Maryland Stem Cell Research Fund (TEDCO)

07/01/2009 to 06/30/12
Role: Principal Investigator
Title: Human Stem Cell Therapy after Early Hypothermia in Spinal Cord Injury: Anatomical and Functional Correlates of Recovery

The long term goal of the proposed research is to establish the utility of human embryonic stem (hES) cell therapy. We proposed to use early hypothermia followed by hES cell injections and monitor the progress of recovery using a comprehensive set of clinically accepted assessment methods, including imaging and electrophysiological assessments, and behavioral assessments. By combining these different assessment approaches, we will develop a complete picture of how hES cells integrate into the parenchyma of the spinal cord and improving both the functionality and the architecture of the neural pathways.


(PI: J. Bulte)
04/01/09 to 03/31/14
Role: Co-Investigator
Title: MR and BL Tracking of Stem/Progenitor Cells in the ALS

The goal is to use MRI and BLI to monitor the migration, host tissue integration, and survival of transplanted motor neuron precursors, and whether high integration and survival rates will correlate with the measured functional recovery and total skeletal muscle mass measurements.

Maryland Stem Cell Research Fund (TEDCO)

10/01/07 to 09/30/10
Role: Principal Investigator
Title: Human Embryonic Stem Cell-Derived Oligodendrocytes and Electrophysiological Studies in a Contusion Model of Spinal Cord Injury in the Rat

The main long-term goal is measuring and quantifying spinal cord injury and recovery following stem cell transplantation while concurrently applying advanced Sensory and Motor Evoked Potentials technologies and quantitative methods for monitoring and measuring the extent of injury, post-therapy recovery, as well as the integrity of the spinal cord itself.

Transverse Myelitis Research Project

(PI: D. Kerr)
12/12/07 to 01/31/10
Role: Investigator

RESTORE Fund: The Johns Hopkins Project RESTORE was established to develop new diagnostic and therapeutic strategies for the treatment of neuro-immunologic disorders, such as multiple sclerosis (MS) and transverse myelitis (TM). Project RESTORE has a tripartite mission: to enable patients to recover from acute attacks and illness; to stop progression of disease and disability; and to regenerate nerve cells and myelin.