Journal Articles

  • 2019

    69. Somers S, Zhang N, Morrissette-McAlmon J, Tran K, Mao H, Grayson WL, Myoblast maturity on aligned microfiber bundles at the onset of strain application impacts myogenic outcomes, Acta biomaterialia, 2019, doi:10.1016/j.actbio.2019.06.024

    68. Guo Y, Gilbert-Honick J, Somers SM, Mao H, Grayson WL, Modified cell-electrospinning for 3D myogenesis of C2C12s in aligned fibrin microfiber bundles, Biochemical and Biophysical Research Communications, 2019, doi:10.1016/j.bbrc.2019.06.082

    67. Li X, Cho B, Martin M, Seu M, Zhang C, Zhou Z, Choi JS, Jiang X, Chen L, Walia G, Yan J, Callanan M, Liu H, Colbert K, Morrissette-McAlmon J, Grayson W, Reddy S, Sacks JM, Mao H. Nanofiber-hydrogel composite-mediated angiogenesis for soft tissue reconstruction, Science Translational Medicine, 2019, doi:10.1126/scitranslmed.aau6210

    66. Rindone AN, Kachniarz B, Achebe CC, Riddle RC, O'Sullivan AN, Dorafshar AH, Grayson WL, Heparin-Conjugated Decellularized Bone Particles Promote Enhanced Osteogenic Signaling of PDGF-BB to Adipose-Derived Stem Cells in Tissue Engineered Bone Grafts, Advanced Healthcare Materials, 2019, doi:10.1002/adhm.201801565

    65. Nyberg E, Farris A, O'Sullivan A, Rodriguez R, Grayson WL, Comparison of SVF and Passaged ASCs as Point-of-Care Agents for Bone Regeneration, Tissue Engineering Part A, 2019, doi:10.1089/ten.TEA.2018.0341

  • 2018

    64. Adamo JE, Grayson WL, Hatcher H, Swanton Brown J, Thomas A, Hollister S, Steele SJ, Regulator interfaces surrounding the growing field of additive manufacturing of medical devices and biologic products, J. Clinical Translation Science, 2018, doi:10.1017/cts.2018.331

    63. Farris AL, Cook CA, Grayson WL, Mathematical Modeling of Oxygen Release From Hyperbarically-Loaded Polymers, Biotechnology Progress, doi: 10.1002/btpr.2751

    62. Salehi S, Tran K, Grayson WL, Advances in Perfusion Systems for Solid Organ Preservation, Yale Medical Journal, 2018, 91(3), 301.

    61. Gilbert-Honick J, Ginn B, Zhang Y, Salehi S, Wagner KR, Mao HQ, Grayson WL, Adipose-derived Stem/Stromal Cells on Electrospun Fibrin Microfiber Bundles Enable Moderate Muscle Reconstruction in a Volumetric Muscle Loss Model. Cell Transplantation. 2018;27(11):1644–1656.

    60. Xie E, Cook CA, Grayson WL, Benkoski J, Novel Surfactant Self-Assembly Process Generates Multi-Scale Surface Topographies for Stem Cell Growth and Differentiation, Hemijska Industrije, 2018 72(2): 69 - 80.

    59. Gilbert-Honick J, Iyer SR, Somers SM, Lovering RM, Wagner K, Mao HQ, Grayson WL, Engineering functional and histological regeneration of vascularized skeletal muscle, Biomaterials, 2018, 164:70-79

    58. Yuan D, Somers SM, Grayson WL, Spector AA, A Poroelastic model of a fibrous-porous tissue engineering scaffold, Scientific Reports, 2018, 8(1): 5043

    57. Mendez A, Rindone AN, Batra N, Abbasnia P, Senerathna J, Gil S, Hadjiabadi D, Grayson WL, Pathak A, Phenotyping the microvasculature in critical-sized calvarial defects via multimodal optical imaging, Tissue Engineering Part C, 2018, 24(7): 430 – 440

    56. Nyberg EL, Grayson WL, Assessing the minimum time period of normoxic pre-incubation for stable adipose stromal cell-derived vascular networks, Cellular & Molecular Bioengineering, 2018, 1-11

    55. Stephenson M, Grayson WL, Recent advances in bioreactors for cell-based therapies, F1000Res, 2018, F1000 Faculty Rev-517. doi: 10.12688/f1000research.12533

  • 2017

    54. Stephenson MK, Farris AL, Grayson WL, Recent Advances in Tissue Engineering Strategies for the Treatment of Joint Damage, Current Rheumatology Reports, (2017), doi:10.1007/s11926-017-0671-7

