Publications
  1. Schuller AP, Green R. (2017) The ABC(E1)s of Ribosome Recycling and Reinitiation. Mol Cell 66: 578-580
    PubMed Link | Link to Article
  2. McClary B, Zinshteyn B, Meyer M, Jouanneau M, Pellegrino S, Yusupova G, Schuller A, Reyes JCP, Lu J, Guo Z, Ayinde S, Luo C, Dang Y, Romo D, Yusupov M, Green R, Liu JO. (2017) Inhibition of Eukaryotic Translation by the Antitumor Natural Product Agelastatin A. Cell Chem Biol 24: 605-613.e5
    PubMed Link | Link to Article
  3. Schuller AP, Wu CC, Dever TE, Buskirk AR, Green R. (2017) eIF5A Functions Globally in Translation Elongation and Termination. Mol Cell 66: 194-205.e5
    PubMed Link | Link to Article
  4. Mills EW, Green R, Ingolia NT. (2017) Slowed decay of mRNAs enhances platelet specific translation. Blood 129: e38-e48
    PubMed Link | Link to Article
  5. Guydosh NR, Green R. (2017) Translation of poly(A) tails leads to precise mRNA cleavage. RNA 23: 749-761
    PubMed Link | Link to Article
  6. Buskirk AR, Green R. (2017) Ribosome pausing, arrest and rescue in bacteria and eukaryotes. Philos Trans R Soc Lond B Biol Sci
    PubMed Link | Link to Article
  7. Arthur LL, Chung JJ, Jankirama P, Keefer KM, Kolotilin I, Pavlovic-Djuranovic S, Chalker DL, Grbic V, Green R, Menassa R, True HL, Skeath JB, Djuranovic S. (2017) Rapid generation of hypomorphic mutations. Nat Commun 8: 14112
    PubMed Link | Link to Article
  8. Zinshteyn B, Green R. (2016) When stop makes sense. Science 354: 1106
    PubMed Link | Link to Article
  9. Mills EW, Wangen J, Green R, Ingolia NT. (2016) Dynamic Regulation of a Ribosome Rescue Pathway in Erythroid Cells and Platelets. Cell Rep 17: 1-10
    PubMed Link | Link to Article
  10. Radhakrishnan A, Chen YH, Martin S, Alhusaini N, Green R, Coller J. (2016) The DEAD-Box Protein Dhh1p Couples mRNA Decay and Translation by Monitoring Codon Optimality. Cell 167: 122-132.e9
    PubMed Link | Link to Article
  11. Radhakrishnan A, Green R. (2016) Connections Underlying Translation and mRNA Stability. J Mol Biol 428: 3558-64
    PubMed Link | Link to Article
  12. Mohammad F, Woolstenhulme CJ, Green R, Buskirk AR. (2016) Clarifying the Translational Pausing Landscape in Bacteria by Ribosome Profiling. Cell Rep 14: 686-94
    PubMed Link | Link to Article
  13. Koutmou KS, Radhakrishnan A, Green R. (2015) Synthesis at the Speed of Codons. Trends Biochem Sci 40: 717-8
    PubMed Link | Link to Article
  14. Arthur L, Pavlovic-Djuranovic S, Smith-Koutmou K, Green R, Szczesny P, Djuranovic S. (2015) Translational control by lysine-encoding A-rich sequences. Sci Adv
    PubMed Link | Link to Article
  15. Young DJ, Guydosh NR, Zhang F, Hinnebusch AG, Green R. (2015) Rli1/ABCE1 Recycles Terminating Ribosomes and Controls Translation Reinitiation in 3'UTRs In Vivo. Cell 162: 872-84
    PubMed Link | Link to Article
  16. Kowalinski E, Schuller A, Green R, Conti E. (2015) Saccharomyces cerevisiae Ski7 Is a GTP-Binding Protein Adopting the Characteristic Conformation of Active Translational GTPases. Structure 23: 1336-43
    PubMed Link | Link to Article
  17. Woolstenhulme CJ, Guydosh NR, Green R, Buskirk AR. (2015) High-precision analysis of translational pausing by ribosome profiling in bacteria lacking EFP. Cell Rep 82: 54-6
    PubMed Link | Link to Article
