Recent Publications

• R. M. Linville, M. B. Sklar, G. N. Grifno, R. F. Nerenberg, J. Zhou, R. Ye, J. G. DeStefano, Z. Guo, R. Jha, J. J. Jamieson, N. Zhao, P.C. Searson. "Three-dimensional microenvironment regulates gene expression, function, and tight junction dynamics of iPSC-derived blood-brain barrier microvessels," bioRxiv (2021).
• R. M. Linville, A. Komin, X. Lan, J. G. DeStefano, C. Chu, G. Liu, P. Walczak, K. Hristova, P. C. Searson. "Reversible blood-brain barrier opening utilizing the membrane peptide melittin in vitro and in vivo," Biomaterials 275, 120942 (2021). [DOI:10.1016/j.biomaterials.2021.120942]

• D. H. Choi, M. Gonzales, G. B. Kitchen, D. T. Phan, P. C. Searson, "A Capacitative Sweat Rate Sensor for Continuous and Real-Time Monitoring of Sweat Loss," ACS Sensors 5, 3821-3826 (2020). [DOI:10.1021/acssensors.0c01219]
• R. M. Linville, D. Arevalo, J. C. Maressa, N. Zhao, P. C. Searson, "Three-dimensional induced pluripotent stem-cell models of human brain angiogenesis," Microvascular Research 132, 104042 (2020). [DOI:10.1016/j.mvr.2020.104042]
• V. L. Silvestri, E. Henriet, R. M. Linville, A. D. Wong, P. C. Searson, A. J. Ewald, "A tissue-engineered 3D microvessel model reveals the dynamics of mosaic vessel formation in breast cancer," Cancer Research 80, 4288-4301 (2020). [DOI:10.1158/0008-5472.CAN-19-1564]
• A. Komin, M. I. Bogorad, R. Lin, P. C. Searson, K. Hristova, "A peptide for transcellular cargo delivery: Structure-function relationship and mechanism of action," J Controlled Release 324, 633-643 (2020). [DOI:10.1016/j.jconrel.2020.05.0304]
• R. M. Linville, J. G. DeStefano, R. F. Nerenberg, G. N. Grifno, R. Ye, E. Gallagher, P. C. Searson, "Long-Term Cryopreservation Preserves Blood-Brain Barrier Phenotype of iPSC-Derived Brain Microvascular Endothelial Cells and Three-Dimensional Microvessels," Mol. Pharmaceutics 17, 3425-3434 (2020). [DOI:10.1021/acs.molpharmaceut.0c00484]

• R. M. Linville, J. G. DeStefano, M. B. Sklar, C. Chu, P. Walczak, P. C. Searson, "Modeling hyperosmotic blood-brain barrier opening within human tissue-engineered in vitro brain microvessels," J Cerebral Blood Flow & Metabolism ePrint (2019, [DOI:10.1177/0271678X19867980]
• M. E. Katt, L. N. Mayo, S. E. Ellis, V. Mahairaki, J. D. Rothstein, L. Cheng, and P. C. Searson, "The role of mutations associated with familial neurodegenerative disorders on blood-brain barrier function in an iPSC model," Fluids & Barriers of the CNS 16, e20 (2019). [DOI:10.1186/s12987-019-0139-4]
• J. J. Jamieson, R. M. Linville, Y. Ding, S. Gerecht, and P. C. Searson,"Role of iPSC-derived pericytes on barrier function of iPSC-derived brain microvascular endothelial cells in 2D and 3D," Fluids & Barriers of the CNS 16, e15 (2019). [DOI:10.1186/s12987-019-013]
• M. I. Bogorad*, J. G. DeStefano*, R. M. Linville*, A. D. Wong*, P. C. Searson,"Cerebrovascular plasticity: processes that lead to changes in the cerebrovascular architecture," J Cerebral Blood Flow & Metabolism 39, 1413-1432 (2019). [DOI:10.1177/0271678X19855875]
• Y. Wang, E. Gallagher, E. Troendle, D. Hu, P. C. Searson, and M. B. Ulmschneider,"An experimentally validated method to predict the blood-brain barrier permeability of small molecules using unbiased molecular dynamics simulations," Scientific Reports 9, e6117 (2019). [DOI:10.1038/s41598-019-42272-0]
• I. Jeong, D. Bychkov, and P. C. Searson, "Wearable Devices for Precision Medicine and Health State Monitoring," IEEE Trans BME 66, 1242-1258 (2019). [DOI:10.1109/TBME.2018.2871638]
• R. M. Linville, J. G. DeStefano, M. B. Sklar, Z. Xu, A. M. Farrell, M. I. Bogorad, C. Chu, P. Walczak, L. Cheng, V. Mahairaki, K. A. Whartenby, P. A. Calabresi, P. C. Searson, "Human iPSC-derived blood-brain barrier microvessels: validation of barrier function and endothelial cell behavior," Biomaterials 190-191, 24-37 (2019). [DOI:10.1016/j.biomaterials.2018.10.023]
• A. D. Wong, L. M. Russell, M. E. Katt, and P. C. Searson, "Chemotherapeutic Drug Delivery and Quantitative Analysis of Proliferation, Apoptosis, and Migration in a Tissue-Engineered 3D Microvessel Model of the Tumor Microenvironment," ACS Biomaterials Science & Engineering 5, 633−643 (2019). [DOI:10.1021/acsbiomaterials.8b00877]