    53. Somers S, Spector A, DiGirolamo D, Grayson WL, Biophysical Stimulation for Engineering Functional Skeletal Muscle, Tissue Engineering Part B, (2017), doi:10.1089/ten.TEB.2016.0444

    52. Spector AA and Grayson WL, Stem Cell Fate Decision Making: Modeling Approaches, ACS Biomaterials Science and Engineering, (2017), doi: 10.1021/acsbiomaterials.6b00606

    51. Morrissette-McAlmon J, Blazeski A, Somers S, Kostecki G, Tung L, Grayson WL, Adipose-derived perivascular mesenchymal stromal/stem cells promote functional vascular tissue engineering for cardiac regenerative purposes, Journal of Tissue Engineering and Regenerative Medicine, (2017), doi: 10.1002/term.2418

    50. Nyberg E, Rindone A, Dorafshar A, Grayson WL, Comparison of 3D-Printed Poly-e-caprolactone Scaffolds Functionalized with Tricalcium Phosphate, Hydroxyapatite, Bio-Oss, or Decellularized Bone Matrix, Tissue Engineering Part A, (2017), doi: 10.1089/ten.TEA.2016.0418

  • 2016

    49. Nyberg EL, Farris AL, Hung BP, Dias M, Garcia JR, Dorafshar AH, Grayson WL, 3D-Printing Technologies for Craniofacial Rehabilitation, Reconstruction, and Regeneration, Annals of Biomedical Engineering, (2016), doi: 10.1007/s10439-016-1668-5

    48. Farris AL*, Rindone AN*, Grayson WL, Oxygen delivering biomaterials for tissue engineering, Journal of Materials Chemistry B, (2016), doi: 10.1039/C5TB02635K (*Authors contributed equally)

    47. Cook CA, Huri PY, Ginn BP, Gilbert‐Honick J, Somers SM, Temple JP, Mao HQ, Grayson WL, Characterization of a novel bioreactor system for 3D cellular mechanobiology studies, Biotechnology and Bioengineering, (2016), doi: 10.1002/bit.25946

    46. Hung BP, Naved BA, Nyberg EL, Dias M, Holmes CA, Elisseeff JH, Dorafshar AH, Grayson WL, Three-dimensional printing of bone extracellular matrix for craniofacial regeneration, ACS Biomaterials Science & Engineering, (2016), doi: 10.1021/acsbiomaterials.6b00101

  • 2015

    45. Hutton DH, Grayson WL, Hypoxia Inhibits De Novo Vascular Assembly of Adipose-Derived Stromal/Stem Cell Populations, but Promotes Growth of Preformed Vessels, Tissue Engineering Part A (2015), doi: 10.1089/ten.tea.2015.0421

    44. Nyberg E, Holmes C, Witham T, Grayson WL, Growth factor-eluting technologies for bone tissue engineering, Drug Delivery and Translational Research, (2015), PMID: 25967594

    42. Hung BP, Hutton DL, Kozielski KL, Bishop CJ, Naved B, Green JJ, Caplan AI, Gimble JM, Dorafshar AH, Grayson WL, Platelet-Derived Growth Factor BB Enhances Osteogenesis of Adipose-Derived But Not Bone Marrow-Derived Mesenchymal Stromal/Stem Cells, Stem Cells (2015), dio: 10.1002/stem.2060

    41. Deshpande RS, Grayson WL, Spector AA. A Modeling Insight into Adipose-Derived Stem Cell Myogenesis, PLoS One (2015), doi: 10.1371/journal.pone.0137918

    40. Cook CA, Hahn KC, Morrissette-McAlmon JBF, Grayson WL, Oxygen delivery from hyperbarically loaded microtanks extends cell viability in anoxic environments, Biomaterials (2015), doi:10.1016/j.biomaterials.2015.02.036

    39. Grayson WL, Bunnell BA, Martin E, Frazier T, Hung BP, Gimble JM, Stromal cells and stem cells in clinical bone regeneration, Nature Reviews Endocrinology, (2015), doi:10.1038/nrendo.2014.234

  • 2014

    38. Huri PY, Wang A, Spector A, Grayson WL, Multistage Adipose-Derived Stem Cell Myogenesis: An Experimental and Modeling Study, (2014), DOI: 10.1007/s12195-014-0362-7

    37. Hutton DL, Kondragunta R, Moore EM, Hung BP, Jia XF, Grayson WL, Tumor Necrosis Factor Improves Vascularization in Osteogenic Grafts Engineered with Human Adipose-derived Stem/Stromal Cells, PloS One, (2014), 9(9):e107199 doi: 10.1371/journal.pone.0107199 PMID: 25248109

