Public Health:
Gorillas in the Midst of HIV Research
Scientists have known for years that human immunodeficiency
virus (HIV) originated in non-human primates. The question
has been, how did it get from them to us? A new study by
researchers from Johns Hopkins
Bloomberg School of Public
Health suggests an answer: bushmeat.
Nathan Wolfe, an assistant professor in the
Department of Epidemiology, and colleagues from the
School of Public Health, the Cameroon Ministry of Health,
and the Centers for Disease Control have found that people
who hunt monkeys and apes for food, known as bushmeat, can
become infected with simian foamy virus (SFV), which is in
the same class of viruses — retroviruses — as
HIV. The study, which was published in the March 20 issue
of The Lancet, documented for the first time the
transmission of SFV from primates to humans in a natural
setting.
"This research provides the first real link between
retrovirus transmission and hunting," says Wolfe, on a
phone call from Cameroon. "It supports the hypothesis that
hunting was the mechanism for HIV origins."
Working in nine Cameroonian villages, the researchers
tested blood samples from 1,099 people who had reported
having contact with non-human primates — hunting,
butchering, and in at least one case, keeping them as pets.
Ten of the people tested, or 1 percent, showed SFV
antibodies in their blood samples. Of those 10, three had
evidence of actual SFV genes in their blood cells.
Contrary to conventional wisdom, which says that
retroviruses cross the species barrier infrequently, this
study suggests that it's happening routinely. The fact that
each of the viruses had different primate origins — a
gorilla, a De Brazza's guenon, and a mandrill — is
evidence that it was three separate transmissions, says
Wolfe.
At this point, SFV has not caused harm in humans, nor has
it been shown to spread person to person. Though the
researchers are trying to determine those risks, the bigger
issue may be what this tells us about HIV — or the
next retrovirus emergence.
"There's a bit of a game-of-chance quality to this," says
Wolfe. "As the frequency and diversity of virus
transmission from animals to humans increases, so too does
the probability that one of the viruses transmitted will
have the ability to spread or cause disease."
Donald Burke, professor of
international health and epidemiology at Public Health
and one of the study's authors, points out that it's not
just retroviruses that we need to worry about. Viruses such
as avian influenza emerge when they jump from an animal to
a human, then swap genes to adapt and become a human virus
transmittable to other people. "Hopefully over the next
decade or two we can get smarter about that process and not
give [viruses] quite as many opportunities to emerge," says
Burke.
According to Wolfe, one way to do that is to decrease the
killing and butchering of bushmeat. Cameroonian villagers
are subsistence hunters, and bushmeat is the only protein
available to them. The demand for bushmeat has increased in
urban areas, and logging roads make primate habitats more
accessible — both factors that make exposure to
retroviruses more frequent. Supplying Cameroonians with
other forms of protein, says Wolfe, not only will protect
endangered monkeys and apes, it can help prevent retrovirus
emergence. "If you think about the lives and the billions
of dollars that HIV/AIDS has cost this planet," says Wolfe,
"the investment of a few million dollars to help provide
alternatives to bushmeat in these populations seems like a
very minimal investment." — CP
Art History:
Museum Liaison Builds Bonds
Johns Hopkins, the Baltimore Museum of Art, and the Walters
Art Museum have never been strangers. For years, Hopkins
professors have visited the museums with their classes, and
more than a few curators have taught courses at the
university. In recent years, this trio has gotten even
friendlier, creating internships for students, co-curating
exhibitions, and generally providing scholarly support for
each other's activities.
Now the three institutions have given their collaborations
a new boost. Hopkins, the BMA, and the Walters have jointly
hired Elizabeth Rodini to the newly created position of
museum liaison for Johns Hopkins University. Beginning July
1, it will be her job to create a more formal
collaborations program, developing interdisciplinary and
inter-institutional projects in a range of fields and
across departments and bringing in faculty and students to
work with the museums' collections. Rodini, a scholar of
Renaissance art, will also be a lecturer in Hopkins' Department of the History of Art. She
will teach her first course this fall on Italian Prints at
the BMA.