  18. Koutmou KS, Schuller AP, Brunelle JL, Radhakrishnan A, Djuranovic S, Green R. (2015) Ribosomes slide on lysine-encoding homopolymeric A stretches. Elife
    PubMed Link | Link to Article
  19. Preis A, Heuer A, Barrio-Garcia C, Hauser A, Eyler DE, Berninghausen O, Green R, Becker T, Beckmann R. (2014) Cryoelectron microscopic structures of eukaryotic translation termination complexes containing eRF1-eRF3 or eRF1-ABCE1. Cell Rep 8: 59-65
    PubMed Link | Link to Article
  20. Petropoulos AD, McDonald ME, Green R, Zaher HS. (2014) Distinct roles for release factor 1 and release factor 2 in translational quality control. J Biol Chem 289: 17589-96
    PubMed Link | Link to Article
  21. Koutmou KS, McDonald ME, Brunelle JL, Green R. (2014) RF3:GTP promotes rapid dissociation of the class 1 termination factor. RNA 20: 609-20
    PubMed Link | Link to Article
  22. Guydosh NR, Green R. (2014) Dom34 rescues ribosomes in 3' untranslated regions. Cell 156: 950-62
    PubMed Link | Link to Article
  23. van den Elzen AM, Schuller A, Green R, Séraphin B. (2014) Dom34-Hbs1 mediated dissociation of inactive 80S ribosomes promotes restart of translation after stress. EMBO J 33: 265-76
    PubMed Link | Link to Article
  24. Eyler DE, Wehner KA, Green R. (2013) Eukaryotic release factor 3 is required for multiple turnovers of peptide release catalysis by eukaryotic release factor 1. J Biol Chem 288: 29530-8
    PubMed Link | Link to Article
  25. Hur JK, Zinchenko MK, Djuranovic S, Green R. (2013) Regulation of Argonaute slicer activity by guide RNA 3' end interactions with the N-terminal lobe. J Biol Chem 288: 7829-40
    PubMed Link | Link to Article
  26. Buskirk AR, Green R. (2013) Biochemistry. Getting past polyproline pauses. Science 339: 38-9
    PubMed Link | Link to Article
  27. Shaw JJ, Trobro S, He SL, Åqvist J, Green R. (2012) A Role for the 2' OH of peptidyl-tRNA substrate in peptide release on the ribosome revealed through RF-mediated rescue. Chem Biol 19: 983-93
    PubMed Link | Link to Article
  28. Provost E, Wehner KA, Zhong X, Ashar F, Nguyen E, Green R, Parsons MJ, Leach SD. (2012) Ribosomal biogenesis genes play an essential and p53-independent role in zebrafish pancreas development. Development 139: 3232-41
    PubMed Link | Link to Article
  29. Dever TE, Green R. (2012) The elongation, termination, and recycling phases of translation in eukaryotes. Cold Spring Harb Perspect Biol 4: a013706
    PubMed Link | Link to Article
  30. Shoemaker CJ, Green R. (2012) Translation drives mRNA quality control. Nat Struct Mol Biol 19: 594-601
    PubMed Link | Link to Article
  31. Djuranovic S, Nahvi A, Green R. (2012) miRNA-mediated gene silencing by translational repression followed by mRNA deadenylation and decay. Science 336: 237-40
    PubMed Link | Link to Article
  32. Agirrezabala X, Liao HY, Schreiner E, Fu J, Ortiz-Meoz RF, Schulten K, Green R, Frank J. (2012) Structural characterization of mRNA-tRNA translocation intermediates. Proc Natl Acad Sci U S A 109: 6094-9
    PubMed Link | Link to Article
  33. Petropoulos AD, Green R. (2012) Further in vitro exploration fails to support the allosteric three-site model. J Biol Chem 287: 11642-8
    PubMed Link | Link to Article
  34. Becker T, Franckenberg S, Wickles S, Shoemaker CJ, Anger AM, Armache JP, Sieber H, Ungewickell C, Berninghausen O, Daberkow I, Karcher A, Thomm M, Hopfner KP, Green R, Beckmann R. (2012) Structural basis of highly conserved ribosome recycling in eukaryotes and archaea. Nature 482: 501-6
