau
The Champalimaud Foundation
GO TO SEPTEMBER 15,
2008
TABLE OF CONTENTS.
GO TO THE GAZETTE
FRONT PAGE.
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