Covering New Ground

Josh Cogan is part of an
interdisciplinary team working on wireless sensor networks
for monitoring soil in various city sites. Behind him are
team members Razvan Masaloiu-E and Andreas Terzis and
Cogan's faculty sponsor, Katalin Szlavecz.
PHOTO BY HPIS/WILL KIRK
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PURA grants in hand, 42 undergrads explore the world of
research
In research, questions often outnumber answers and
it's anyone's guess where the journey will end, or how long
it will take to get there. This year's recipients of Provost's Undergraduate Research Awards
found this to be true as they peered into Shanghai's past,
investigated a mysterious figurine's origins, attempted to
design a long-term wireless soil monitoring system and
conducted various other projects.
On Thursday, March 16, Steven Knapp, university
provost and senior vice president for academic affairs,
will host the 13th annual PURA awards ceremony, which will
honor the 39 projects carried out by 42 students in the
summer and fall of 2005.
Since 1993, about 40 students each year have received
PURA grants of up to $3,000 to conduct original research,
some results of which have been published in professional
journals. The awards, funded through a donation from the
Hodson Trust, are an important part of the university's
mission and its commitment to research opportunities for
undergraduates.
The awards are open to students in each of the
university's four schools with full-time undergraduates:
the Krieger School of Arts and Sciences, the Whiting School
of Engineering, the Peabody Conservatory and the School of
Nursing.
The 2006 ceremony will be held in the Glass Pavilion
at Homewood. The entire Hopkins community is invited to the
event, which begins at 3 p.m. with an informal poster
session allowing students to display and talk about their
projects. A recognition ceremony hosted by Knapp will begin
at 4:30 p.m. and will include two presentations by PURA
recipient Andrew Arceci of Peabody. A reception follows at
approximately 5:15 p.m.
Whether students found solutions or just scraped the
surface of a larger puzzle, the journey to discovery
provided valuable lessons learned. A sampling of the
winners follows.

A vexing votive figure

Megan Goldman-Petri, foreground,
worked with Eunice Dauterman Maguire to try to identify an
artifact from the Johns Hopkins Archaeological Collection.
PHOTO BY HPIS/WILL KIRK
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PURA winner Megan Goldman-Petri asserts that
the best art historian is one who can tell you what a
particular artifact is — or isn't — in the
blink of an eye, based solely on the imaginary exhibition
catalog of all the pieces he or she has seen over the
years.
"The trick is to find the right person who has seen
something like it before so they can place it,"
Goldman-Petri says.
But some of the best minds' eyes in the business were
stumped when Goldman-Petri showed them a mysterious figure,
presumably a votive carving, from the Johns Hopkins
Archaeological Collection. From the British Museum to the
Freer Gallery in D.C., none of the renowned scholars
Goldman-Petri consulted could recall seeing anything quite
like the well-worn, 12-by-4-inch "tannish gray" figure at
the heart of her PURA project, "Cult Practice, Technology
and Science: A JHU Archaeological Collection Case Study."
"They all agree it's old, but how old, no one can
agree for sure," says Goldman-Petri, a junior from
Timonium, Md., who is double majoring in
History of Art
and Classics.
A materials analysis showed it's probably made from shale
or steatite, but scholars she consulted on its intangible
qualities told her mostly what the votive figure is not.
Pressed to hazard a guess herself, Goldman-Petri treads
lightly.
"As for what it is, my best guess is that it's
Spanish, Catalan or Egyptian," all locales that were
subjected to Christian influences at some point,
Goldman-Petri says. Linguists can't read the inscription as
either standard Greek or Coptic. "And I'm also told that
it's not a 'magical' inscription."
She takes a stronger stance when it comes to the
figure's provenance. Goldman-Petri believes it is part of a
large contribution of artifacts made to the Hopkins
collection by Harry Langford Wilson, a JHU professor of
classics, in the early 20th century. Wilson, like
Goldman-Petri, had an affinity for normative artifacts, or
items used by regular people for everyday tasks or for
marking the burials of their dead. Goldman-Petri believes
her PURA project figure falls into this category.
"It's not something that was used for a state-dictated
purpose," Goldman-Petri says. "Studying these kinds of
pieces gives you the opportunity to think like an everyday
person using them would have. They allow you to put
yourself in their shoes and really see the world and what
it was like for them."
Her quest to place the figure was sparked by a fall
2004 course titled Creating a Museum Exhibition with her
future PURA adviser, Eunice Dauterman Maguire, curator of
the Johns Hopkins Archaeological Collection and a senior
lecturer in the History of Art Department. Maguire has
researched and published art historical material related to
the Christian period in Egypt and was able to introduce
Goldman-Petri to other specialists as well. All told,
eight members of the JHU faculty in four departments
examined the carving to give their opinions, along with
graduate students from several departments and specialists
from a number of museums.
"Her project is an excellent example of the role of
the Archaeological Collection in providing unique and
unplowed territory for student research," Maguire says.
The open-ended nature of her PURA project is, in its
own way, a blessing. Even though her PURA was technically
undertaken during fall 2005, Goldman-Petri is still on the
case, having made it the subject of an independent study
project. And her honors thesis for her Classics degree is
also an extension of her PURA work — she's studying
votives.
"It's a study for life because I'll probably be
thinking of it forever," she says. "And then one day, I'll
open a book and see it in there and say, 'Oh, that's what
it is.'"
— Amy Lunday

