Review Articles:

7. Nihongaki Y. "Dynamic molecular mechanism of primary cilia disassembly" Experimental Medicine [in Japanese] (2018) 

6. Niu J., Ben Johny M., Dick I.E., Inoue T. "Following Optogenetic Dimerizers and Quantitative Prospects" Biophysical Journal (2016) PDF

5. Kim A.K., DeRose R., Ueno T., Lin B., Komatsu T., Nakamura H., Inoue T. "Toward total synthesis of cell function: Reconstituting cell dynamics with synthetic biology" Science Signaling (2016) PDF

4. Phua S., Lin Y., Inoue T. "An intelligent nano-antenna: Primary cilium harnesses TRP channels to decode polymodal stimuli"  Cell Calcium (2015) PDF

3. Lin Y.C., Phua S.C., Lin B.,, and Inoue T., "Visulaizing molecular diffusion through passive permeability barriers in cells: conventional and novel approaches" Curr. Opin. Chem Bio (2013) PDF

2. DeRose R. Miyamoto T. and Inoue T., “Manipulating signaling at will: chemically-inducible dimerization
(CID) techniques resolve problems in cell biology“ Pflügers Archiv (2013) PDF

1. Miyamoto T., Razavi S., DeRose R., and Inoue T. “Synthesizing Biomolecule-based Boolean Logic Gates” (In press) ACS Synthetic Biology PDF 
Note: Podcast (Audio); Author's Introduction PDF

Editorial Articles:

3. Inoue T. "A hair of cells that is old but new, and small but big" Experimental Medicine [in Japanese] (2018)

2. Gaus K., Inoue T. "New Biological Frontiers Illuminated by Molecular Sensors and Actuators" Biophysical Journal (2016)

1. Miyamoto T., Rho E., and Inoue T.* “Deconvoluting AMPK Signaling” Oncotarget (In press)

Research Articles:

41. Nakamura H., Lee A.A., Sobhi Afshar A., Watanabe S., Rho E., Razavi S., Suarez A., Lin Y.C., Tanigawa M., Huang B., DeRose R., Bobb D., Hong W., Gabelli S.B., Goutsias J., Inoue T. "Intracellular production of hydrogels and synthetic RNA granules by multivalent molecular interactions" Nature Materials Advance Online Publication (2017) PDF

40. Phua S.C., Chiba S., Suzuki M., Su E., Roberson E.C., Pusapati G.V., Setou M., Rohatgi R., Reiter J.F., Ikegami K., Inoue T. "Dynamic Remodeling of Membrane Composition Drives Cell Cycles through Primary Celia Excision" Cell 168(1-2):264-279 (2017) PDF

39. Meier E.L., Razavi S., Inoue T., Goley E.D. "A Novel membrane anchor for FtsZ linked to cell wall hydrolysis in Caulobacter crescentus" Molecular Microbiology 101(2):265-80 (2016) PDF

38. Nguyen H-N., Miyamoto T., Yang, J-M., Inoue T., Sesaki H., Devreotes P.N., and Iijima M. “Opening the conformation is a master switch for the dual localization and phosphatase activity of PTEN” Scientific Reports 5, 12600 (2015) PDF

37. Garcia-Gonzalo F.R., Phua S.C., Roberson E.C., Galo Garcia III, Abedin M., Schurmans S., Inoue T.*, Jeremy F. Reiter* “Phosphoinositides Regulate Ciliary Protein Trafficking to Modulate Hedgehog Signaling” Developmental Cell 34, 400-409 (2015) PDF
Note: “Phosphoinositide Code for Primary Cilia” Preview by Developmental Cell

36. Antonczak A.K., Mullee L., Wang Y., Comartin D., Inoue T., Pelletier L. and Morrison C.G. "Opposing effects of pericentrin and microcephalin on the pericentriolar material regulate CHK1 activation in the DNA damage response" (in press, Oncogene) PDF

35. Miyamoto T., Rho E., Sample V., Akano H., Magari M., Ueno T., Gorshkov K., Chen M., Tokumitsu H., Zhang J., and Inoue T.* "Compartmentalized AMPK Signaling Illuminated by Genetically Encoded Molecular Sensors and Actuators" Cell Reports 11, 657-670 (2015) PDF

34. Lin B., Yin T., Wu Y., Inoue T., and Levchenko A. "Interplay between chemotaxis and contact inhibition of locomotion determines exploratory cell migration" Nature Communications (2015) PDF

33. Adams P.J., Johny M.B., Dick I.E., Inoue T., and Yue D.T., "Apocalmodulin itself promotes ion channel opening and Ca regulation" Cell 159(3), 608-622 (2014) PDF

32. Razavi S., Su S., and Inoue T. "Cellular Signaling Circuits Interfaced with Synthetic, Post-Translational, Negating Boolean Logic Devices" ACS Synthetic Biology (2014) PDF

