Johns Hopkins University
Department of Biomedical Engineering
Institute of Computational Medicine
  1. S. Zahid, K. Whyte, E. Schwarz, R. Blake, P. Boyle, J. Chrispin, A. Prakosa, E. Ipek, F. Pashakhanloo, H. Halperin, H. Calkins, R. Berger, S. Nazarian, N. Trayanova. Feasibility of using patient-specific models and the "minimum cut" algorithm to predict optimal ablation targets for left atrial flutter. Heart Rhythm. 13(8): 1687-98, Aug 2016. [ LINK ]

  2. H. Arevalo, P. Boyle, N. Trayanova. Computational rabbit models to investigate the initiation, perpetuation, and termination of ventricular arrhythmia. Prog Biophys Mol Biol. 121(2): 185-94, Jul 2016. [ LINK ]

  3. S. Zahid, H. Cochet, P. Boyle, E. Schwarz, K. Whyte, E. Vigmond, R. Dubois, M. Hocini, M. Haïssaguerre, P. Jaïs, N. Trayanova. Patient-derived models link re-entrant driver localization in atrial fibrillation to fibrosis spatial pattern. Cardiovasc Res. 110(3): 443-54, 1 Jun 2016. [ LINK ]

  4. E. Ukwatta, H. Arevalo, K. Li, J. Yuan, W. Qiu, P. Malamas, K. Wu, N. Trayanova, F. Vadakkumpadan. Myocardial Infarct Segmentation From Magnetic Resonance Images for Personalized Modeling of Cardiac Electrophysiology. IEEE Trans Med Imaging. 35(6): 1408-19, Jun 2016. [ LINK ]

  5. K. McDowell, S. Zahid, F. Vadakkumpadan, J. Blauer, R. MacLeod, N. Trayanova. Correction: Virtual Electrophysiological Study of Atrial Fibrillation in Fibrotic Remodeling. PLoS One. 11(5): e0156189, 20 May 2016. [ LINK ]

  6. J. Bayer, G. Lalani, E. Vigmond, S. Narayan, N. Trayanova. Mechanisms linking electrical alternans and clinical ventricular arrhythmia in human heart failure. Heart Rhythm. 20 May 2016. [ LINK ]

  7. Y. Zhang, V. Barocas, S. Berceli, C. Clancy, D. Eckmann, M. Garbey, G. Kassab, D. Lochner, A. McCulloch, R. Tran-Son-Tay, N. Trayanova. Multi-scale Modeling of the Cardiovascular System: Disease Development, Progression, and Clinical Intervention. Ann Biomed Eng. 2 May 2016. [ LINK ]

  8. N. Trayanova, K. Chang. How computer simulations of the human heart can improve anti-arrhythmia therapy. J Physiol. 594(9): 2483-502, 1 May 2016. [ LINK ]

  9. M. Haissaguerre, A. Shah, H. Cochet, M. Hocini, R. Dubois, I. Efimov, E. Vigmond, O. Bernus, N. Trayanova. Intermittent drivers anchoring to structural heterogeneities as a major pathophysiological mechanism of human persistent atrial fibrillation. J Physiol. 594(9): 2387-98, 1 May 2016. [ LINK ]

  10. F. Pashakhanloo, D. Herzka, H. Ashikaga, S. Mori, N. Gai, D. Bluemke, N. Trayanova, E. McVeigh. Myofiber Architecture of the Human Atria as Revealed by Submillimeter Diffusion Tensor Imaging. Circ Arrhythm Electrophysiol. 9(4): e004133, Apr 2016. [ LINK ]

  11. T. Karathanos, J. Bayer, D. Wang, P. Boyle, N. Trayanova. Opsin spectral sensitivity determines the effectiveness of optogenetic termination of ventricular fibrillation in the human heart: A simulation study. J Physiol. 4 Mar 2016. [ LINK ]

  12. J. Chrispin, E. Gucuk Ipek, S. Zahid, A. Prakosa, M. Habibi, D. Spragg, J. Marine, H. Ashikaga, J. Rickard, N. Trayanova, S. Zimmerman, V. Zipunnikov, R. Berger, H. Calkins, S. Nazarian. Lack of regional association between atrial late gadolinium enhancement on cardiac magnetic resonance and atrial fibrillation rotors. Heart Rhythm. 13(3): 654-60, Mar 2016. [ LINK ]

  13. K. Fukumoto, M. Habibi, E. Ipek, S. Zahid, I. Khurram, S. Zimmerman, V. Zipunnikov, D. Spragg, H. Ashikaga, N. Trayanova, G. Tomaselli, J. Rickard, J. Marine, R. Berger, H. Calkins, S. Nazarian. Association of Left Atrial Local Conduction Velocity With Late Gadolinium Enhancement on Cardiac Magnetic Resonance in Patients With Atrial Fibrillation. Circ Arrhythm Electrophysiol. 9(3): e002897, Mar 2016. [ LINK ]

  14. J. Molitoris, S. Paliwal, R. Sekar, R. Blake, J. Park, N. Trayanova, L. Tung, A. Levchenko. Precisely parameterized experimental and computational models of tissue organization. Integr Biol (Camb). 8(2): 230-42, Feb 2016. [ LINK ]

  15. M. Zile, N. Trayanova. Rate-dependent force, intracellular calcium, and action potential voltage alternans are modulated by sarcomere length and heart failure induced-remodeling of thin filament regulation in human heart failure: A myocyte modeling study. Prog Biophys Mol Biol. 120(1-3): 270-80, Jan 2016. [ LINK ]

  16. H. Arevalo, F. Vadakkumpadan, E. Guallar, A. Jebb, P. Malamas, K. Wu, N. Trayanova. Arrhythmia risk stratification of patients after myocardial infarction using personalized heart models. Nat Commun. 7: 11437, 2016. [ LINK ]

  17. S. Land, V. Gurev, S. Arens, C. Augustin, L. Baron, R. Blake, C. Bradley, S. Castro, A. Crozier, M. Favino, T. Fastl, T. Fritz, H. Gao, A. Gizzi, B. Griffith, D. Hurtado, R. Krause, X. Luo, M. Nash, S. Pezzuto, G. Plank, S. Rossi, D. Ruprecht, G. Seemann, N. Smith, J. Sundnes, J. Rice, N. Trayanova, D. Wang, Z. Jenny Wang, S. Niederer. Verification of cardiac mechanics software: benchmark problems and solutions for testing active and passive material behaviour. Proc Math Phys Eng Sci. 471(2184): 20150641, 8 Dec 2015. [ LINK ]

  18. P. Boyle, T. Karathanos, E. Entcheva, N. Trayanova. Computational modeling of cardiac optogenetics: Methodology overview & review of findings from simulations. Comput Biol Med. 65: 200-8, 1 Oct 2015. [ LINK ]

  19. E. Ukwatta, H. Arevalo, M. Rajchl, J. White, F. Pashakhanloo, A. Prakosa, D. Herzka, E. McVeigh, A. Lardo, N. Trayanova, F. Vadakkumpadan. Image-based reconstruction of three-dimensional myocardial infarct geometry for patient-specific modeling of cardiac electrophysiology. Med Phys. 42(8): 4579-90, Aug 2015. [ LINK ]

  20. P. Ping, Å. Gustafsson, D. Bers, L. Blatter, H. Cai, A. Jahangir, D. Kelly, D. Muoio, B. O'Rourke, P. Rabinovitch, N. Trayanova, J. Van Eyk, J. Weiss, R. Wong, L. Schwartz Longacre. Harnessing the Power of Integrated Mitochondrial Biology and Physiology: A Special Report on the NHLBI Mitochondria in Heart Diseases Initiative. Circ Res. 117(3): 234-8, 17 Jul 2015. [ LINK ]

  21. K. Khrapko, N. Trayanova, S. Nattel. Modeling the aging heart: from local respiratory defects to global rhythm disturbances. Cell Metab. 21(5): 662-3, 5 May 2015. [ LINK ]

  22. K. Lim, S. Hong, B. Lee, E. Shim, N. Trayanova. Computational analysis of the effect of valvular regurgitation on ventricular mechanics using a 3D electromechanics model. J Physiol Sci. 65(2): 159-64, Mar 2015. [ LINK ]

  23. E. Ukwatta, M. Rajchl, J. White, F. Pashakhanloo, D. Herzka, E. McVeigh, A. Lardo, N. Trayanova, F. Vadakkumpadan. Image-based Reconstruction of 3D Myocardial Infarct Geometry for Patient Specific Applications. Proc SPIE Int Soc Opt Eng. 9413: , 21 Feb 2015. [ LINK ]

  24. P. Boyle, T. Karathanos, N. Trayanova. "Beauty is a light in the heart": the transformative potential of optogenetics for clinical applications in cardiovascular medicine. Trends Cardiovasc Med. 25(2): 73-81, Feb 2015. [ LINK ]

  25. E. Ukwatta, M. Rajchl, J. White, F. Pashakhanloo, D. Herzka, E. McVeigh, A. Lardo, N. Trayanova, F. Vadakkumpadan. Image-based reconstruction of 3D myocardial infarct geometry for patient specific applications. Proc. SPIE 9413, Medical Imaging 2015: Image Processing. 94132W, 2015.

