Mao Research Group
Mao Research Group
Nanoparticles for Gene Delivery   |   Stem Cell Expansion & Differentiation  |   Biomaterials Synthesis & Processing   |   Tissue Engineering & Nerve Regeneration

Selected from 74 peer-reviewed papers

Nanoparticles for Gene Delivery

  1. Roy K, Mao HQ, Huang SK, Leong KW. Oral gene delivery with chitosan-DNA nanoparticles generates immunological protection in a murine model of peanut allergy. Nature Medicine. 5(4): 387-391 (1999). [Times cited: 502-citation on Scopus].
  2. Mao HQ, Roy K, Truong-Le VL, Janes K, Lin KY, Wang Y, August JT, Leong KW. Chitosan-DNA nanoparticles as gene delivery vehicles. Journal of Controlled Release. 70(3): 399-421 (2001). [Times cited: 393]
  3. Leong KW, Mao HQ, Truong-Le VL, Roy K, Walsh SM, August JT. DNA nanospheres as non-viral gene delivery vehicles. Journal of Controlled Release. 53(1): 183-193 (1998). [Times cited: 243]
  4. Wang J, Mao HQ, Leong KW. A novel biodegradable gene carrier based on polyphosphoester. Journal of the American Chemical Society. 123(38): 9480-9481 (2001). [Times cited: 123]
  5. Wang J, Zhang PC, Mao HQ, Leong KW. Enhanced gene expression in mouse muscle by sustained release of plasmid DNA using PPE-EA as a carrier. Gene Therapy. 9(18): 1254-1261 (2002). [Times cited: 67]
  6. Wang J, Zhang PC, Lu HF, Ma N, Wang S, Mao HQ, Leong KW. New polyphosphoramidate with spermidine side chain mediates efficient gene transfer. Journal of Controlled Release. 83(1): 157-168 (2002). [Times cited: 55]
  7. Chew JL, Wolfowicz CB, Mao HQ, Leong KW, Chua KY. Chitosan nanoparticles containing plasmid DNA encoding house dust mite allergen, Der p 1 for oral vaccination in mice. Vaccine. 21(21-22): 2720-2729 (2003). [Times cited: 49]
  8. Wang J, Gao SJ, Zhang PC, Wang S, Mao HQ, Leong KW. Polyphosphoramidate gene carriers: effect of charge group on gene transfer efficiency. Gene Therapy. 11(12): 1001-1010 (2004). [Times cited: 21]
  9. Wen J, Mao HQ, Li W, Lin KY, Leong KW. Biodegradable polyphosphoester micelles for gene delivery. Journal of Pharmaceutical Sciences. 93(8): 2142-2157 (2004).
  10. Zhang XQ, Wang XL, Zhang PC, Liu Z, Zhuo RX, Mao HQ, Leong KW, Galactosylated ternary DNA/polyphosphoramidate nanoparticles mediate high gene transfection efficiency in hepatocytes, Journal of Controlled Release. 102(3): 749-763 (2005). [Times cited: 29]
  11. Jiang X, Dai H, Leong KW, Goh SH, Mao HQ, Yang YY, Chitosan-g-PEG/DNA complexes deliver gene to the rat liver via intrabiliary and intraportal infusions, Journal of Gene Medicine. 8(4): 477-487 (2006). [Times cited: 26]
  12. Dai H, Jiang X, Tan GCY, Chen Y, Torbenson MT, Leong KW, Mao HQ. Chitosan-DNA Nanoparticles Delivered by Intrabiliary Infusion Enhance Liver-Targeted Gene Delivery. International Journal of Nanomedicine. 1(4): 507-522 (2006). [Times cited: 18]
  13. Jiang X, Dai H, Ke CY, Mo X, Torbenson MS, Li Z and Mao HQ. PEG-b-PPA/DNA micelles improve transgene expression in rat liver through intrabiliary infusion. Journal of Controlled Release. 122: 297–304 (2007).
  14. Chen HH, Ho YP, Jiang X, Mao HQ, Wang TH, Leong KW. Quantitative comparison of intracellular unpacking kinetics of polyplexes by a model constructed from quantum dot-FRET. Mol Ther. 16(2):324-32 (2008). [Times cited: 23]
  15. Sun TM, Du JZ, Yan LF, Mao HQ, Wang J. Self-assembled biodegradable micellar nanoparticles of amphiphilic and cationic block copolymer for siRNA delivery. Biomaterials. 29(32):4348-55 (2008). [Times cited: 23]
  16. Jiang X, Zheng Y, Chen HH, Leong KW, Wang TH, Mao HQ. Dual-sensitive micellar nanoparticles regulate DNA unpacking and enhance gene delivery efficiency. Advanced Materials. 22(23): 2556-2560 (2010).