31. Onuma H., Komatsu T., Arita M., Hanaoka K., Ueno T., Terai T., Nagano T., and Inoue T. "Rapidly rendering cells phagocytic through a cell surface display technique and concurrent Rac activation" Science Signaling (2014) PDF

30. Suarez A., Ueno T., Huebner R., McCaffery J.M., and Inoue T. "Bin/Amphiphysin/Rvs (BAR) family members bend membranes in cells" Scientific Reports (2014) PDF

29. Kobayashi T., Kim S., Lin Y.C., Inoue T., and Dynlacht B.D. "The CP110-interacting proteins Talpid3 and Cep290 play overlapping and distinct roles in cilia assembly" J. Cell Biol. (2014) PDF

28. Su S.*, Phua S.C.*, DeRose R., Chiba S., Narita K., Kalugin P.N., Katada T., Kontani K., Takeda S., and Inoue T. "Genetically encoded calcium indicator illuminates calcium dynamics in primary cilia" Nature Methods (2013) PDF

27. Thevathasan, J.V., Tan E., Hui Z., Lin Y.C., Li Y., Inoue T. and Fivaz M. “Local positive feedback from PI3K to Ras drives cell polarization and migration” Molecular Biology of the Cell (in press)

26. Y.C. Lin, P. Niewiadomski, B. Lin, H. Nakamura, S.C. Phua, J. Jiao, A. Levchenko, T. Inoue, R. Rohatgi, and T. Inoue “Chemically-inducible diffusion trap reveals molecular sieve-like barrier at primary cilia“ Nature Chemical Biology PDF

25. Lin YC, Nihongaki Y, Liu T-Y, Razavi S, Sato M, and Inoue T. “Rapidly Reversible Manipulation of Molecular Activities Using Dual Chemical Dimerizers” Angewandte Chemie PDF

24. Lin B., Wang J., Ueno T., Harwell A., Inoue T.* and Levchenko A.* “Synthetic spatially graded Rac activation drives directed cell polarization and locomotion“ PNAS 109, E3668 (2012) PDF
Note: “Origin of Disease” Interview by TV science program (NHK Japanese broadcasting company, May 2013 on air), “Rac Gets Cells on Track” Introductory article by Cell Migration Gateway, News and Views by “Biofutur”

23. Sample V., Ni Q., Inoue T. and Zhang J. “Controlling Enzymatic Action in Living Cells with a Kinase-dependent Bimolecular Switch” ACS Chemical Biology PDF

22. Phua S.C., Pohlmeyer C., and Inoue T. "Rapdily Relocating Molecules Between Organelles to Manipulate Small GTPase Activity" ACS Chemical Biology (2012) PDF 
Note: Podcast (Audio)

21. Miyamoto T.*, DeRose R.*, Suarez A., Ueno T., Chen M., Sun T., Wolfgang M., Mukherjee C., Meyers D., and Inoue T.“Rapid and Orthogonal Logic Gating with a Novel Gibberellin-Induced Dimerization System” Nature Chemical Biology (2012) PDF
Note: “Tools in Brief”, (Nature Methods, 9, 534 (2012), “Rapamycin’s Sister”), “Interview” by TV Science Channel, Karga7 Pictures, “This Changes Everything” (2012), Press Release: “Researchers Turn Living Cells Into Logic Gates, Moving Toward Cell Circuits “ (“TRENDING”, at SLATE) 

20. DeRose R.*, Pohlmeyer C.*, Umeda N.*, Ueno T., Nagano T., Kuo S., and Inoue T. “Moving molecules by light; Spatio-temporal manipulation of small GTPase activity at subcellular level and on timescale of seconds in living cells” Journal of Visualized Experiments (2012) VIDEO

19. Ueno T., Falkenburger B.H., Pohlmeyer C., and Inoue T.“Triggering Actin Comets Versus Membrane Ruffles: Distinctive Effects of Phosphoinositides on Actin Reorganization” Science Signaling 4(203), ra87 (2011) PDF
Note: “Perspective”, (Science Signaling, 5, pe7 (2012), “How Actin Gets the PIP”), “Editorial Guides” (Science Signaling, 5, eg3 (2012), “A Sense of Direction”), Press release: ”Rearranging the Cell's Skeleton” (Biochemist e-VOLUTION” at Biochemical Society), Featured in F1000, Selected for Cover Article

18. Komatsu T., Johnsson K., Okuno H., Bito H., Inoue T., Nagano T. and Urano Y. “Real-time measurements of protein dynamics using fluorescence activation-coupled protein labeling (FAPL) method” Journal of American Chemical Society 133, 6745-6751 (2011) PDF

17. Umeda N.*, Ueno T* Pohlmeyer C., Nagano T. and Inoue T. “A photocleavable rapamycin conjugate for spatiotemporal control of small GTPase activity” Journal of American Chemical Society 133(1), 12-14 (2011) PDF
Note: Press Release, “Scientist use light to move molecules within living cells” ("Science News" at ScienceDaily) 