  26. K. McDowell, S. Zahid, F. Vadakkumpadan, J. Blauer, R. MacLeod, N. Trayanova. Virtual electrophysiological study of atrial fibrillation in fibrotic remodeling. PLoS One. 10(2): e0117110, 2015. [ LINK ]

  27. Y. Choi, J. Constantino, V. Vedula, N. Trayanova, R. Mittal. A New MRI-Based Model of Heart Function with Coupled Hemodynamics and Application to Normal and Diseased Canine Left Ventricles. Front Bioeng Biotechnol. 3: 140, 2015. [ LINK ]

  28. D. Deng, H. Arevalo, F. Pashakhanloo, A. Prakosa, H. Ashikaga, E. McVeigh, H. Halperin, N. Trayanova. Accuracy of prediction of infarct-related arrhythmic circuits from image-based models reconstructed from low and high resolution MRI. Front Physiol. 6: 282, 2015. [ LINK ]

  29. C. Ambrosi, P. Boyle, K. Chen, N. Trayanova, E. Entcheva. Optogenetics-enabled assessment of viral gene and cell therapy for restoration of cardiac excitability. Sci Rep. 5: 17350, 2015. [ LINK ]

  30. K. Chang, J. Bayer, N. Trayanova. Disrupted calcium release as a mechanism for atrial alternans associated with human atrial fibrillation. PLoS Comput Biol. 10(12): e1004011, Dec 2014. [ LINK ]

  31. T. Karathanos, P. Boyle, N. Trayanova. Optogenetics-enabled dynamic modulation of action potential duration in atrial tissue: feasibility of a novel therapeutic approach. Europace. 16 Suppl 4: iv69-iv76, Nov 2014. [ LINK ]

  32. F. Vadakkumpadan, N. Trayanova, K. Wu. Image-based left ventricular shape analysis for sudden cardiac death risk stratification. Heart Rhythm. 11(10): 1693-700, Oct 2014. [ LINK ]

  33. A. Prakosa, P. Malamas, S. Zhang, F. Pashakhanloo, H. Arevalo, D. Herzka, A. Lardo, H. Halperin, E. McVeigh, N. Trayanova, F. Vadakkumpadan. Methodology for image-based reconstruction of ventricular geometry for patient-specific modeling of cardiac electrophysiology. Prog Biophys Mol Biol. 115(2-3): 226-34, Aug 2014. [ LINK ]

  34. Y. Hu, V. Gurev, J. Constantino, N. Trayanova. Optimizing cardiac resynchronization therapy to minimize ATP consumption heterogeneity throughout the left ventricle: a simulation analysis using a canine heart failure model. Heart Rhythm. 11(6): 1063-9, Jun 2014. [ LINK ]

  35. N. Trayanova, L. Rantner. New insights into defibrillation of the heart from realistic simulation studies. Europace. 16(5): 705-13, May 2014. [ LINK ]

  36. N. Trayanova. Mathematical approaches to understanding and imaging atrial fibrillation: significance for mechanisms and management. Circ Res. 114(9): 1516-31, 25 Apr 2014. [ LINK ]

  37. P. Wright, V. Nikolaev, T. O'Hara, I. Diakonov, A. Bhargava, S. Tokar, S. Schobesberger, A. Shevchuk, M. Sikkel, R. Wilkinson, N. Trayanova, A. Lyon, S. Harding, J. Gorelik. Caveolin-3 regulates compartmentation of cardiomyocyte beta2-adrenergic receptor-mediated cAMP signaling. J Mol Cell Cardiol. 67: 38-48, Feb 2014. [ LINK ]

  38. L. Zhou, S. Solhjoo, B. Millare, G. Plank, M. Abraham, S. Cortassa, N. Trayanova, B. O'Rourke. Effects of regional mitochondrial depolarization on electrical propagation: implications for arrhythmogenesis. Circ Arrhythm Electrophysiol. 7(1): 143-51, Feb 2014. [ LINK ]

  39. N. Trayanova, P. Boyle. Advances in modeling ventricular arrhythmias: from mechanisms to the clinic. Wiley Interdiscip Rev Syst Biol Med. 6(2): 209-24, 1 Jan 2014. [ LINK ]

  40. P. Boyle, E. Entcheva, N. Trayanova. See the light: can optogenetics restore healthy heartbeats? And, if it can, is it really worth the effort? Expert Rev Cardiovasc Ther. 12(1): 17-20, Jan 2014. [ LINK ]

  41. N. Trayanova. Virtual 3D heart models to aid pacemaker implantation in children. Future Cardiol. 10(1): 5-8, Jan 2014. [ LINK ]

  42. N. Smith, N. Trayanova. Computational models of heart disease. Drug Discov Today Dis Models. 14: 1-2, 2014. [ LINK ]

  43. P. Boyle, C. Park, H. Arevalo, E. Vigmond, N. Trayanova. Sodium current reduction unmasks a structure-dependent substrate for arrhythmogenesis in the normal ventricles. PLoS One. 9(1): e86947, 2014. [ LINK ]

  44. N. Trayanova, P. Boyle, H. Arevalo, S. Zahid. Exploring susceptibility to atrial and ventricular arrhythmias resulting from remodeling of the passive electrical properties in the heart: a simulation approach. Front Physiol. 5: 435, 2014. [ LINK ]

  45. E. Ukwatta, J. Yuan, W. Qiu, K. Wu, N. Trayanova, F. Vadakkumpadan. Myocardial infarct segmentation and reconstruction from 2D late-gadolinium enhanced magnetic resonance images. Med Image Comput Comput Assist Interv. 17(Pt 2): 554-61, 2014. [ LINK ]

  46. J. Ringenberg, M. Deo, D. Filgueiras-Rama, G. Pizarro, B. Ibañez, R. Peinado, N. Trayanova, M. Miller, J. Merino, O. Berenfeld, V. Devabhaktuni. Corrigendum to "effects of fibrosis morphology on reentrant ventricular tachycardia inducibility and simulation fidelity in patient-derived models". Clin Med Insights Cardiol. 8(Suppl 1): 51, 2014. [ LINK ]

  47. Y. Hu, V. Gurev, J. Constantino, N. Trayanova. Efficient preloading of the ventricles by a properly timed atrial contraction underlies stroke work improvement in the acute response to cardiac resynchronization therapy. Heart Rhythm. 10(12): 1800-6, Dec 2013. [ LINK ]

  48. J. Constantino, Y. Hu, A. Lardo, N. Trayanova. Mechanistic insight into prolonged electromechanical delay in dyssynchronous heart failure: a computational study. Am J Physiol Heart Circ Physiol. 305(8): H1265-73, 15 Oct 2013. [ LINK ]

  49. L. Rantner, F. Vadakkumpadan, P. Spevak, J. Crosson, N. Trayanova. Placement of implantable cardioverter-defibrillators in paediatric and congenital heart defect patients: a pipeline for model generation and simulation prediction of optimal configurations. J Physiol. 591(17): 4321-34, 1 Sep 2013. [ LINK ]

  50. H. Ashikaga, H. Arevalo, F. Vadakkumpadan, R. Blake, J. Bayer, S. Nazarian, M. Muz Zviman, H. Tandri, R. Berger, H. Calkins, D. Herzka, N. Trayanova, H. Halperin. Feasibility of image-based simulation to estimate ablation target in human ventricular arrhythmia. Heart Rhythm. 10(8): 1109-16, Aug 2013. [ LINK ]

