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The newspaper of The Johns Hopkins University September 25, 2006 | Vol. 36 No. 4
Not All Yellow Jackets Created Equal: Some Cause Worse Allergic Reactions

By Jeff Ventura
Johns Hopkins Medicine

Flouting widely held beliefs that yellow jacket stings have less effect early in the season and that most people can outgrow a dangerous allergic reaction to a sting, allergists at Johns Hopkins have concluded that the sting severity is determined not by the calendar but by the species of insect doing the stinging.

"As far as stings go, some yellow jackets are worse than others," said David Golden, an associate professor of allergy and immunology at the School of Medicine. "Because we've found that the severity of an allergic reaction is related to the species of yellow jacket, it's important for people to understand that they can have wildly different reactions depending on which species stings them and that getting stung once without an allergic reaction does not guarantee that a more serious reaction will not happen with a later sting."

Published in the Journal of Allergy and Clinical Immunology, the study by Golden and his research team involved 111 patients who had all tested allergic to yellow jackets. The researchers performed 175 test stings with two different species of yellow jackets and closely monitored the study participants for physical symptoms resulting from the stings, such as flushing, changes in vital signs, dizziness, shortness of breath and hives.

Golden's original research goal was to find out why some people have allergic reactions to stings while others do not, but over time, he said, he began to notice that subjects were having fewer reactions to a particular species of yellow jacket, leading the researchers to restructure and analyze the data they had collected at the three-year mark. They found that allergic reactions were much more common, and nastier, with the yellow jacket called Vespula maculifrons than with the one named Vespula germanica. These are the two most common species in the eastern United States, and most people can't tell them apart.

The researchers also checked whether yellow jacket stings were stronger at the end of the summer. They found that the stings in the first half of the summer caused the same number of allergic reactions as the stings in the last half of the summer. Once in July and then again in October, they also collected venoms from Vespula germanica and Vespula maculifrons, and tests showed no difference in the ability of the early- and late-summer venoms to cause allergic reactions.

The likelihood of a severe reaction was 41 percent in those who had a history of bad reactions and who were stung with Vespula maculifrons and 15 percent when stung with Vespula germanica. Those who had experienced only mild sting reactions in the past and who were stung by Vespula maculifrons had a 17 percent chance of a subsequent reaction and only a 3 percent chance when stung by Vespula germanica.

"Our results show that people who had the worst reactions in the past have the most to worry about from future stings," said Golden. "They shouldn't be fooled into thinking that they will be safe from all future stings just because they have no reaction to a particular yellow jacket sting."

Allergists recommend that those who are susceptible to severe reactions should be immunized to protect them against the allergy. Allergy shots with purified venoms (venom immunotherapy) give almost total protection from allergic reactions to stings.


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