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Cell Expansion and Differentiation

  1. Feng Q, Chai C, Jiang XS, Leong KW, Mao HQ. Expansion of engrafting human hematopoietic stem/progenitor cells in three-dimensional scaffolds with surface-immobilized fibronectin. Journal of Biomedical Materials Research, Part A. 78(4): 781-791 (2006). [Times cited: 22]
  2. Jiang XS, Chai C, Zhang Y, Zhuo RX, Mao HQ, Leong KW. Surface-immobilization of adhesion peptides on substrate for ex vivo expansion of cryopreserved umbilical cord blood CD34+ cells. Biomaterials. 27(13): 2723-2732 (2006). [Times cited: 23]
  3. Chua KN, Chai C, Lee PC, Tang YN, Ramakrishna S, Leong KW, Mao HQ. Surface-Aminated Electrospun Nanofibers Enhance Adhesion and Expansion of Human Umbilical Cord Blood Hematopoietic Stem/Progenitor Cells. Biomaterials. 27(36): 6043-6051 (2006). [Times cited: 38]
  4. Chua KN, Chai C, Lee PC, Ramakrishna S, Leong KW, Mao HQ, Functional Nanofiber Scaffolds with Different Spacers Modulate Adhesion and Expansion of Cryopreserved Umbilical Cord Blood Hematopoietic Stem/Progenitor Cells. Experimental Hematology. 35: 771–781 (2007). [Times cited: 22]
  5. Lim SH, Mao HQ. Electrospun scaffolds for stem cell engineering. Adv Drug Deliv Rev. 61(12):1084-1096 (2009).
  6. Das H, Abdulhameed N, Joseph M, Sakthivel R, Mao HQ, Pompili VJ. Ex vivo nanofiber expansion and genetic modification of human cord blood-derived progenitor/stem cells enhances vasculogenesis. Cell Transplant. 18(3):305-18 (2009).
  7. Christopherson GT, Song H, Mao HQ. The influence of fiber diameter of electrospun substrates on neural stem cell differentiation and proliferation. Biomaterials. 30(4):556-564 (2009). [Times cited: 19]

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Biomaterials Synthesis and Processing

  1. Mao HQ, Zhuo RX, Fan CL. Synthesis and biological properties of polymer immunoadjuvants. Polymer Journal. 25(5): 499-506 (1993).
  2. Mao HQ, Zhuo RX, Fan CL, Jiang XS, Liu WP, Yi H, Studies on the phosphorylating polycondensation catalyzed by 4-dimethylaminopyridine, Macromolecular Chemistry and Physics. 196: 655-658 (1995).
  3. Leong KW, Mao HQ, Zhuo RX, Biodegradable polymers with a phosphoryl-containing backbone: tissue engineering and controlled drug delivery applications. Chinese Journal of Polymer Science. 13(4): 289-314 (1995).
  4. Zhao Z, Wang J, Mao HQ, Leong KW. Polyphosphoesters in drug and gene delivery. Advanced Drug Delivery Reviews. 55(4): 483-499 (2003). [Times cited: 76]
  5. Mao HQ, Leong KW, Design of poly(phosphoester) nanoparticles for nonviral gene therapy. Advances in Genetics. 53: 275-306 (2005).
  6. Mao HQ, Shipanova I, Zhao Z, Dang W, Brown A, Leong KW. Biodegradable poly(terephthalate-co-phosphate)s: Synthesis, characterization and drug release properties. Journal of Biomaterials Science-Polymer Edition. 16(2): 135-161 (2005).
  7. Chu LQ, Tan WJ, Mao HQ, Knoll W, Characterization of UV-induced graft polymerization of poly(acrylic acid) using optical waveguide spectroscopy. Macromolecules. 39(25): 8742-8746 (2006).
  8. Chu LQ, Mao HQ, Knoll W, In situ characterization of moisture sorption/desorption in thin polymer films using optical waveguide spectroscopy. Polymer. 47(21): 7406-7413 (2006).
  9. Fischer SE, Liu X, Mao HQ, Harden JL, Controlling cell adhesion to surfaces via associating bioactive triblock proteins. Biomaterials. 28: 3325–3337 (2007).
  10. Lin K, Chua KN, Christopherson GT, Lim S and Mao HQ, Reducing electrospun nanofiber diameter and variability using cationic amphiphiles. Polymer. 48: 6384-6394 (2007).
  11. Fischer SE, Mi L, Mao HQ, Harden JL. Biofunctional Coatings via Targeted Covalent Cross-Linking of Associating Triblock Proteins. Biomacromolecules. 10(9): 2408-2417 (2009).