    PubMed Link | Link to Article
  35. McDonald ME, Green R. (2012) Another burst of smoke: atomic resolution structures of RF3 bound to the ribosome. RNA 18: 605-9
    PubMed Link | Link to Article
  36. Shoemaker CJ, Green R. (2011) Kinetic analysis reveals the ordered coupling of translation termination and ribosome recycling in yeast. Proc Natl Acad Sci U S A 108: E1392-8
    PubMed Link | Link to Article
  37. Zaher HS, Green R. (2011) A primary role for release factor 3 in quality control during translation elongation in Escherichia coli. Cell 147: 396-408
    PubMed Link | Link to Article
  38. Miller MR, Liu Z, Cazier DJ, Gebhard GM, Herron SR, Zaher HS, Green R, Buskirk AR. (2011) The role of SmpB and the ribosomal decoding center in licensing tmRNA entry into stalled ribosomes. RNA 17: 1727-36
    PubMed Link | Link to Article
  39. Dang Y, Schneider-Poetsch T, Eyler DE, Jewett JC, Bhat S, Rawal VH, Green R, Liu JO. (2011) Inhibition of eukaryotic translation elongation by the antitumor natural product Mycalamide B. RNA 17: 1578-88
    PubMed Link | Link to Article
  40. Ortiz-Meoz RF, Green R. (2011) Helix 69 is key for uniformity during substrate selection on the ribosome. J Biol Chem 286: 25604-10
    PubMed Link | Link to Article
  41. Zaher HS, Shaw JJ, Strobel SA, Green R. (2011) The 2'-OH group of the peptidyl-tRNA stabilizes an active conformation of the ribosomal PTC. EMBO J 30: 2445-53
    PubMed Link | Link to Article
  42. Eyler DE, Green R. (2011) Distinct response of yeast ribosomes to a miscoding event during translation. RNA 17: 925-32
    PubMed Link | Link to Article
  43. Agirrezabala X, Schreiner E, Trabuco LG, Lei J, Ortiz-Meoz RF, Schulten K, Green R, Frank J. (2011) Structural insights into cognate versus near-cognate discrimination during decoding. EMBO J 30: 1497-507
    PubMed Link | Link to Article
  44. Djuranovic S, Nahvi A, Green R. (2011) A parsimonious model for gene regulation by miRNAs. Science 331: 550-3
    PubMed Link | Link to Article
  45. Shoemaker CJ, Eyler DE, Green R. (2010) Dom34:Hbs1 promotes subunit dissociation and peptidyl-tRNA drop-off to initiate no-go decay. Science 330: 369-72
    PubMed Link | Link to Article
  46. Ortiz-Meoz RF, Green R. (2010) Functional elucidation of a key contact between tRNA and the large ribosomal subunit rRNA during decoding. RNA 16: 2002-13
    PubMed Link | Link to Article
  47. Zaher HS, Green R. (2010) Kinetic basis for global loss of fidelity arising from mismatches in the P-site codon:anticodon helix. RNA 16: 1980-9
    PubMed Link | Link to Article
  48. Zaher HS, Green R. (2010) Hyperaccurate and error-prone ribosomes exploit distinct mechanisms during tRNA selection. Mol Cell 39: 110-20
    PubMed Link | Link to Article
  49. He SL, Green R. (2010) Visualization of codon-dependent conformational rearrangements during translation termination. Nat Struct Mol Biol 17: 465-70
    PubMed Link | Link to Article
  50. Schneider-Poetsch T, Ju J, Eyler DE, Dang Y, Bhat S, Merrick WC, Green R, Shen B, Liu JO. (2010) Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin. Nat Chem Biol 6: 209-217
    PubMed Link | Link to Article
