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The newspaper of The Johns Hopkins University March 12, 2007 | Vol. 36 No. 25
Heads up to parents: Kidney disease in kids is common but treatable

During March, which is kidney awareness month, doctors at the Johns Hopkins Children's Center want to remind parents that timely detection of kidney problems in early childhood and adolescence is the best way to curb kidney damage and even reverse some of it.

"Kidney disease occurs more often than we think, but it is also more treatable than we used to think, especially when caught early," says Barbara Fivush, director of nephrology at the Children's Center. "Children and adolescents should be monitored carefully because kidney disease that seems to suddenly strike young adults often has its roots in childhood."

Kidney disease develops silently and often manifests its presence only when it's too late to stop the progressive loss in kidney function that will require dialysis or transplantation. More than one-third of kidney transplant patients in 2001 were between the ages of 20 and 44; many of them likely developed renal disease in childhood, say doctors from the Children's Center.

The telltale signs of early kidney disease are swelling (even mild) of the hands and feet and/or puffiness around the eyes; decreased or increased frequency of urination; long-lasting changes in the color and appearance of urine; and headaches resulting from high blood pressure.

"If your child has any signs or symptoms that suggest kidney disease, you should talk to your pediatrician and obtain blood studies," Fivush said.

The best way to determine kidney function is to measure glomerular filtration rate, which estimates the speed at which kidneys filter waste material from the blood. To determine GFR, doctors monitor blood levels of the substance creatinine. The higher the creatinine level, the higher the likelihood that the kidneys are not filtering at normal speed. In addition to blood tests, urinalysis can detect protein and/or blood in the urine, also signs of kidney disease.

Systemic diseases such as diabetes or lupus put children at higher risk for kidney damage.

Unrecognized kidney disease places people at greater risk for high blood pressure, heart disease and stroke. Researchers estimate that 650,000 Americans will develop end-stage renal disease by 2010, costing the health care system $28 billion a year. More than 11 percent of Americans over the age of 20 (more than 19 million) have some form of chronic kidney damage, according to recent estimates by the National Institutes of Health. Each year, about 5,000 children in the United States develop end-stage kidney disease and require a transplant.
Katerina Pesheva


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