Introduction to PET quantification

Class 1

Measurements in quantitative dynamic PET

Tracer time activity in plasma as input function

Metabolite correction

Calibration

Tracer tissue kinetics measured by dynamic PET as output

PET physics and quality control

data collection

data correction

Class 2

Compartment model with plasma input function

Definition of compartmental model

One-tissue compartment model

[15]O water PET

Two-tissue compartment model: parallel and sequential configuration

FDG

[68Ga]-EDTA tumor kinetics

[11C]raclopride

Compartment models of reversible and irreversible kinetics

Reversible

Irreversible

Macro- versus micro-parameters

K₁

Distribution volume

K_i

Binding potential (BP_ND)

Linear and nonlinear compartmental model for ligand-receptor binding

In vivo versus in vitro BP_ND measurements

Receptor occupancy

Class 3

Graphical analysis with plasma input function

Gjedde-Patlak plot

Logan plot

Relative equilibrium-based graphical plot (RE plot)

Multi-graphical analysis

Class 4

Spectral analysis of tissue kinetics

Spectral analysis versus compartmental model

Determination of spectral range

Class 5

Reference tissue model (RTM)

One-tissue compartment model based RTM

Two-tissue compartment model based RTM

Graphical analysis using reference tissue input

Class 6

Mathematical basis for kinetic modeling

Differential and integration operation

Matrix algebra

linear and nonlinear regression

Optimization algorithm

References

Project