  51. Djuranovic S, Zinchenko MK, Hur JK, Nahvi A, Brunelle JL, Rogers EJ, Green R. (2010) Allosteric regulation of Argonaute proteins by miRNAs. Nat Struct Mol Biol 17: 144-50
    PubMed Link | Link to Article
  52. Saini P, Eyler DE, Green R, Dever TE. (2009) Hypusine-containing protein eIF5A promotes translation elongation. Nature 459: 118-21
    PubMed Link | Link to Article
  53. Nahvi A, Shoemaker CJ, Green R. (2009) An expanded seed sequence definition accounts for full regulation of the hid 3' UTR by bantam miRNA. RNA 15: 814-22
    PubMed Link | Link to Article
  54. Zaher HS, Green R. (2009) Fidelity at the molecular level: lessons from protein synthesis. Cell 136: 746-62
    PubMed Link | Link to Article
  55. Zaher HS, Green R. (2009) Quality control by the ribosome following peptide bond formation. Nature 457: 161-6
    PubMed Link | Link to Article
  56. Li W, Agirrezabala X, Lei J, Bouakaz L, Brunelle JL, Ortiz-Meoz RF, Green R, Sanyal S, Ehrenberg M, Frank J. (2008) Recognition of aminoacyl-tRNA: a common molecular mechanism revealed by cryo-EM. EMBO J 27: 3322-31
    PubMed Link | Link to Article
  57. Agirrezabala X, Lei J, Brunelle JL, Ortiz-Meoz RF, Green R, Frank J. (2008) Visualization of the hybrid state of tRNA binding promoted by spontaneous ratcheting of the ribosome. Mol Cell 32: 190-7
    PubMed Link | Link to Article
  58. Brunelle JL, Shaw JJ, Youngman EM, Green R. (2008) Peptide release on the ribosome depends critically on the 2' OH of the peptidyl-tRNA substrate. RNA 14: 1526-31
    PubMed Link | Link to Article
  59. Youngman EM, McDonald ME, Green R. (2008) Peptide release on the ribosome: mechanism and implications for translational control. Annu Rev Microbiol 62: 353-73
    PubMed Link | Link to Article
  60. Youngman EM, He SL, Nikstad LJ, Green R. (2007) Stop codon recognition by release factors induces structural rearrangement of the ribosomal decoding center that is productive for peptide release. Mol Cell 28: 533-43
    PubMed Link | Link to Article
  61. Shaw JJ, Green R. (2007) Two distinct components of release factor function uncovered by nucleophile partitioning analysis. Mol Cell 28: 458-67
    PubMed Link | Link to Article
  62. Sharma D, Cukras AR, Rogers EJ, Southworth DR, Green R. (2007) Mutational analysis of S12 protein and implications for the accuracy of decoding by the ribosome. J Mol Biol 374: 1065-76
    PubMed Link | Link to Article
  63. Youngman EM, Green R. (2007) Ribosomal translocation: LepA does it backwards. Curr Biol 17: R136-9
    PubMed Link | Link to Article
  64. Green R, Doudna JA. (2006) RNAs regulate biology. ACS Chem Biol 1: 335-8
    PubMed Link | Link to Article
  65. Cochella L, Brunelle JL, Green R. (2007) Mutational analysis reveals two independent molecular requirements during transfer RNA selection on the ribosome. Nat Struct Mol Biol 14: 30-6
    PubMed Link | Link to Article
  66. Dorner S, Lum L, Kim M, Paro R, Beachy PA, Green R. (2006) A genomewide screen for components of the RNAi pathway in Drosophila cultured cells. Proc Natl Acad Sci U S A 103: 11880-5
    PubMed Link | Link to Article
  67. Dorner S, Brunelle JL, Sharma D, Green R. (2006) The hybrid state of tRNA binding is an authentic translation elongation intermediate. Nat Struct Mol Biol 13: 234-41
    PubMed Link | Link to Article
  68. Brunelle JL, Youngman EM, Sharma D, Green R. (2006) The interaction between C75 of tRNA and the A loop of the ribosome stimulates peptidyl transferase activity. RNA 12: 33-9