  51. L. Rantner, B. Tice, N. Trayanova. Terminating ventricular tachyarrhythmias using far-field low-voltage stimuli: mechanisms and delivery protocols. Heart Rhythm. 10(8): 1209-17, Aug 2013. [ LINK ]

  52. K. McDowell, F. Vadakkumpadan, R. Blake, J. Blauer, G. Plank, R. Macleod, N. Trayanova. Mechanistic inquiry into the role of tissue remodeling in fibrotic lesions in human atrial fibrillation. Biophys J. 104(12): 2764-73, 18 Jun 2013. [ LINK ]

  53. X. Chen, L. Tereshchenko, R. Berger, N. Trayanova. Arrhythmia risk stratification based on QT interval instability: an intracardiac electrocardiogram study. Heart Rhythm. 10(6): 875-80, Jun 2013. [ LINK ]

  54. S. Weinberg, K. Chang, R. Zhu, H. Tandri, R. Berger, N. Trayanova, L. Tung. Defibrillation success with high frequency electric fields is related to degree and location of conduction block. Heart Rhythm. 10(5): 740-8, May 2013. [ LINK ]

  55. N. Trayanova. In the spotlight: Cardiovascular engineering. IEEE Rev Biomed Eng. 6: 19-20, 2013. [ LINK ]

  56. F. Vadakkumpadan, H. Arevalo, N. Trayanova. Patient-specific modeling of the heart: estimation of ventricular fiber orientations. J Vis Exp. 2013. [ LINK ]

  57. Y. Hu, V. Gurev, J. Constantino, J. Bayer, N. Trayanova. Effects of mechano-electric feedback on scroll wave stability in human ventricular fibrillation. PLoS One. 8(4): e60287, 2013. [ LINK ]

  58. H. Arevalo, G. Plank, P. Helm, H. Halperin, N. Trayanova. Tachycardia in post-infarction hearts: insights from 3D image-based ventricular models. PLoS One. 8(7): e68872, 2013. [ LINK ]

  59. P. Boyle, J. Williams, C. Ambrosi, E. Entcheva, N. Trayanova. A comprehensive multiscale framework for simulating optogenetics in the heart. Nat Commun. 4: 2370, 2013. [ LINK ]

  60. D. Krummen, J. Bayer, J. Ho, G. Ho, M. Smetak, P. Clopton, N. Trayanova, S. Narayan. Mechanisms of human atrial fibrillation initiation: clinical and computational studies of repolarization restitution and activation latency. Circ Arrhythm Electrophysiol. 5(6): 1149-59, Dec 2012. [ LINK ]

  61. N. Trayanova, T. O'Hara, J. Bayer, P. Boyle, K. McDowell, J. Constantino, H. Arevalo, Y. Hu, F. Vadakkumpadan. Computational cardiology: how computer simulations could be used to develop new therapies and advance existing ones. Europace. 14 Suppl 5: v82-v89, Nov 2012. [ LINK ]

  62. R. Winslow, N. Trayanova, D. Geman, M. Miller. Computational medicine: translating models to clinical care. Sci Transl Med. 4(158): 158rv11, 31 Oct 2012. [ LINK ]

  63. J. Bayer, R. Blake, G. Plank, N. Trayanova. A novel rule-based algorithm for assigning myocardial fiber orientation to computational heart models. Ann Biomed Eng. 40(10): 2243-54, Oct 2012. [ LINK ]

  64. K. McDowell, F. Vadakkumpadan, R. Blake, J. Blauer, G. Plank, R. MacLeod, N. Trayanova. Methodology for patient-specific modeling of atrial fibrosis as a substrate for atrial fibrillation. J Electrocardiol. 45(6): 640-5, 25 Sep 2012. [ LINK ]

  65. L. Rantner, H. Arevalo, J. Constantino, I. Efimov, G. Plank, N. Trayanova. Three-dimensional mechanisms of increased vulnerability to electric shocks in myocardial infarction: altered virtual electrode polarizations and conduction delay in the peri-infarct zone. J Physiol. 590(18): 4537-51, 15 Sep 2012. [ LINK ]

  66. J. Constantino, Y. Hu, N. Trayanova. A computational approach to understanding the cardiac electromechanical activation sequence in the normal and failing heart, with translation to the clinical practice of CRT. Prog Biophys Mol Biol. 110(2-3): 372-9, 14 Aug 2012. [ LINK ]

  67. X. Chen, N. Trayanova. A novel methodology for assessing the bounded-input bounded-output instability in QT interval dynamics: application to clinical ECG with ventricular tachycardia. IEEE Trans Biomed Eng. 59(8): 2111-7, Aug 2012. [ LINK ]

  68. F. Vadakkumpadan, H. Arevalo, C. Ceritoglu, M. Miller, N. Trayanova. Image-based estimation of ventricular fiber orientations for personalized modeling of cardiac electrophysiology. IEEE Trans Med Imaging. 31(5): 1051-60, May 2012. [ LINK ]

  69. T. Ashihara, R. Haraguchi, K. Nakazawa, T. Namba, T. Ikeda, Y. Nakazawa, T. Ozawa, M. Ito, M. Horie, N. Trayanova. The role of fibroblasts in complex fractionated electrograms during persistent/permanent atrial fibrillation: implications for electrogram-based catheter ablation. Circ Res. 110(2): 275-84, 20 Jan 2012. [ LINK ]

  70. M. Yamazaki, H. Honjo, T. Ashihara, M. Harada, I. Sakuma, K. Nakazawa, N. Trayanova, M. Horie, J. Kalifa, J. Jalife, K. Kamiya, I. Kodama. Regional cooling facilitates termination of spiral-wave reentry through unpinning of rotors in rabbit hearts. Heart Rhythm. 9(1): 107-14, Jan 2012. [ LINK ]

  71. K. Lim, J. Constantino, V. Gurev, R. Zhu, E. Shim, N. Trayanova. Comparison of the effects of continuous and pulsatile left ventricular-assist devices on ventricular unloading using a cardiac electromechanics model. J Physiol Sci. 62(1): 11-9, Jan 2012. [ LINK ]

  72. V. Gurev, K. Tavakolian, J. Constantino, B. Kaminska, A. Blaber, N. Trayanova. Mechanisms Underlying Isovolumic Contraction and Ejection Peaks in Seismocardiogram Morphology. J Med Biol Eng. 32(2): 103-110, 2012. [ LINK ]

  73. N. Trayanova. Computational cardiology: the heart of the matter. ISRN Cardiol. 2012: 269680, 2012. [ LINK ]

  74. F. Vadakkumpadan, N. Trayanova, L. Younes, K. Wu. Left-ventricular shape analysis for predicting sudden cardiac death risk. Conf Proc IEEE Eng Med Biol Soc. 2012: 4067-70, 2012. [ LINK ]

  75. X. Chen, Y. Hu, B. Fetics, R. Berger, N. Trayanova. Unstable QT interval dynamics precedes ventricular tachycardia onset in patients with acute myocardial infarction: a novel approach to detect instability in QT interval dynamics from clinical ECG. Circ Arrhythm Electrophysiol. 4(6): 858-66, Dec 2011. [ LINK ]

  76. T. Quinn, S. Granite, M. Allessie, C. Antzelevitch, C. Bollensdorff, G. Bub, R. Burton, E. Cerbai, P. Chen, M. Delmar, D. Difrancesco, Y. Earm, I. Efimov, M. Egger, E. Entcheva, M. Fink, R. Fischmeister, M. Franz, A. Garny, W. Giles, T. Hannes, S. Harding, P. Hunter, G. Iribe, J. Jalife, C. Johnson, R. Kass, I. Kodama, G. Koren, P. Lord, V. Markhasin, S. Matsuoka, A. McCulloch, G. Mirams, G. Morley, S. Nattel, D. Noble, S. Olesen, A. Panfilov, N. Trayanova, U. Ravens, S. Richard, D. Rosenbaum, Y. Rudy, F. Sachs, F. Sachse, D. Saint, U. Schotten, O. Solovyova, P. Taggart, L. Tung, A. Varró, P. Volders, K. Wang, J. Weiss, E. Wettwer, E. White, R. Wilders, R. Winslow, P. Kohl. Minimum Information about a Cardiac Electrophysiology Experiment (MICEE): standardised reporting for model reproducibility, interoperability, and data sharing. Prog Biophys Mol Biol. 107(1): 4-10, Oct 2011. [ LINK ]