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Tissue Engineering and Nerve Regeneration

  1. Chia SM, Wan ACA, Quek CH, Mao HQ, Xu X, Shen L, Ng ML, Leong KW, Yu H. Multi-layer live cell microcapsules for tissue engineering. Biomaterials. 23(3): 849-856 (2002). [Times cited: 39]
  2. Xu XY, Yu H, Mao HQ, Gao S, Leong KW, Wang S. Polyphosphoester microspheres for sustained release of biologically active nerve growth factor. Biomaterials. 23(17): 3765-3772 (2002). [Times cited: 53]
  3. Yin C, Ying L, Zhang PC, Zhuo RX, Kang ET, Leong KW, Mao HQ. High density of immobilized galactose ligand enhances hepatocyte attachment and function. Journal of Biomedical Materials Research. 67A(4): 1093-1104 (2003). [Times cited: 30]
  4. Lu HF, Lim WS, Zhang PC, Wang J, Tang ZQ, Chia SM, Yu H, Leong KW, Mao HQ, Galactosylated PVDF membrane promotes hepatocyte attachment and functional maintenance. Biomaterials. 24(27): 4893-4903 (2003). [Times cited: 31]
  5. Yin C, Chia SM, Quek CH, Yu H, Zhuo RX, Leong KW, Mao HQ. Microcapsules with improved mechanical stability for hepatocyte culture. Biomaterials. 24(10): 1771-1780 (2003). [Times cited: 35]
  6. Yin C, Liao K, Mao HQ, Leong KW, Zhuo RX, Chan V. Adhesion contact dynamics of HepG2 cells on galactose immobilized substrates. Biomaterials. 24(5): 837-850 (2003). [Times cited: 24]
  7. Ying L, Yin C, Zhuo RX, Leong KW, Mao HQ, Kang ET, Neoh KG. Immobilization of galactose ligands on acrylic acid graft-copolymerized poly(ethylene terephthalate) film and its application to hepatocyte culture. Biomacromolecules. 4(1): 157-165 (2003). [Times cited: 65]
  8. Lu HF, Chua KN, Zhang PC, Lim WS, Ramakrishna S, Leong KW, Mao HQ, Three-dimensional co-culture of rat hepatocyte spheroids and NIH/3T3 fibroblasts enhances hepatocyte functional maintenance, Acta Biomaterialia. 1(5): 399-410 (2005). [Times cited: 22]
  9. Tan WJ, Teo GP, Liao K, Leong KW, Mao HQ, Chan V. Adhesion contact dynamics of primary hepatocytes on poly(ethylene terephthalate) surface. Biomaterials. 26(8): 891-898 (2005).
  10. Chua KN, Lim WS, Zhang P, Lu H, Wen J, Ramakrishna S, Leong KW, Mao HQ. Stable immobilization of rat hepatocyte spheroids on galactosylated nanofiber scaffold. Biomaterials. 26(15): 2537-2547 (2005). [Times cited: 79]
  11. Lu HF, Lim WS, Zhang PC, Chia SM, Yu H, Mao HQ, Leong KW, Galactosylated PVDF hollow fiber bioreactor for hepatocyte culture, Tissue Engineering. 11(11-12):1667-77 (2005).
  12. Chua KN, Tang YN, Quek CH, Ramakrishna S, Leong KW, Mao HQ, Dual-functional fibrous scaffold enhances P450 activity of cultured primary rat hepatocytes. Acta Biomaterialia. 3: 643–650 (2007).

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