    PubMed Link | Link to Article
  69. Youngman EM, Green R. (2005) Affinity purification of in vivo-assembled ribosomes for in vitro biochemical analysis. Methods 36: 305-12
    PubMed Link | Link to Article
  70. Cochella L, Green R. (2005) Fidelity in protein synthesis. Curr Biol 15: R536-40
    PubMed Link | Link to Article
  71. Cochella L, Green R. (2005) An active role for tRNA in decoding beyond codon:anticodon pairing. Science 308: 1178-80
    PubMed Link | Link to Article
  72. Cukras AR, Green R. (2005) Multiple effects of S13 in modulating the strength of intersubunit interactions in the ribosome during translation. J Mol Biol 349: 47-59
    PubMed Link | Link to Article
  73. Cochella L, Green R. (2004) Wobble during decoding: more than third-position promiscuity. Nat Struct Mol Biol 11: 1160-2
    PubMed Link | Link to Article
  74. Semrad K, Green R, Schroeder R. (2004) RNA chaperone activity of large ribosomal subunit proteins from Escherichia coli. RNA 10: 1855-60
    PubMed Link | Link to Article
  75. Weinger JS, Parnell KM, Dorner S, Green R, Strobel SA. (2004) Substrate-assisted catalysis of peptide bond formation by the ribosome. Nat Struct Mol Biol 11: 1101-6
    PubMed Link | Link to Article
  76. Youngman EM, Brunelle JL, Kochaniak AB, Green R. (2004) The active site of the ribosome is composed of two layers of conserved nucleotides with distinct roles in peptide bond formation and peptide release. Cell 117: 589-99
    PubMed Link
  77. Merryman C, Green R. (2004) Transformation of aminoacyl tRNAs for the in vitro selection of "drug-like" molecules. Chem Biol 11: 575-82
    PubMed Link | Link to Article
  78. Cochella L, Green R. (2004) Isolation of antibiotic resistance mutations in the rRNA by using an in vitro selection system. Proc Natl Acad Sci U S A 101: 3786-91
    PubMed Link | Link to Article
  79. Sharma D, Southworth DR, Green R. (2004) EF-G-independent reactivity of a pre-translocation-state ribosome complex with the aminoacyl tRNA substrate puromycin supports an intermediate (hybrid) state of tRNA binding. RNA 10: 102-13
    PubMed Link | Link to Article
  80. Cukras AR, Southworth DR, Brunelle JL, Culver GM, Green R. (2003) Ribosomal proteins S12 and S13 function as control elements for translocation of the mRNA:tRNA complex. Mol Cell 12: 321-8
    PubMed Link
  81. Southworth DR, Green R. (2003) Ribosomal translocation: sparsomycin pushes the button. Curr Biol 13: R652-4
    PubMed Link
  82. Southworth DR, Brunelle JL, Green R. (2002) EFG-independent translocation of the mRNA:tRNA complex is promoted by modification of the ribosome with thiol-specific reagents. J Mol Biol 324: 611-23
    PubMed Link
  83. Green R, Lorsch JR. (2002) The path to perdition is paved with protons. Cell 110: 665-8
    PubMed Link
  84. Semrad K, Green R. (2002) Osmolytes stimulate the reconstitution of functional 50S ribosomes from in vitro transcripts of Escherichia coli 23S rRNA. RNA 8: 401-11
    PubMed Link | Link to Article
  85. Thompson J, Kim DK, O'Connor M, Lieberman KR, Bayfield MA, Gregory ST, Green R, Noller HF, and Dahlberg AE. (2001) Analysis of mutations at residues A2451 and G2447 of 23S rRNA in the peptidyl transferase active site of the 50S ribosomal subunit. Proc. Natl. Acad. Sci 98(16): 9002-7. PubMed