Old Shanghai in posters

Back from Shanghai, Warner Brown
does further study on 'yuefenpai.' He'll present his
findings next month at the Association for Asian Studies'
annual meeting.
PHOTO BY HPIS/WILL KIRK
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Warner Brown's PURA project took him across the globe
to Shanghai, China. Brown, a senior
history major
from Shreveport, La., went to the storied city to delve
into the world of early-20th-century commercial art.
Specifically, Brown focused on yuefenpai (calendar
posters), a popular form of advertisement in the 1920s and
1930s. Contemporary Shanghainese have been gripped with a
nostalgia for the period, in particular its popular art.
Brown wanted to look into what was fueling this interest
and how the appeal of yuefenpai relates to the question of
Shanghai's search for cultural identity.
The posters, produced for both domestic and foreign
companies, typically featured a depiction of a "modern"
Chinese woman wearing a qipao, a body-hugging dress with a
high cut. Distributed as premiums with the purchase of
products, the posters contained the company's name,
sometimes a calendar and often images of that company's
goods, such as toiletries and cigarettes. Shanghai at the
time was the metropolis of all Asia and a melting pot of
Western influences, a reality borne out in the images.
Brown says the posters had a sort of pin-up quality,
as they invariably featured images of attractive young
women, including popular actresses and other celebrities.
He says the intention was to represent an ideal rather than
the typical woman of the period. For example, some posters
featured women posed in luxurious apartments or playing
golf.
"Few women back then could actually achieve this level
of wealth and glamour. Life for the average citizen wasn't
really like it was depicted in the posters," he says. "[The
images] were something you could put on the wall and dream
about."
Production of yuefenpai slowed in 1937 at the onset of
the second Sino-Japanese War, when Japan invaded China.
When communists took over China in 1949, many of the
posters were destroyed as they represented capitalism and
Western decadence.
Today, the posters are a favorite of collectors, and
originals can fetch $5,000 or more at auctions.
Brown began his research journey at the library for
the Freer and Sackler galleries in Washington, D.C., and
last summer spent eight weeks in Shanghai, where he spoke
with collectors, historians and city residents. Brown's
interest in the Chinese city is rooted in the opening
scene, set in a Shanghai nightclub, of the movie Indiana
Jones and the Temple of Doom, a childhood favorite.
Shanghai in the past 15 years has witnessed a cultural
and economic rebirth, Brown says, and citizens have by and
large embraced its cosmopolitan past. Several of the
restaurants Brown visited in Shanghai prominently displayed
the posters, in addition to other period artifacts. "The
posters are not single-handedly driving nostalgia, but they
are a very big part of it," he says.
Brown says that the posters provided an insightful
lens through which to view the period in which they were
made, and concurrently why people want to identify with
that past.
He will present his findings at the Association for
Asian Studies' annual meeting, to held next month in San
Francisco. Tobie Meyer-Fong, an assistant professor of
history and Brown's faculty sponsor, says it is exceedingly
rare for an undergraduate to be given such an honor.
"Warner has had the inspired idea of considering
Shanghai commercial art from the 1920s and '30s as part of
the formation of a new, cosmopolitan urban identity,"
Meyer-Fong says. "Others have mined these images for what
they can tell us about gender during this period — or
the production of a visual culture of modernity or
consumerism — but to my knowledge only Warner has
considered them for what they can tell us about both the
past, when they were created, and the present."
— Greg Rienzi