  77. H. Tandri, S. Weinberg, K. Chang, R. Zhu, N. Trayanova, L. Tung, R. Berger. Reversible cardiac conduction block and defibrillation with high-frequency electric field. Sci Transl Med. 3(102): 102ra96, 28 Sep 2011. [ LINK ]

  78. K. McDowell, H. Arevalo, M. Maleckar, N. Trayanova. Susceptibility to arrhythmia in the infarcted heart depends on myofibroblast density. Biophys J. 101(6): 1307-15, 21 Sep 2011. [ LINK ]

  79. J. Moreno, Z. Zhu, P. Yang, J. Bankston, M. Jeng, C. Kang, L. Wang, J. Bayer, D. Christini, N. Trayanova, C. Ripplinger, R. Kass, C. Clancy. A computational model to predict the effects of class I anti-arrhythmic drugs on ventricular rhythms. Sci Transl Med. 3(98): 98ra83, 31 Aug 2011. [ LINK ]

  80. N. Trayanova, J. Constantino, V. Gurev. Electromechanical models of the ventricles. Am J Physiol Heart Circ Physiol. 301(2): H279-86, Aug 2011. [ LINK ]

  81. V. Gurev, T. Lee, J. Constantino, H. Arevalo, N. Trayanova. Models of cardiac electromechanics based on individual hearts imaging data: image-based electromechanical models of the heart. Biomech Model Mechanobiol. 10(3): 295-306, Jun 2011. [ LINK ]

  82. H. Cetingül, G. Plank, N. Trayanova, R. Vidal. Estimation of local orientations in fibrous structures with applications to the Purkinje system. IEEE Trans Biomed Eng. 58(6): 1762-72, Jun 2011. [ LINK ]

  83. J. Provost, V. Gurev, N. Trayanova, E. Konofagou. Mapping of cardiac electrical activation with electromechanical wave imaging: an in silico-in vivo reciprocity study. Heart Rhythm. 8(5): 752-9, May 2011. [ LINK ]

  84. N. Trayanova. Whole-heart modeling: applications to cardiac electrophysiology and electromechanics. Circ Res. 108(1): 113-28, 7 Jan 2011. [ LINK ]

  85. N. Trayanova. Atrial defibrillation voltage: falling to a new low. Heart Rhythm. 8(1): 109-10, Jan 2011. [ LINK ]

  86. K. McDowell, N. Trayanova, P. Kohlo. Fibroblasts and cardiac electrophysiology. in: The Cardiac Fibroblast, pp 9-27. Ed. Neil A. Turner, Research Signpost, 2011.

  87. N. Trayanova, J. Rice. Cardiac electromechanical models: from cell to organ. Front Physiol. 2: 43, 2011. [ LINK ]

  88. F. Vadakkumpadan, H. Arevalo, C. Ceritoglu, M. Miller, N. Trayanova. Image-based estimation of ventricular fiber orientations for patient-specific simulations. Conf Proc IEEE Eng Med Biol Soc. 2011: 1672-5, 2011. [ LINK ]

  89. N. Trayanova. In the spotlight: cardiovascular engineering. IEEE Rev Biomed Eng. 4: 14-6, 2011. [ LINK ]

  90. N. Trayanova, J. Constantino, T. Ashihara, G. Plank. Modeling defibrillation of the heart: approaches and insights. IEEE Rev Biomed Eng. 4: 89-102, 2011. [ LINK ]

  91. G. Fishman, S. Chugh, J. Dimarco, C. Albert, M. Anderson, R. Bonow, A. Buxton, P. Chen, M. Estes, X. Jouven, R. Kwong, D. Lathrop, A. Mascette, J. Nerbonne, B. O'Rourke, R. Page, D. Roden, D. Rosenbaum, N. Sotoodehnia, N. Trayanova, Z. Zheng. Sudden cardiac death prediction and prevention: report from a National Heart, Lung, and Blood Institute and Heart Rhythm Society Workshop. Circulation. 122(22): 2335-48, 30 Nov 2010. [ LINK ]

  92. V. Gurev, J. Constantino, J. Rice, N. Trayanova. Distribution of electromechanical delay in the heart: insights from a three-dimensional electromechanical model. Biophys J. 99(3): 745-54, 4 Aug 2010. [ LINK ]

  93. J. Bayer, S. Narayan, G. Lalani, N. Trayanova. Rate-dependent action potential alternans in human heart failure implicates abnormal intracellular calcium handling. Heart Rhythm. 7(8): 1093-101, Aug 2010. [ LINK ]

  94. N. Trayanova, J. Constantino, V. Gurev. Models of stretch-activated ventricular arrhythmias. J Electrocardiol. 43(6): 479-85, 20 Jul 2010. [ LINK ]

  95. J. Constantino, Y. Long, T. Ashihara, N. Trayanova. Tunnel propagation following defibrillation with ICD shocks: hidden postshock activations in the left ventricular wall underlie isoelectric window. Heart Rhythm. 7(7): 953-61, Jul 2010. [ LINK ]

  96. F. Vadakkumpadan, H. Arevalo, A. Prassl, J. Chen, F. Kickinger, P. Kohl, G. Plank, N. Trayanova. Image-based models of cardiac structure in health and disease. Wiley Interdiscip Rev Syst Biol Med. 2(4): 489-506, 29 Jun 2010. [ LINK ]

  97. X. Jie, N. Trayanova. Mechanisms for initiation of reentry in acute regional ischemia phase 1B. Heart Rhythm. 7(3): 379-86, Mar 2010. [ LINK ]

  98. X. Jie, V. Gurev, N. Trayanova. Mechanisms of mechanically induced spontaneous arrhythmias in acute regional ischemia. Circ Res. 106(1): 185-92, 8 Jan 2010. [ LINK ]

  99. F. Vadakkumpadan, V. Gurev, J. Constantino, H. Arevalo, N. Trayanova. Modeling of whole-heart electrophysiology and mechanics: Towards patient-specific simulation. in: Patient Specific Modeling of the Cardiovascular System, pp 145-165. Ed. Roy C. P. Kerckhoffs, Springer Science+Business Media, 2010. [ LINK ]

  100. N. Trayanova. In the spotlight: cardiovascular engineering. IEEE Rev Biomed Eng. 3: 12-4, 2010. [ LINK ]

  101. N. Trayanova. In the Spotlight: Cardiovascular Engineering. IEEE Rev Biomed Eng. 2: 12, 17 Nov 2009. [ LINK ]

  102. M. Maleckar, J. Greenstein, W. Giles, N. Trayanova. Electrotonic coupling between human atrial myocytes and fibroblasts alters myocyte excitability and repolarization. Biophys J. 97(8): 2179-90, 21 Oct 2009. [ LINK ]

  103. M. Maleckar, J. Greenstein, W. Giles, N. Trayanova. K+ current changes account for the rate dependence of the action potential in the human atrial myocyte. Am J Physiol Heart Circ Physiol. 297(4): H1398-410, Oct 2009. [ LINK ]

  104. A. Prassl, F. Kickinger, H. Ahammer, V. Grau, J. Schneider, E. Hofer, E. Vigmond, N. Trayanova, G. Plank. Automatically generated, anatomically accurate meshes for cardiac electrophysiology problems. IEEE Trans Biomed Eng. 56(5): 1318-30, May 2009. [ LINK ]

  105. E. Vigmond, F. Vadakkumpadan, V. Gurev, H. Arevalo, M. Deo, G. Plank, N. Trayanova. Towards predictive modelling of the electrophysiology of the heart. Exp Physiol. 94(5): 563-77, May 2009. [ LINK ]

  106. F. Vadakkumpadan, L. Rantner, B. Tice, P. Boyle, A. Prassl, E. Vigmond, G. Plank, N. Trayanova. Image-based models of cardiac structure with applications in arrhythmia and defibrillation studies. J Electrocardiol. 42(2): 157.e1-10, 3 Feb 2009. [ LINK ]

  107. M. Maleckar, J. Greenstein, N. Trayanova, W. Giles. Mathematical simulations of ligand-gated and cell-type specific effects on the action potential of human atrium. Prog Biophys Mol Biol. 98(2-3): 161-70, 3 Feb 2009. [ LINK ]

  108. N. Trayanova, G. Plank. Bidomain Model of Defibrillation. in: Cardiac Bioelectric Therapy: Mechanisms and Practical Implications, pp 85-109. Eds. Efimov, Kroll, Tchou, Springer, 2009. [ LINK ]

  109. N. Trayanova, G. Plank. Modeling Cardiac Defibrillation. in: Cardiac Electrophysiology: From Cell to Bedside, pp 361-372. Eds. Zipes, Jalife, 5thEdition, W.B. Saunders Publishing Company, 2009.