  86. Kim DF, and Green R. Base-pairing between 23S rRNA and tRNA in the ribosomal A site. Mol. Cell 1999(4): 859-64. PubMed
  87. Sardesai NY, Green, and Schimmel P. (1999) Efficient 50S Ribosome-catalyzed peptide bond synthesis with an aminoacyl helix. Biochem 38(37): 12080-8. PubMed
  88. Khaitovich P, Tenson T, Mankin AS, and Green R. (1999) Peptidyl transferase activity catalyzed by proteinfree 23S ribosomal RNA remains elusive. RNA 5(5): 605-8 PubMed
  89. Khaitovich P, Mankin AS, Green R, Lancaster L, and Noller HF. (1999) Characterization of functionally active subribosomal particles from Thermus aquaticus. Proc. Natl. Acad. Sci. U.S.A. 96(1): 85-90 PubMed
  90. Green R, and Noller HF. (1999) Reconstitution of functional 50S ribosomes from in vitro transcripts of Bacillus stearothermophilus 23S rRNA. Biochem 38(6): 1772-9. PubMed
  91. Green R, Switzer C, and Noller HF. (1998) Ribosome-catalyzed peptide-bond formation with an A-site substrate covalently linked to 23S ribosomal RNA. Science 280(5361): 286-9 PubMed
  92. Puglisi EV, Green R, Noller HF, and Puglisi JD. (1997) Structure of a conserved RNA component of the peptidyl transferase centre. Nat. Struct. Biol. 4(10): 775-8 PubMed
  93. Green R, Samaha RR, and Noller HF. (1997) Mutations at nucleotides G2251 and U2585 of 23 S rRNA perturb the peptidyl transferase center of the ribosome. J. Mol. Biol. 266(1): 40-50 PubMed
  94. Green R, and Noller HF. (1997) Ribosomes and translation. Annu. Rev. Biochem. 66(1): 679-716 PubMed
  95. von Ahsen U, Green R, Schroeder R, and Noller HF. (1997) Identification of 2'-hydroxyl groups required for interaction of a tRNA anticodon stem-loop region with the ribosome. RNA 3(1): 49-56 PubMed
  96. Green R, and Noller HF. (1996) In vitro complementation analysis localizes 23S rRNA posttranscriptional modifications that are required for Escherichia coli 50S ribosomal subunit assembly and function. RNA 2(10): 1011-21 PubMed
  97. Noller HF, Green R, Heilek G, Hoffarth V, Hüttenhofer A, Joseph S, Lee I, Lieberman K, Mankin A, and Merryman C. (1996) Structure and function of ribosomal RNA. Biochem. Cell Biol. 73(11-12): 997-1009 PubMed
  98. Samaha RR, Green R, and Noller HF. (1995) A base pair between tRNA and 23S rRNA in the peptidyl transferase centre of the ribosome. Nature 377(6547): 309-14 PubMed
  99. Green R, and Szostak JW. (1994) In vitro genetic analysis of the hinge region between helical elements P5-P4- P6 and P7-P3-P8 in the sunY group I self-splicing intron. J. Mol. Biol 235(1): 140-55. PubMed
  100. Kumar Y, Green R, Wise DS, Wotring LL, and Townsend LB. (1993) Synthesis of 2,4-disubstituted thiazoles and selenazoles as potential antifilarial and antitumor agents. 2. 2-Arylamido and 2-alkylamido derivatives of 2-amino-4-(isothiocyanatomethyl)thiazole and 2-amino-4-(isothiocyanatomethyl)selenazole. J. Med. Chem 36(24): 3849-52. PubMed
  101. Kumar Y, Green R, Wise DS, Wotring LL, and Townsend LB. (1993) Synthesis of 2,4-disubstituted thiazoles and selenazoles as potential antifilarial and antitumor agents. 1. Methyl 4-(Isothiocyanatomethyl)thiazole-2- carbamates, -selenazole-2-carbamates, and related derivatives. J. Med. Chem 36(24): 3843-8. PubMed
  102. Green R, and Szostak JW. (1992) Selection of a ribozyme that functions as a superior template in a self-copying reaction. Science 258(5090): 1910-5. PubMed