AIDS prevention in South Africa

Claire Edington spent last summer
in sub-Saharan South Africa looking at measures to prevent
the spread of HIV-AIDS among women in the
region.
PHOTO BY HPIS/WILL KIRK
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Claire Edington, a senior from Wayland, Mass.,
traveled to sub-Saharan South Africa to participate in a
three-month clinical study on measures to prevent the
spread of HIV-AIDS among women in that region.
Last summer, she worked at the African Centre for
Health and Population Studies, which is located in the
remote township of Mtubatuba, in the Northeast Province of
KwaZulu Natal. Funded by the UK Department for
International Development, the site is one of six aimed at
developing safe and effective vaginal gels that would allow
women to protect themselves from the HIV virus in a social,
political and economic system that makes it difficult to
ask men to wear condoms, according to Edington.
"It's a very complex situation in which women feel
that they are at high risk for HIV, but they also feel that
they don't have much control in demanding that their
partners use condoms," she says. "Prevention strategies
aimed exclusively at condom use just can't work when women
are not in the position to refuse risky sex. That's why
it's crucial that we develop a strategy that takes into
account the reality of these women's lives."
During her summer research, Edington asked Zulu women
to keep "coital diaries": accounts, often pictorial, of
sexual activity, including data about frequency and types
of sexual intercourse (vaginal or anal), condom use and
type of partner (regular or casual). She ended up reviewing
more than 200 of these diaries and linking that information
with data about the women's HIV knowledge, awareness and
perception of risk.
Her research revealed that 96 percent of women knew
that HIV could be acquired through sex with a person
infected with that virus, and that 94 percent of women
worried that they were at risk for contracting HIV.
"Women felt at risk for two major reasons: 82.42
percent because they do not use condoms, and 82.32 percent
because of an unfaithful partner," she explains. "Yet only
53 percent of women reported ever having used a condom, and
78 percent said that they don't use condoms because their
partner did not want to use them. My findings indicate that
women feel that they are at high risk for HIV but don't
have much control in terms of trying to prevent it by
demanding their partners use condoms."
Edington believes that her research findings support
the importance of developing a microbicidal gel that women
could use to protect themselves from HIV in a setting where
the power structure does not allow them to refuse to engage
in risky sexual encounters. Furthermore, the fact that
HIV/AIDS is highly stigmatized within this community means
that there is little to no discussion on how women might
protect themselves.
"With one of three people in the area estimated to be
HIV-positive, microbicides have become an increasingly
promising alternative to prevention strategies, such as ABC
[Abstain, Be Faithful, Use Condoms], by giving women
control over their own bodies," Edington says. "Women have
demonstrated a clear interest in using methods, like
microbicides, that protect them from the consequences of
high-risk sexual behavior that they often are unable to
control."
Goodyear praises Edington and her work.
"Ms. Edington's PURA proposal was a focused outgrowth
of her public health studies major," he says. "The major is
currently the second largest in Arts and Sciences. One of
the great things about the major is [that] the diversity of
courses attracts the intellectually curious like Claire. As
an incoming freshman, Claire had no idea that she would
major in public health studies, but her commitment to
social justice, and the opportunity to take courses at the
School of Public
Health, drew her in. She has truly made the major work
for her, and the world of public health has engaged a
rising star."
— Lisa De Nike