  110. A. Akhbardeh, K. Tavakolian, V. Gurev, T. Lee, W. New, B. Kaminska, N. Trayanova. Comparative analysis of three different modalities for characterization of the seismocardiogram. Conf Proc IEEE Eng Med Biol Soc. 2009: 2899-903, 2009. [ LINK ]

  111. N. Trayanova, B. Tice. Integrative computational models of cardiac arrhythmias -- simulating the structurally realistic heart. Drug Discov Today Dis Models. 6(3): 85-91, 2009. [ LINK ]

  112. S. Narayan, J. Bayer, G. Lalani, N. Trayanova. Action potential dynamics explain arrhythmic vulnerability in human heart failure: a clinical and modeling study implicating abnormal calcium handling. J Am Coll Cardiol. 52(22): 1782-92, 25 Nov 2008. [ LINK ]

  113. M. Maleckar, M. Woods, V. Sidorov, M. Holcomb, D. Mashburn, J. Wikswo, N. Trayanova. Polarity reversal lowers activation time during diastolic field stimulation of the rabbit ventricles: insights into mechanisms. Am J Physiol Heart Circ Physiol. 295(4): H1626-33, Oct 2008. [ LINK ]

  114. G. Plank, L. Zhou, J. Greenstein, S. Cortassa, R. Winslow, B. O'Rourke, N. Trayanova. From mitochondrial ion channels to arrhythmias in the heart: computational techniques to bridge the spatio-temporal scales. Philos Trans A Math Phys Eng Sci. 366(1879): 3381-409, 28 Sep 2008. [ LINK ]

  115. Y. Rudy, M. Ackerman, D. Bers, C. Clancy, S. Houser, B. London, A. McCulloch, D. Przywara, R. Rasmusson, R. Solaro, N. Trayanova, D. Van Wagoner, A. Varró, J. Weiss, D. Lathrop. Systems approach to understanding electromechanical activity in the human heart: a national heart, lung, and blood institute workshop summary. Circulation. 118(11): 1202-11, 9 Sep 2008. [ LINK ]

  116. X. Jie, B. Rodríguez, J. de Groot, R. Coronel, N. Trayanova. Reentry in survived subepicardium coupled to depolarized and inexcitable midmyocardium: insights into arrhythmogenesis in ischemia phase 1B. Heart Rhythm. 5(7): 1036-44, Jul 2008. [ LINK ]

  117. N. Trayanova. The long and the short of long and short duration ventricular fibrillation. Circ Res. 102(10): 1151-2, 23 May 2008. [ LINK ]

  118. W. Li, V. Gurev, A. McCulloch, N. Trayanova. The role of mechanoelectric feedback in vulnerability to electric shock. Prog Biophys Mol Biol. 97(2-3): 461-78, 1 Apr 2008. [ LINK ]

  119. T. Ashihara, J. Constantino, N. Trayanova. Tunnel propagation of postshock activations as a hypothesis for fibrillation induction and isoelectric window. Circ Res. 102(6): 737-45, 28 Mar 2008. [ LINK ]

  120. G. Plank, A. Prassl, E. Hofer, N. Trayanova. Evaluating intramural virtual electrodes in the myocardial wedge preparation: simulations of experimental conditions. Biophys J. 94(5): 1904-15, 1 Mar 2008. [ LINK ]

  121. N. Trayanova. In the Spotlight: Cardiovascular Engineering. IEEE Rev Biomed Eng. 1: 12-4, 2008. [ LINK ]

  122. M. Bishop, B. Rodriguez, F. Qu, I. Efimov, D. Gavaghan, N. Trayanova. The role of photon scattering in optical signal distortion during arrhythmia and defibrillation. Biophys J. 93(10): 3714-26, 15 Nov 2007. [ LINK ]

  123. M. Bishop, D. Gavaghan, N. Trayanova, B. Rodriguez. Photon scattering effects in optical mapping of propagation and arrhythmogenesis in the heart. J Electrocardiol. 40(6 Suppl): S75-80, 13 Nov 2007. [ LINK ]

  124. B. Tice, B. Rodríguez, J. Eason, N. Trayanova. Mechanistic investigation into the arrhythmogenic role of transmural heterogeneities in regional ischaemia phase 1A. Europace. 9 Suppl 6: vi46-58, Nov 2007. [ LINK ]

  125. T. Maharaj, R. Blake, N. Trayanova, D. Gavaghan, B. Rodriguez. The role of transmural ventricular heterogeneities in cardiac vulnerability to electric shocks. Prog Biophys Mol Biol. 96(1-3): 321-38, 5 Oct 2007. [ LINK ]

  126. N. Estes III, R. Page, P. Boyden, R. Cappato, C. Chiu-Man, J. Day, J. DiMarco, A. Ferrick, M. Hamdan, R. Hamilton, S. Hohnloser, W. Jung, R. Kanter, B. Knight, B. Lindsay, A. Natale, D. Reynolds, D. Rosenbaum, L. Saxon, W. Shen, N. Trayanova, B. Wilkoff. Heart Rhythm Society Scientific Program Committee. Heart Rhythm. 4(10): e1-e9, Oct 2007.

  127. A. Komendantov, N. Trayanova, J. Tasker. Somato-dendritic mechanisms underlying the electrophysiological properties of hypothalamic magnocellular neuroendocrine cells: a multicompartmental model study. J Comput Neurosci. 23(2): 143-68, Oct 2007. [ LINK ]

  128. N. Trayanova. Drawing the curtain on the isoelectric window? Heart Rhythm. 4(6): 766-7, Jun 2007. [ LINK ]

  129. H. Arevalo, B. Rodriguez, N. Trayanova. Arrhythmogenesis in the heart: Multiscale modeling of the effects of defibrillation shocks and the role of electrophysiological heterogeneity. Chaos. 17(1): 015103, Mar 2007. [ LINK ]

  130. N. Trayanova, G. Plank. Arrhythmogenesis research: a perspective from computational electrophysiology viewpoint. Conf Proc IEEE Eng Med Biol Soc. 2007: 406-9, 2007. [ LINK ]

  131. M. Bishop, B. Rodriguez, N. Trayanova, D. Gavaghan. Inference of intramural wavefront orientation from optical recordings in realistic whole-heart models. Biophys J. 91(10): 3957-8, 15 Nov 2006. [ LINK ]

  132. N. Trayanova, G. Plank, B. Rodríguez. What have we learned from mathematical models of defibrillation and postshock arrhythmogenesis? Application of bidomain simulations. Heart Rhythm. 3(10): 1232-5, Oct 2006. [ LINK ]

  133. R. Burton, G. Plank, J. Schneider, V. Grau, H. Ahammer, S. Keeling, J. Lee, N. Smith, D. Gavaghan, N. Trayanova, P. Kohl. Three-dimensional models of individual cardiac histoanatomy: tools and challenges. Ann N Y Acad Sci. 1080: 301-19, Oct 2006. [ LINK ]

  134. V. Gurev, M. Maleckar, N. Trayanova. Cardiac defibrillation and the role of mechanoelectric feedback in postshock arrhythmogenesis. Ann N Y Acad Sci. 1080: 320-33, Oct 2006. [ LINK ]

  135. B. Rodríguez, N. Trayanova, D. Noble. Modeling cardiac ischemia. Ann N Y Acad Sci. 1080: 395-414, Oct 2006. [ LINK ]

  136. D. Bourn, M. Maleckar, B. Rodriguez, N. Trayanova. Mechanistic enquiry into the effect of increased pacing rate on the upper limit of vulnerability. Philos Trans A Math Phys Eng Sci. 364(1843): 1333-48, 15 Jun 2006. [ LINK ]

  137. S. Kuo, N. Trayanova. Action potential morphology heterogeneity in the atrium and its effect on atrial reentry: a two-dimensional and quasi-three-dimensional study. Philos Trans A Math Phys Eng Sci. 364(1843): 1349-66, 15 Jun 2006. [ LINK ]

