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The newspaper of The Johns Hopkins University January 24, 2005 | Vol. 34 No. 19
Research Sheds Fresh Light on How Cancer Cells Become Resistant to Treatment

A new study by researchers at Memorial Sloan-Kettering Cancer Center and Johns Hopkins provides fresh insight into how tumor cells can become resistant to anticancer therapy.

The scientists observed that a protein called P-glycoprotein, which causes resistance to chemotherapy in many tumor types, is able to physically "jump" or transfer between tumor cells and retain its functional properties, protecting otherwise sensitive cells from the effects of anticancer treatment. According to the authors, the research is the first to demonstrate that a protein transferred between cells retains its function long enough to allow the recipient cells to survive potentially toxic drug concentrations and ultimately develop intrinsic resistance.

In other words, cells that would normally be sensitive to treatment can develop resistance to it by receiving P-glycoprotein from other cells, making chemotherapy much less efficient. Uncovering the mechanism of this unusual "jumping" of the protein between the cells can potentially improve treatment success. The authors conclude that their findings offer a new way in which to look at how cells behave in a community of cells within a tumor mass. The results have important implications for genomic analyses within tumor samples because resistance to cancer therapy can be achieved by protein transfer alone.

The new research was published last week in the online Early Edition of the Proceedings of the National Academy of Sciences.

The lead author was Andre Levchenko, formerly of Memorial Sloan-Kettering Cancer Center and currently assistant professor in the Department of Biomedical Engineering at Johns Hopkins. Levchenko is based at Clark Hall on the Homewood campus.

The work was supported by the Department of Energy, the Whitaker Foundation and Memorial Sloan-Kettering Cancer Center.


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