Painful echoes of abuse

Nursing student Corrie Ann McKeen,
here with sponsor Nancy Woods, wanted to understand why
abused women can suffer long-term pain, fatigue and
depression.
PHOTO BY HPIS/WILL KIRK
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Corrie Ann McKeen holds more than a theoretical
interest in her studies at the
School of Nursing.
As a survivor of abuse and subsequent fibromyalgia, a
disorder characterized by muscle pain and fatigue, McKeen
was fascinated to learn that victims of intimate partner
violence often experience the long-term symptoms of pain,
fatigue and depression.
"I had to learn more," McKeen says. "Of course my
personal history sparked intellectual curiosity, but my
volunteer work at the Family StressLine, a Baltimore-based
crisis hotline, also showed me the importance of helping
victims of violence."
Under the guidance of faculty member Nancy Woods, and
in collaboration with Professor Gayle Page, McKeen built
upon the work of previous nurse researchers who
investigated the relationship between abuse and the
multiple, vague physical and mental health symptoms often
presented by abused women. McKeen's research focused on
understanding the biological mechanism that causes the
"sickness behavior symptoms" of pain, fatigue and
depression.
A previous study by Woods had shown that abused women
have higher levels of inflammatory cytokines, the
"messengers" used by white blood cells to communicate with
one another that can induce profound psychological and
behavioral changes. Funded by PURA, McKeen set out to
discover whether the symptoms of pain, fatigue and
depression could be attributed to the increased number of
inflammatory cytokines in abused women.
McKeen used detailed interview data and blood samples
that had been collected from more than 100 women at a
primary care clinic for the uninsured in Baltimore. About
half the sample had a history of intimate partner violence.
After analyzing blood samples for inflammatory cytokines,
McKeen was able to test her hypothesis.
She determined that women with a history of intimate
partner violence reported a greater prevalence of the
"sickness behavior symptoms" of pain, fatigue and
depression, and that the women with these symptoms did
indeed have higher levels of inflammatory cytokines,
specifically tumor necrosis factor. Says McKeen, "Ours was
the first study to uncover this biological mechanism
through which violence affects physical and mental
health."
In June, McKeen and Woods will present their findings
at the Association of Women's Health, Obstetric and
Neonatal Nurses 2006 Convention. And over the remainder of
the spring semester, the two will be working on a
manuscript to submit for publication.
According to McKeen, the PURA-funded project "helped
bring research out of the pages of my textbooks and into
real life." The high level of quality expected of a Johns
Hopkins nurse researcher made an impression on McKeen, who
says her admiration for Woods and the other faculty at the
School of Nursing "has grown leaps and bounds" during the
course of the project.
To pursue her interest in pediatrics, women's health
and global health, McKeen is applying to Johns Hopkins'
MSN/MPH program, run jointly by the schools of Nursing and
Public Health. She hopes for a career in nursing
administration and plans to pursue further research on
fibromyalgia.
"When I first began this project, I was a little
intimidated by Dr. Woods' knowledge and expertise. She was
conducting such excellent and thorough research, while I
had to ask questions like 'What's a cytokine again?'" jokes
McKeen. "But I did learn that people can accomplish a lot
more than they ever thought possible, especially if they
have a wonderful mentor like Dr. Woods."
— Kelly Brooks-Staub