  138. D. Bourn, R. Gray, N. Trayanova. Characterization of the relationship between preshock state and virtual electrode polarization-induced propagated graded responses resulting in arrhythmia induction. Heart Rhythm. 3(5): 583-95, May 2006. [ LINK ]

  139. M. Bishop, B. Rodriguez, J. Eason, J. Whiteley, N. Trayanova, D. Gavaghan. Synthesis of voltage-sensitive optical signals: application to panoramic optical mapping. Biophys J. 90(8): 2938-45, 15 Apr 2006. [ LINK ]

  140. N. Trayanova. Defibrillation of the heart: insights into mechanisms from modelling studies. Exp Physiol. 91(2): 323-37, Mar 2006. [ LINK ]

  141. W. Li, P. Kohl, N. Trayanova. Myocardial ischemia lowers precordial thump efficacy: an inquiry into mechanisms using three-dimensional simulations. Heart Rhythm. 3(2): 179-86, Feb 2006. [ LINK ]

  142. X. Jie, B. Rodriguez, N. Trayanova. Role of cellular uncoupling in arrhythmogenesis in ischemia phase 1B. Conf Proc IEEE Eng Med Biol Soc. 1: 2272-5, 2006. [ LINK ]

  143. M. Bishop, B. Rodriguez, N. Trayanova, D. Gavaghan. Modulation of shock-end virtual electrode polarisation as a direct result of 3D fluorescent photon scattering. Conf Proc IEEE Eng Med Biol Soc. 1: 1556-9, 2006. [ LINK ]

  144. B. Rodríguez, B. Tice, R. Blake, D. Gavaghan, N. Trayanova. Vulnerability to electric shocks in the regionally-ischemic ventricles. Conf Proc IEEE Eng Med Biol Soc. 1: 2280-3, 2006. [ LINK ]

  145. T. Maharaj, B. Rodriguez, R. Blake, N. Trayanova, D. Gavaghan. Transmural electrophysiological heterogeneities in action potential duration increase the upper limit of vulnerability. Conf Proc IEEE Eng Med Biol Soc. 1: 4043-6, 2006. [ LINK ]

  146. H. Arevalo, N. Trayanova. Maintenance of ventricular fibrillation in heterogeneous ventricle. Conf Proc IEEE Eng Med Biol Soc. 1: 3950-3, 2006. [ LINK ]

  147. T. Ashihara, N. Trayanova. Cell and tissue responses to electric shocks. Europace. 7 Suppl 2: 155-65, Sep 2005. [ LINK ]

  148. B. Rodríguez, J. Eason, N. Trayanova. Differences between left and right ventricular anatomy determine the types of reentrant circuits induced by an external electric shock. A rabbit heart simulation study. Prog Biophys Mol Biol. 90(1-3): 399-413, 2 Aug 2005. [ LINK ]

  149. B. Rodríguez, L. Li, J. Eason, I. Efimov, N. Trayanova. Differences between left and right ventricular chamber geometry affect cardiac vulnerability to electric shocks. Circ Res. 97(2): 168-75, 22 Jul 2005. [ LINK ]

  150. N. Trayanova. In pursuit of the elusive culprit. Heart Rhythm. 2(7): 729-30, Jul 2005. [ LINK ]

  151. X. Jie, B. Rodriguez, N. Trayanova. The ischemic heart: what causes ectopic beating? Conf Proc IEEE Eng Med Biol Soc. 7: 7194-7, 2005. [ LINK ]

  152. N. Trayanova. Cell and tissue responses to electric shocks invited paper. Conf Proc IEEE Eng Med Biol Soc. 7: 7216, 2005. [ LINK ]

  153. B. Rodríguez, B. Tice, J. Eason, F. Aguel, N. Trayanova. Cardiac vulnerability to electric shocks during phase 1A of acute global ischemia. Heart Rhythm. 1(6): 695-703, Dec 2004. [ LINK ]

  154. T. Ashihara, N. Trayanova. Asymmetry in membrane responses to electric shocks: insights from bidomain simulations. Biophys J. 87(4): 2271-82, Oct 2004. [ LINK ]

  155. W. Li, P. Kohl, N. Trayanova. Induction of ventricular arrhythmias following mechanical impact: a simulation study in 3D. J Mol Histol. 35(7): 679-86, Sep 2004. [ LINK ]

  156. E. Vigmond, V. Tsoi, S. Kuo, H. Arevalo, J. Kneller, S. Nattel, N. Trayanova. The effect of vagally induced dispersion of action potential duration on atrial arrhythmogenesis. Heart Rhythm. 1(3): 334-44, Sep 2004. [ LINK ]

  157. B. Rodríguez, B. Tice, J. Eason, F. Aguel, J. Ferrero, N. Trayanova. Effect of acute global ischemia on the upper limit of vulnerability: a simulation study. Am J Physiol Heart Circ Physiol. 286(6): H2078-88, Jun 2004. [ LINK ]

  158. N. Trayanova, W. Li, J. Eason, P. Kohl. Effect of stretch-activated channels on defibrillation efficacy. Heart Rhythm. 1(1): 67-77, May 2004. [ LINK ]

  159. N. Trayanova, F. Aguel, C. Larson, C. Haro. Modeling cardiac defibrillation: An inquiry into post-shock dynamics. in: Cardiac Electrophysiology: From Cell to Bedside, pp 282-290. Eds. Zipes, Jalife, 4thEdition, Saunders, 4 2004.

  160. M. Hillebrenner, J. Eason, N. Trayanova. Mechanistic inquiry into decrease in probability of defibrillation success with increase in complexity of preshock reentrant activity. Am J Physiol Heart Circ Physiol. 286(3): H909-17, Mar 2004. [ LINK ]

  161. T. Ashihara, T. Namba, T. Ikeda, M. Ito, K. Nakazawa, N. Trayanova. Mechanisms of myocardial capture and temporal excitable gap during spiral wave reentry in a bidomain model. Circulation. 109(7): 920-5, 24 Feb 2004. [ LINK ]

  162. T. Ashihara, T. Namba, M. Ito, T. Ikeda, K. Nakazawa, N. Trayanova. Spiral wave control by a localized stimulus: a bidomain model study. J Cardiovasc Electrophysiol. 15(2): 226-33, Feb 2004. [ LINK ]

  163. M. Hillebrenner, J. Eason, C. Campbell, N. Trayanova. Postshock arrhythmogenesis in a slice of the canine heart. J Cardiovasc Electrophysiol. 14(10 Suppl): S249-56, Oct 2003. [ LINK ]

  164. C. Larson, L. Dragnev, N. Trayanova. Analysis of electrically induced reentrant circuits in a sheet of myocardium. Ann Biomed Eng. 31(7): 768-80, 16 Sep 2003. [ LINK ]

  165. N. Trayanova, R. Gray, D. Bourn, J. Eason. Virtual electrode-induced positive and negative graded responses: new insights into fibrillation induction and defibrillation. J Cardiovasc Electrophysiol. 14(7): 756-63, Jul 2003. [ LINK ]

  166. J. Eason, N. Trayanova. The criterion for ventricular defibrillation: An error or not (Reply to the Editor). J. Cardiovasc. Electrophys. 14: 556-557, May 2003.

  167. E. Atkinson, N. Trayanova. Contact probes for MAP recording: A computational study. Journal of Biological Systems. 11: 139-160, 11 Jan 2003.

  168. F. Aguel, J. Eason, N. Trayanova. Advances in modeling cardiac defibrillation. Int. J. Bifurcations & Chaos. 13(12): 3791-3805, 2003.

  169. B. Rodríguez, N. Trayanova. Upper limit of vulnerability in a defibrillation model of the rabbit ventricles. J Electrocardiol. 36 Suppl: 51-6, 2003. [ LINK ]

  170. J. Meunier, J. Eason, N. Trayanova. Termination of reentry by a long-lasting AC shock in a slice of canine heart: a computational study. J Cardiovasc Electrophysiol. 13(12): 1253-61, Dec 2002. [ LINK ]

  171. E. Vigmond, F. Aguel, N. Trayanova. Computational techniques for solving the bidomain equations in three dimensions. IEEE Trans Biomed Eng. 49(11): 1260-9, Nov 2002. [ LINK ]

  172. N. Trayanova. Are we closer to understanding defibrillation in the whole heart? J Cardiovasc Electrophysiol. 13(11): 1128-30, Nov 2002. [ LINK ]

  173. N. Trayanova, J. Eason, F. Aguel. Computer simulations of cardiac defibrillation: a look inside the heart. Comput Visual Sci. 4: 259-270, 17 Sep 2002.