• J. G. DeStefano,* J. J. Jamieson,* R. M. Linville,* and P. C. Searson, "Benchmarking in vitro tissue-engineered blood-brain barrier models," Fluids & Barriers of the CNS 15, 32 (2018). [DOI:10.1186/s12987-018-0117-2]
• E. P. Troendle, A. Khan, P. C. Searson, and M. B. Ulmschneider, "Predicting drug delivery efficiency into tumor tissues through molecular simulation of transport in complex vascular networks," J. Controlled Release 292, 2212-234 (2018). [DOI:10.1016/j.jconrel.2018.11.010]
• N. Zahradka, I. C. Jeong, and P. C. Searson, "Distinguishing positions and movements in bed from load cell signals," Physiological Measurement 39, 125001 (2018). [DOI:10.1088/1361-6579/aaeca8]
• L. Woodard, C. Dennis, J. Borchers, A. Attaluri, E. Velarde, C. Dawidczyk, P. C. Searson, M. Pomper, and R. Ivkov, "Nanoparticle architecture preserves magnetic properties during coating to enable robust multi-modal functionality," Scientific Reports 8, 12706 (2018). [DOI:10.1038/s41598-018-29711-0]
• H-J. Jang, T. Lee, J. Song, L. Russell, H. Li, J. Dailey, P. C. Searson, H. E. Katz, "Electronic Cortisol Detection Using Antibody-Embedded Polymer Coupled to a Commercial Field-effect Transistor," Applied Materials and Interfaces 10, 16233-16237 (2018). [DOI:10.1021/acsami.7b18855]
• D. H. Choi, A. Thaxton, K. Kim, I. Jeong, G. R. Cutting, P. R. Sosnay, and P. C. Searson, "Sweat Test for Cystic Fibrosis: Wearable Sweat Sensor vs. Standard Laboratory Test," Journal of Cystic Fibrosis 17, e35-e38 (2018). [DOI:10.1016/j.jcf.2018.03.005]
• M. E. Katt, R. M. Linville, L. Mayo, Z. S. Zu, P. C. Searson, "Functional brain-specific microvessels from iPSC-derived human brain microvascular endothelial cells: the role of matrix composition on monolayer formation," Fluids & Barriers of the CNS 15, e7 (2018). [DOI:10.1186/s12987-018-0092-7]
• M. E. Katt, A. D. Wong, and P. C. Searson, "Dissemination from a solid tumor: examining the multiple parallel pathways," Trends in Cancer 4, 20-37 (2018). [DOI:10.1016/j.trecan.2017.12.002]
• L. M. Russell, M. Hultz, P. C. Searson, "Leakage kinetics of the liposomal chemotherapeutic agent Doxil," J. Control. Release 269, 171-176 (2018). [DOI:10.1016/j.jconrel.2017.11.007]