Introduction to PET quantification
Class 1
Measurements in quantitative dynamic PET
Tracer time activity in plasma as input function
Metabolite correction
Calibration
Tracer tissue kinetics measured by dynamic PET as output
PET physics and quality control
data collection
data correction
Class 2
Compartment model with plasma input function
Definition of compartmental model
One-tissue compartment model
[15]O water PET
Two-tissue compartment model: parallel and sequential configuration
FDG
[68Ga]-EDTA tumor kinetics
[11C]raclopride
Compartment models of reversible and irreversible kinetics
Reversible
Irreversible
Macro- versus micro-parameters
K1
Distribution volume
Ki
Binding potential (BPND)
Linear and nonlinear compartmental model for ligand-receptor binding
In vivo versus in vitro BPND measurements
Receptor occupancy
Class 3
Graphical analysis with plasma input function
Gjedde-Patlak plot
Logan plot
Relative equilibrium-based graphical plot (RE plot)
Multi-graphical analysis
Class 4
Spectral analysis of tissue kinetics
Spectral analysis versus compartmental model
Determination of spectral range
Class 5
Reference tissue model (RTM)
One-tissue compartment model based RTM
Two-tissue compartment model based RTM
Graphical analysis using reference tissue input
Class 6
Mathematical basis for kinetic modeling
Differential and integration operation
Matrix algebra
linear and nonlinear regression
Optimization algorithm
References
Project