  174. N. Trayanova, J. Eason. Shock-induced arrhythmogenesis in the myocardium. Chaos. 12(3): 962-972, Sep 2002. [ LINK ]

  175. J. Eason, N. Trayanova. Phase singularities and termination of spiral wave reentry. J Cardiovasc Electrophysiol. 13(7): 672-9, Jul 2002. [ LINK ]

  176. K. Skouibine, J. Wall, W. Krassowska, N. Trayanova. Modelling induction of a rotor in cardiac muscle by perpendicular electric shocks. Med Biol Eng Comput. 40(1): 47-55, Jan 2002. [ LINK ]

  177. N. Trayanova, J. Eason, C. Anderson, F. Aguel. Computer modeling of defibrillation II: Why does the shock fail?. in: Quantitative Cardiac Electrophysiology, pp 235-256. Eds. C. Cabo, D. Rosenbaum, Marcel Dekker, New York, NY, 2002. [ LINK ]

  178. J. Wall, K. Skouibine, W. Krassowska, N. Trayanova. Induction of a rotor by cross-field stimulation: A modeling study with a realistic S2 shock. Med & Biol Eng & Comput. 40: 47-55, 2002.

  179. C. Anderson, N. Trayanova. Success and failure of biphasic shocks: results of bidomain simulations. Math Biosci. 174(2): 91-109, Dec 2001. [ LINK ]

  180. R. Gray, D. Huelsing, F. Aguel, N. Trayanova. Effect of strength and timing of transmembrane current pulses on isolated ventricular myocytes. J Cardiovasc Electrophysiol. 12(10): 1129-37, Oct 2001. [ LINK ]

  181. E. Vigmond, N. Trayanova, R. Malkin. Excitation of a cardiac muscle fiber by extracellularly applied sinusoidal current. J Cardiovasc Electrophysiol. 12(10): 1145-53, Oct 2001. [ LINK ]

  182. J. Meunier, N. Trayanova, R. Gray. Entrainment by an extracellular AC stimulus in a computational model of cardiac tissue. J Cardiovasc Electrophysiol. 12(10): 1176-84, Oct 2001. [ LINK ]

  183. E. Vigmond, R. Ruckdeschel, N. Trayanova. Reentry in a morphologically realistic atrial model. J Cardiovasc Electrophysiol. 12(9): 1046-54, Sep 2001. [ LINK ]

  184. A. Lindblom, F. Aguel, N. Trayanova. Virtual electrode polarization leads to reentry in the far field. J Cardiovasc Electrophysiol. 12(8): 946-56, Aug 2001. [ LINK ]

  185. N. Trayanova. Concepts of ventricular defibrillation. Philosophical Trans. Royal Society London. 359: 1327-1337, 15 Jun 2001.

  186. E. Azene, N. Trayanova, E. Warman. Wave front-obstacle interactions in cardiac tissue: a computational study. Ann Biomed Eng. 29(1): 35-46, Jan 2001. [ LINK ]

  187. N. Trayanova. Induction of reentry and defibrillation: The role of virtual electrodes. in: Computer Simulation and Experimental Assessment of Cardiac Function, pp 165-172. Eds. Virag, Blanc, Kappenberger, Futura Publishing Co, 2001. [ LINK ]

  188. C. Anderson, N. Trayanova, K. Skouibine. Termination of spiral waves with biphasic shocks: role of virtual electrode polarization. J Cardiovasc Electrophysiol. 11(12): 1386-96, Dec 2000. [ LINK ]

  189. I. Efimov, F. Aguel, Y. Cheng, B. Wollenzier, N. Trayanova. Virtual electrode polarization in the far field: implications for external defibrillation. Am J Physiol Heart Circ Physiol. 279(3): H1055-70, Sep 2000. [ LINK ]

  190. K. Skouibine, N. Trayanova, P. Moore. A numerically efficient model for simulation of defibrillation in an active bidomain sheet of myocardium. Math Biosci. 166(1): 85-100, Jul 2000. [ LINK ]

  191. K. Skouibine, N. Trayanova, P. Moore. Success and failure of the defibrillation shock: insights from a simulation study. J Cardiovasc Electrophysiol. 11(7): 785-96, Jul 2000. [ LINK ]

  192. A. Lindblom, B. Roth, N. Trayanova. Role of virtual electrodes in arrhythmogenesis: pinwheel experiment revisited. J Cardiovasc Electrophysiol. 11(3): 274-85, Mar 2000. [ LINK ]

  193. J. Meunier, N. Trayanova, R. Gray. Sinusoidal stimulation of myocardial tissue: effects on single cells. J Cardiovasc Electrophysiol. 10(12): 1619-30, Dec 1999. [ LINK ]

  194. S. Knisley, N. Trayanova, F. Aguel. Roles of electric field and fiber structure in cardiac electric stimulation. Biophys J. 77(3): 1404-17, Sep 1999. [ LINK ]

  195. K. Skouibine, N. Trayanova, P. Moore. Anode/cathode make and break phenomena in a model of defibrillation. IEEE Trans Biomed Eng. 46(7): 769-77, Jul 1999. [ LINK ]

  196. F. Aguel, K. Debruin, W. Krassowska, N. Trayanova. Effects of electroporation on the transmembrane potential distribution in a two-dimensional bidomain model of cardiac tissue. J Cardiovasc Electrophysiol. 10(5): 701-14, May 1999. [ LINK ]

  197. N. Trayanova. Far-field stimulation of cardiac tissue. Herzschrittmacher-Therapie & Electrophysiologie. 10: 137-148, Apr 1999.

  198. E. Entcheva, N. Trayanova, F. Claydon. Patterns of and mechanisms for shock-induced polarization in the heart: a bidomain analysis. IEEE Trans Biomed Eng. 46(3): 260-70, Mar 1999. [ LINK ]

  199. F. Aguel, J. Eason, N. Trayanova, G. Siekas, M. Fishler. Impact of transvenous lead position on active-can ICD defibrillation: a computer simulation study. Pacing Clin Electrophysiol. 22(1 Pt 2): 158-64, Jan 1999. [ LINK ]

  200. N. Trayanova, L. Malden, E. Atkinson. Computer model of MAP genesis. in: Monophasic Action Potentials, pp 47-69. Ed. M. Franz, 1999.

  201. N. Trayanova, F. Aguel, K. Skouibine. Extension of refractoriness in a model of cardiac defibrillation. Pac Symp Biocomput. 240-511999. [ LINK ]

  202. J. Eason, J. Schmidt, A. Dabasinskas, G. Siekas, F. Aguel, N. Trayanova. Influence of anisotropy on local and global measures of potential gradient in computer models of defibrillation. Ann Biomed Eng. 26(5): 840-9, 21 Oct 1998. [ LINK ]

  203. N. Trayanova, K. Skouibine, F. Aguel. The role of cardiac tissue structure in defibrillation. Chaos. 8(1): 221-233, Mar 1998. [ LINK ]

  204. N. Trayanova, K. Skouibine, P. Moore. Virtual electrode effects in defibrillation. Prog Biophys Mol Biol. 69(2-3): 387-403, 1998. [ LINK ]

  205. N. Trayanova, K. Skouibine. Modeling defibrillation: effects of fiber curvature. J Electrocardiol. 31 Suppl: 23-9, 1998. [ LINK ]

  206. N. Trayanova. Effects of the tissue-bath interface on the induced transmembrane potential: a modeling study in cardiac stimulation. Ann Biomed Eng. 25(5): 783-92, 23 Sep 1997. [ LINK ]

  207. N. Trayanova, M. Bray. Membrane refractoriness and excitation induced in cardiac fibers by monophasic and biphasic shocks. J Cardiovasc Electrophysiol. 8(7): 745-57, Jul 1997. [ LINK ]

  208. N. Trayanova. Cardiac stimulation in the presence of a conducting medium: Results from a modeling study. Annals Biomed. Eng. 25: 783-792, 1997.