Wireless long-term soil monitoring

Josh Cogan
PHOTO BY HPIS/WILL KIRK
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A 19-year-old sophomore physics major, Joshua
Cogan is playing an important role in helping to
develop a wireless monitoring system that may eventually
assist earth scientists in developing a more detailed
understanding of various ecosystems.
His PURA research focused on whether an inexpensive,
commercially available sensor called the Watermark is
suitable for long-term soil monitoring use.
Cogan, who is from Wayne, Pa., got involved in this
earth science-centered research after taking an ecology
course with Katalin Szlavecz, a senior lecturer in the
Department of Earth and
Planetary Sciences, during his freshman year. Impressed
with Cogan's intelligence and acumen, Szlavecz recruited
him to work with her.
"It was almost immediately apparent to me that Josh
would be an asset in my lab," says Szlavecz, who served as
Cogan's PURA adviser. "He is very smart, and I knew that
his background in physics and electronics would be an asset
in our research and problem solving."
Cogan joined an interdisciplinary team working on
wireless sensor networks. The ultimate goal of the project
is to develop a wireless soil monitoring system that can be
installed in various city sites, such as Leakin Park or Cub
Hill, as part of the Baltimore Ecosystem Project, a
long-term ecological research project focusing on urban
environments. In addition to Szlavecz, the team includes
Andreas Terzis, an assistant professor of
computer science in
the Whiting School of Engineering; computer science
students Razvan Musaloiu-E and Sam Small, from the Whiting
School; and Alex Szalay, a professor in the Krieger
School's Henry A. Rowland
Department of Physics
and Astronomy.
"Soil monitoring systems collect data about the
physical, chemical and biological attributes of soil in
situ and almost constantly," Cogan says. "Our goal is to
develop a system at a scale that currently does not exist.
Remote sensing networks allow us to collect data with
minimal human intrusion, which is very important because
whenever humans go to the field to collect data, they
inadvertently change the ecosystem they are measuring."
Cogan's role in the research involved assembling the
sensors, which consist of electrodes embedded in a granular
quartz material surrounded by a membrane and metal mesh,
with a wire sticking out of the end. Cogan then soldered
the wire to a sensor board that held other sensors to
measure air temperature, soil temperature and light
intensity. He then attached those boards to a remote with a
small antenna, which transmitted data about each sample to
the lab's computer.
Over the course of the project, the team learned that
the Watermarks sensors were not adequately precise in
measuring the data collected. They found that in order to
get the level of precision they wanted, they would need to
calibrate each sensor individually — a very
time-intensive process.
"One of the lessons we learned here is that the
Watermark sensor, though inexpensive, is not ideal for this
kind of long-term monitoring," Szlavecz says. "But what we
learned will also help us to improve our approach next
time, both in hardware and in software."
And Cogan learned valuable lessons not just about
earth science but also about interdisciplinary teamwork.
"You hear about interdisciplinary research all the
time, but no one tells you how hard it is to simply
communicate with all the different parties involved," he
reflects. "Our computer science members speak about
sampling and transmission. The physicists — including
me — talk about voltages and dielectric constants.
The soil ecologists had other concerns, such as how soil
invertebrate heterogeneity relates to physical factors in
the soil. Believe me: Communication was no trivial
concern!"
— Lisa De Nike