16. Komatsu T.*, Kukelyansky I.*, McCaffery J.M., Ueno T., Varela L.C. and Inoue T. “Organelle-Specific, Rapid Induction of Molecular Activities and Membrane Tethering” Nature Methods 7, 206-208 (2010) PDF
Note: "Breaking News" (Genetic Engineering and Biotechnology News "Hopkins researchers put proteins right where they want them"), Selected for 2013 calandar by ibidi 

15. Rahdar M., Inoue T., Meyer T., Zhang J., Vazquez F., and Devreotes P.N. “A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN” Proc. Natl. Acad. Sci. U S A. 106(2):480-5 (2009) PDF

14. Inoue T. and Meyer T. “Synthetic activation of endogenous PI3K and Rac identifies an AND-gate switch for cell polarization and migration” PLoS ONE 3(8), e3068 (2008) PDF

13. Yogo T., Urano Y., Mizushima A., Sunahara H., Inoue T., Hirose K., Iino M., Kikuchi K., and Nagano T. "Selective photoinactivation of protein function through environment-sensitive switching of singlet oxygen generation by photosensitizer" Proc. Natl. Acad. Sci. U S A. 105, 28-32 (2008) PDF

12. Fivaz M., Bandara S., Inoue T. and Meyer T. "Robust neuronal symmetry breaking by Ras-triggered local positive feedback" Current Biology 18, 44-50 (2008) PDF

11. Abe N., Klein L., Inoue T., Galvez T., and Meyer T. “Dissecting the role of PI(4,5)P2 in transferrin receptor endocytosis and recycling” Journal of Cell Science 121, 1488 (2008) PDF

10. Aoki. K, Nakamura T, Inoue T, Meyer T, and Matsuda M. “An essential role for the SHIP2-dependent negative feedback loop in neuritogenesis of nerve growth factor–stimulated PC12 cells” Journal of Cell Biology 177, 817-827 (2007) PDF

9. Liou J, Fivaz M, Inoue T, and Meyer T. “Live-cell imaging reveals sequential oligomerization and local PM targeting of STIM1 following Ca2+ store depletion” Proc. Natl. Acad. Sci. U S A. 104, 9301-9306 (2007)
Note: “Research Roundup” (J. Cell Biol. 177 (6), (2007)). PDF

8. Suh BC*, Inoue T*, Meyer T, and Hille B. “Rapid chemically-induced changes of PtdIns(4,5)P2 gate KCNQ ion channels” Science 314, 1454-1457 (2006) (*Contributed Equally)
Note: “Perspectives” (Science 314, 1402-1403 (2006)), “Editor’s Choice” (Science STKE 364, tw410 (2006)), “Spotlight” (ACS Chem. Biol. 1, 608 (2006)), “Research Highlights” (Nature Methods 4, 7 (2007)) PDF

7. Heo WD, Inoue T, Park WS, Kim ML, Park BO, Wandless TJ, and Meyer T. “PI(3,4,5)P3 and PI(4,5)P2 lipids target Ras, Rho, Arf and Rab GTPases to the plasma membrane” Science 314, 1458-1461 (2006) PDF

6. Inoue T, Heo WD, Grimley JS, Wandless TJ, and Meyer T. “Inducible translocation strategies to rapidly activate and inhibit small GTPase signaling pathways” Nature Methods 2, 415-418 (2005) PDF

5. Yogo T, Kikuchi K, Inoue T, Hirose K, Iino M, and Nagano T. “Modification of intracellular Ca2+ dynamics by laser inactivation of inositol 1,4,5-trisphosphate receptor using membrane-permeant probes.” Chem. Biol. 11, 1053-1058 (2004) PDF

4. Inoue T, Kikuchi K, Hirose K, Iino M, and Nagano T. “Spatiotemporal Laser Inactivation of Inositol 1,4,5-Trisphosphate Receptors Using Synthetic Small-molecule Probes” Chem. Biol. 10, 503-509 (2003)
Note: “Cover art” PDF

3. Nakanishi W, Kikuchi K, Inoue T, Hirose K, Iino M, and Nagano T. “Hydrophobic modifications at 1-phosphate of inositol 1,4,5-trisphosphate analogues enhance receptor binding” Bioorg. Med. Chem. Lett. 12, 911-913 (2002) PDF

2. Inoue T, Kikuchi K, Hirose K, Iino M, and Nagano T. “Small molecule-based laser inactivation of inositol 1,4,5-trisphosphate receptor” Chem. Biol. 8, 9-15 (2001) PDF

1. Inoue T, Kikuchi K, Hirose K, Iino M, and Nagano T. “Synthesis and evaluation of 1-position-modified inositol 1,4,5-trisphosphate analogs” Bioorg. Med. Chem. Lett. 9, 1697-1702 (1999) PDF


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