  209. N. Trayanova. Discrete versus syncytial tissue behavior in a model of cardiac stimulation--I: Mathematical formulation. IEEE Trans Biomed Eng. 43(12): 1129-40, Dec 1996. [ LINK ]

  210. N. Trayanova. Discrete versus syncytial tissue behavior in a model of cardiac stimulation--II: Results of simulation. IEEE Trans Biomed Eng. 43(12): 1141-50, Dec 1996. [ LINK ]

  211. N. Trayanova. A bidomain model for ring stimulation of a cardiac strand. IEEE Trans Biomed Eng. 41(4): 393-7, Apr 1994. [ LINK ]

  212. N. Trayanova. An approximate solution to the periodic bidomain equations in one dimension. Math Biosci. 120(2): 189-210, Apr 1994. [ LINK ]

  213. N. Trayanova, B. Roth, L. Malden. The response of a spherical heart to a uniform electric field: a bidomain analysis of cardiac stimulation. IEEE Trans Biomed Eng. 40(9): 899-908, Sep 1993. [ LINK ]

  214. N. Trayanova, T. Pilkington. A bidomain model with periodic intracellular junctions: a one-dimensional analysis. IEEE Trans Biomed Eng. 40(5): 424-33, May 1993. [ LINK ]

  215. R. Enoka, N. Trayanova, Y. Laouris, L. Bevan, R. Reinking, D. Stuart. Fatigue-related changes in motor unit action potentials of adult cats. Muscle Nerve. 15(2): 138-50, Feb 1992. [ LINK ]

  216. N. Trayanova, T. Pilkington. The use of spectral methods in bidomain studies. Crit Rev Biomed Eng. 20(3-4): 255-77, 1992. [ LINK ]

  217. N. Trayanova, C. Henriquez. Examination of the choice of models for computing the extracellular potential of a single fibre in a restricted volume conductor. Med Biol Eng Comput. 29(6): 580-4, Nov 1991. [ LINK ]

  218. N. Trayanova, C. Henriquez. Modification of a cylindrical bidomain model for cardiac tissue. Math Biosci. 104(1): 59-72, Apr 1991. [ LINK ]

  219. D. Popivanov, T. Gavrilenko, G. Gantchev, N. Trayanova. Spatio-temporal characteristics of SEP to tibial nerve stimulation. Acta Physiol Pharmacol Bulg. 17(2-3): 32-9, 1991. [ LINK ]

  220. T. Genchev, T. Yanev, A. Gydikov, N. Trayanova. Location of the motor unit electrical axis and determination of the muscle anisotropy ratio. Biol. Cybern. 63: 229-236, 31 Jan 1990.

  221. N. Trayanova. Electrical behavior of a skeletal muscle fiber in a volume conductor of finite extent. Biol. Cybern. 63: 121-125, 25 Jan 1990.

  222. N. Trayanova, C. Henriquez, R. Plonsey. Limitations of approximate solutions for computing the extracellular potential of single fibers and bundle equivalents. IEEE Trans Biomed Eng. 37(1): 22-35, Jan 1990. [ LINK ]

  223. A. Gydikov, A. Kossev, N. Trayanova, D. Stephanova. Electrotonic potentials of myelinated nerve fibers. Electromyogr Clin Neurophysiol. 30(1): 47-51, Jan 1990. [ LINK ]

  224. A. Gydikov, N. Trayanova. A volume conductor study of electrotonic potentials of unmyelinated excitable fibers. Electromyogr. Clin. Neurophysiol. 30: 227-231, 1990.

  225. C. Henriquez, N. Trayanova, R. Plonsey. A planar slab bidomain model for cardiac tissue. Ann Biomed Eng. 18(4): 367-76, 1990. [ LINK ]

  226. N. Trayanova, C. Henriquez, R. Plonsey. Extracellular potentials and currents of a single active fiber in a restricted volume conductor. Ann Biomed Eng. 18(3): 219-38, 1990. [ LINK ]

  227. N. Trayanova. Equivalent sources for the extracellular potentials of single fibers and bundles. Acta Physiol Pharmacol Bulg. 16(1): 3-7, 1990. [ LINK ]

  228. N. Trayanova. Separation of the sodium and potassium currents from an action potential of a single active fiber. Acta Physiol Pharmacol Bulg. 15(4): 53-8, 1989. [ LINK ]

  229. D. Stephanova, N. Trayanova, A. Gydikov, A. Kossev. Extracellular potentials of a single myelinated nerve fiber in an unbounded volume conductor. Biol Cybern. 61(3): 205-10, 1989. [ LINK ]

  230. A. Kossev, A. Gydikov, N. Trayanova, D. Kosarov. Configuration and selectivity of the branched EMG-electrodes. Electromyogr Clin Neurophysiol. 28(7-8): 397-403, 1 Nov 1988. [ LINK ]

  231. C. Henriquez, N. Trayanova, R. Plonsey. Potential and current distributions in a cylindrical bundle of cardiac tissue. Biophys J. 53(6): 907-18, Jun 1988. [ LINK ]

  232. R. Plonsey, C. Henriquez, N. Trayanova. Extracellular (volume conductor) effect on adjoining cardiac muscle electrophysiology. Med Biol Eng Comput. 26(2): 126-9, Mar 1988. [ LINK ]

  233. A. Kossev, A. Gydikov, N. Trayanova. Comparison of the different variants of the current source density analysis methods in neurophysiological studies. Acta Physiol Pharmacol Bulg. 14(2): 75-82, 1988. [ LINK ]

  234. N. Trayanova. A method for calculation the extracellular potentials from experimentally recorded intracellular potentials of a single muscle fibers. Acta Physiol Pharmacol Bulg. 14(2): 83-91, 1988. [ LINK ]

  235. N. Trayanova, A. Gydikov. Extracellular potential field caused by the resting potential of a myelinated nerve fibre. Electromyogr Clin Neurophysiol. 27(4): 203-7, 1 Jun 1987. [ LINK ]

  236. N. Radicheva, N. Trayanova, A. Gydikov, L. Gerilovsky. Extracellular potential field of unmyelinated active axons. Acta Physiol Pharmacol Bulg. 13(2): 22-9, 1987. [ LINK ]

  237. N. Trayanova, A. Gydikov, A. Kossev. Optimization of the source derivations from the scalp surface. Acta Physiol Pharmacol Bulg. 13(2): 60-8, 1987. [ LINK ]

  238. N. Trayanova, A. Gydikov. Some features of the extracellular potential field of active single muscle fibres. A model investigation. Electromyogr Clin Neurophysiol. 26(7): 612-22, 1 Oct 1986. [ LINK ]

  239. A. Gydikov, A. Kossev, N. Trayanova, N. Radicheva. Selective recording of motor unit potentials. Electromyogr Clin Neurophysiol. 26(4): 273-81, 1 Jun 1986. [ LINK ]

  240. A. Gydikov, N. Trayanova. Extracellular potentials of single active muscle fibres: effects of finite fibre length. Biol Cybern. 53(6): 363-72, 1986. [ LINK ]

  241. A. Gydikov, L. Gerilovsky, N. Radicheva, N. Trayanova. Influence of the muscle fibre end geometry on the extracellular potentials. Biol Cybern. 54(1): 1-8, 1986. [ LINK ]

  242. A. Gydikov, D. Kosarov, A. Kossev, K. Kostov, N. Trayanova, N. Radicheva. Motor unit potentials at high muscle activity recorded by selective electrodes. Biomed Biochim Acta. 45(1-2): S63-8, 1986. [ LINK ]

  243. N. Trayanova. Influence of the fibre end on the calculated extracellular potentials of single muscle fibres. Electromyogr Clin Neurophysiol. 25(6): 443-51, 1 Sep 1985. [ LINK ]

  244. A. Gydikov, L. Gerilovski, N. Radicheva, N. Trayanova. Relations between the shapes of different muscle potentials. Experimental and model investigations. Acta Physiol Pharmacol Bulg. 11(4): 33-41, 1985. [ LINK ]

  245. N. Trayanova, G. Dimitrov. Mathematical models of the extracellular potentials generated by excitable fibres in a volume conductor. Electromyogr Clin Neurophysiol. 23(1-2): 123-37, 1 Jan 1983. [ LINK ]

  246. N. Trayanova. Influence of the changes in the velocity of spreading of the action potential on the distribution of the level of depolarization along an excitable fibre. Electromyogr Clin Neurophysiol. 23(1-2): 61-71, 1 Jan 1983. [ LINK ]

  247. N. Trayanova, G. Dimitrov. Extracellular potentials in the proximity of the excitable fibres. Electromyogr Clin Neurophysiol. 22(4): 291-301, 1 May 1982. [ LINK ]