Finding a catalyst for cartilage
creation

Thanissara 'Noon' Chansakul,
foreground, is working with Jennifer Elisseeff to find the
right cells and proper medium to grow new cartilage to
repair injuries.
PHOTO BY HPIS/WILL KIRK
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Using adult and embryonic stem cells from mice,
Thanissara Chansakul is conducting important
experiments in a project aimed at growing new cartilage to
repair injured knees and other body parts. Chansakul, a
junior chemical and
biomolecular engineering major, is helping a research
team led by Jennifer Elisseeff find out whether mixing the
two types of stem cells with a particular growth medium
will cause the cells to thrive, multiply and turn into the
building blocks for cartilage.
Early test results have been encouraging. "This is a
key step that moves our lab a little closer to its goal of
growing new cartilage through tissue engineering," says
Chansakul, who is known on campus by her nickname, Noon.
Chansakul, with doctoral student H. Janice Lee,
presented preliminary findings last fall during a poster
session at the annual meeting of the Biomedical Engineering
Society. Continuing to work with Lee and supported by a
PURA, Chansakul is now seeking to replicate the results for
a paper that she and Lee will submit to a peer-reviewed
scientific journal.
This is not the first time her strong science skills
have put the 21-year-old from Bangkok, Thailand, in the
spotlight. As a high school student in 2001, Chansakul
received the highest score and a golden medal in the
International Biology Olympiad, held in Brussels, Belgium,
where she competed against 150 students from 38 nations.
That achievement led to a college scholarship from the
government of Thailand. "I applied to a lot of schools,"
Chansakul says. "I came to visit Johns Hopkins, and I
really liked the biomedical engineering program and
research opportunities here."
After completing her freshman year at Johns Hopkins,
she secured a summer job working alongside other
undergraduates, graduate students and postdoctoral fellows
in Elisseeff's lab. "I was really interested in tissue
engineering," Chansakul says, "and I always wondered what
we could do with stem cells. I was interested in their
medical applications."
In her Homewood campus lab, Elisseeff, an assistant
professor of biomedical engineering, is pioneering a method
of repairing cartilage, the material found in knees, noses
and other body parts, without major surgery. The idea is to
place cells in a hydrogel, inject the liquid into the body
and then harden it with ultraviolet light. Ideally, the gel
will hold the cells in place while they multiply and
replace damaged cartilage.
To attain this goal, Elisseeff's team needs to find
the right cells and the proper medium to build new
cartilage. One strategy is to coax stem cells to turn
themselves into chondrocytes, the cells that make up
cartilage. But stem cells do not always cooperate with this
plan. Embryonic stem cells, derived from early embryos,
have the ability to replicate indefinitely and
differentiate into many cell types. Yet they do not always
survive in the lab's hydrogels, and when they do survive,
the researchers need to find the right biochemical medium
to get them to form cartilage. In contrast, mesenchymal
stem cells — adult stem cells that are more inclined
to turn into cartilage — are not plentiful enough to
complete the injury repair project on their own.
To overcome these drawbacks, Elisseeff's lab —
believed to be the only one in the country to do so —
is testing a mix of adult and embryonic stem cells, in an
effort to generate new cartilage. Chansakul is conducting
some of these experiments. "We're trying to find the best
biological conditions to increase the survival rate of
these cells and to get them to turn into the cells that
make up cartilage," she says.
Elisseeff cautions that the mice cells in Chansakul's
tests do not always behave exactly the way human cells do.
Nevertheless, Elisseeff says, the experiments do yield
useful information about the way embryonic and adult stem
cells influence one another and how well they survive in
the hydrogels.
The undergraduate research grants are helpful,
Elisseeff says, because they allow students like Chansakul
to gain important hands-on lab experience. "They're
invaluable," the faculty member says. "My students who have
gotten these awards are usually the real academic
superstars."
— Phil Sneiderman

Proteins as disease markers

Anthony Chyou is studying the role
that a certain group of proteins have in regulating salt
concentration, trafficking and acid-base balance within
cells.
PHOTO BY HPIS/WILL KIRK
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Anthony Chyou, a molecular and cell biology
major from Taipei, Taiwan, used his PURA grant to better
understand the role that a certain group of proteins known
as sodium hydrogen exchangers have in regulating salt
concentration, trafficking and acid-base balance within
cells. The research could eventually shed light on the root
causes of various diseases and conditions.
"My research is important because many diseases result
from trafficking or PH defects and affect all parts of the
human body," Chyou explains. "For example, Batten disease
affects neuronal cells, and cardiac tissue can be damaged
during recovery from ischemia."
Chyou conducted his research under the guidance of
faculty mentor Rajini Rao, a professor in the
Department of
Physiology in the School of Medicine, in whose lab he
has worked since fall 2003. Last year, Chyou aided in the
identification of an NHX1 inhibitor and relied on this and
other related experiences to carry out his PURA project,
which was titled "Role of the Endosomal Na+(K+)/H+
Exchanger, NHX1, in K28 Viral Toxin-Induced Cell Death."
"Anthony is a bright, hardworking and sincere student
who exemplifies the best of Hopkins undergraduates," Rao
says. "He is quick to learn techniques at the bench, and to
grasp concepts from our discussions. He showed admirable
initiative in putting together this proposal."
— Lisa De Nike

Tiny filaments that give bacteria their
shape

Working in the lab of Denis Wirtz,
Laura Rupprecht tests tiny filaments that give bacteria
their shape; the data may help drug makers develop new
antibiotics.
PHOTO BY HPIS/WILL KIRK
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Conducting research that may pave the way for a new
type of antibiotic, junior Laura Rupprecht used her
PURA to test a newly discovered protein filament that bends
a bacterium into a distinctive banana shape.
Using lasers, an electron microscope and other
high-tech tools, Rupprecht, a
biomedical
engineering major from St. Paul, Minn., is studying the
properties of crescentin, an intermediate filament
discovered in 2003 and thus far found only inside the
bacteria called Caulobacter crescentus.
Her work focuses on cytoskeletal proteins such as
crescentin. These strands form a web-like network inside a
bacterium, giving it shape and helping it move and divide.
In some of her experiments, Rupprecht has used a laser to
disable part of a cell's crescentin filament network, then
has recorded how quickly the network reconstructs
itself.
"All bacteria have cytoskeletal structures," she says.
"If someone can develop a new type of antibiotic that
attacks these proteins, it could disable or kill the
bacteria. But first we have to figure out how the
cytoskeletal structure works. Our experiments are a first
step in doing that."
The work is important because many bacteria are
becoming resistant to common antibiotics, which usually
work by attacking the cell wall. If vulnerabilities can be
found inside a cell, new types of antibiotics might be
made. Although crescentin, the focus of Rupprecht's
research, has been found in only one type of bacteria, some
scientists believe this filament or a similar structure
many be present in many other types of bacteria.
In her experiments, Rupprecht has been guided by
Osigwe Esue, a doctoral student in the Department of
Chemical and Biomolecular Engineering. Their findings are
reported in a paper that has been submitted to a
peer-reviewed science journal, with Rupprecht listed as a
co-author.
Their research is supervised by Denis Wirtz, a
professor in the department. Wirtz also sponsored Rupprecht
in her application for a Provost's Undergraduate Research
Award, which covered some of her laboratory costs and
living expenses while she worked in the lab last summer.
She joined Wirtz's lab just over a year ago after
hearing that it offered particularly challenging projects.
Wirtz had begun studying the newly discovered crescentin,
and Rupprecht gladly accepted the chance to assist. "I
wanted to get involved because it's such a new protein,"
she said. "We need to know how it forms cytoskeletal
structures. Then we can figure out how to dismantle it."
Rupprecht, who writes science articles for the
collegiate magazine The Triple Helix in her spare time,
said the hands-on lab experience has been invaluable. "Some
of the stuff I've been doing looks easy in textbooks," she
said. "But I've discovered that there's so much more that
can go wrong in the lab."
— Phil Sneiderman

Check Out Their Results
To recognize the
recipients of the 2005 Provost's
Undergraduate Research Awards, an event will be held on
Thursday, March 16, in Homewood's Glass Pavilion.
A poster session in which students will have an
opportunity to display the results of their research begins
at 3 p.m.
At the 4:30 p.m. recognition ceremony hosted by Steven
Knapp, provost and senior vice president for academic
affairs, the honorees will be introduced by Theodore
Poehler, vice provost for research and chair of the
selection committee.
Provost Knapp will present the students' certificates,
and PURA recipient Andrew Arceci, a student at Peabody,
will give a special presentation. "The Viola da Gamba,
Violone and the Modern Double Bass" is based on his own
research; "A Consort of Colors: The Double Reed Ensemble"
supports the PURA work of fellow Peabody student Simon
Zaleski.
A reception will follow at approximately 5:15 p.m.
The entire Johns Hopkins community is invited.
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