    36. Huri PY, Ozilgen BA, Hutton DL, Grayson WL. Scaffold Pore Size Modulates In Vitro Osteogenesis of Human Adipose-Derived Stem/Stromal Cells. Biomedical Materials. 2014 Aug;9(4):045003. PMID: 24945873

    35. Temple JP* & Hutton DL*, Hung BP, Huri PY, Cook CA, Kondragunta R, Jia XF, Grayson WL. Engineering Anatomically Shaped Vascularized Bone Grafts with hASCs and 3D-printed Bone Scaffolds. Journal of Biomedical Materials Research, Part A. (2014) doi: 10.1002/jbm.a.35107. PMID: 24510413 (*Authors contributed equally)

    34. Zhang S, Liu X, Barreto-Ortiz SF, Yu Y, Ginn B, DeSantis N, Hutton DL, Grayson WL, Cui F, Korgel BA, Gerecht S, Mao HQ. Creating Polymer Hydrogel Microfibres with Internal Alignment via Electrical and Mechanical Stretching. Biomaterials(2014) 35(10):3243-51. PMID: 24439410

    33. Hutton DL and Grayson WL. Stem Cell-Based Regeneration of Vascularized Bone Grafts. Current Opinion in Chemical Engineering. Invited Review, (2014) 3:75-82. DOI: 10.1016/j.coche.2013.12.002

  • 2013

    32. Hung BP, Salter EK, Temple JP, Mundinger GS, Brown EN, Brazio P, Rodriguez ED, Grayson WL. Engineering Bone Grafts with Enhanced Bone Marrow and Native Scaffolds. Cells Tissues Organs. 2013 Sep 6. [Epub ahead of print]. PMID: 24021248

    31. Yilgor Huri P, Cook CA, Hutton DL, Goh BC, Gimble JM, Digirolamo DJ, Grayson WL. Biophysical cues enhance myogenesis of human adipose derived stem/stromal cells. Biochem Biophys Res Commun. 2013 Aug 16;438(1):180-5. PMID: 23876311

    30. Hutton DL, Moore EM, Gimble JM, Grayson WL. PDGF and Spatiotemporal Cues Induce Development of Vascularized Bone Tissue by Adipose-derived Stem Cells. Tissue Eng Part A. 2013 Sep;19(17-18):2076. PMID: 23582144. * Featured on the Cover *

    29. Hung BP, Hutton DL, Grayson WL. Mechanical control of tissue-engineered bone. Stem Cell Research & Therapy. 2013 Jan 31;4(1):10. PMID: 23369796

  • 2012

    28. Tzeng SY, Hung BP, Grayson WL, Green JJ. Cystamine-terminated poly(beta-amino ester)s for siRNA delivery to human mesenchymal stem cells and enhancement of osteogenic differentiation. Biomaterials. 2012 Nov;33(32):8142-51. PMID: 22871421

    27. Correia C, Grayson W, Eton R, Gimble J, Sousa R, Reis R, and Vunjak-Novakovic G. 2012, Human adipose derived cells can serve as a single cell source for the in vitro cultivation of vascularized bone grafts. J Tissue Eng Regen Med. 2012 Aug 17. [Epub ahead of print]. PMID: 22903929

    26. Marolt D, Marcos Campos I, Bhumiratana S, Koren A, Petridis P, Zhang G, Spitalnik PF, Grayson WL, and Vunjak-Novakovic G. Engineering bone tissue from human embryonic stem cells, Proceedings of the National Academy of Sciences, 2012, 109 (22) 8705-8709. PMID: 22586099

    25. Hutton DL, Logsdon EA, Moore EM, Gabhann FM, Gimble JM, Grayson WL. Vascular Morphogenesis of Adipose-Derived Stem Cells is Mediated by Heterotypic Cell-Cell Interactions. Tissue Eng Part A. 2012 Aug;18(15-16):1729-40. PMID: 22462659. * Featured on the Cover *

    24. Ghone N and Grayson WL, Recapitulating Mesenchymal Condensation Enhances Chondrogenic Differentiation of Human Mesenchymal Stem Cells, J Cell Physiol. 2012 Nov;227(11):3701-8. PMID: 22378248

    23. Salter EK, Goh B, Hung B, Hutton DL, Ghone N, and Grayson WL. Bone Tissue Engineering Bioreactors: A Role in the Clinic?. Tissue Eng Part B Rev. 2012 Feb;18(1):62-75. PMID: 21902622

  • 2011

    22. Correia C*, Grayson WL*, Park M, Hutton DL, Zhou B, Guo XE, Souza R, Reis R, and Vunjak-Novakovic G. In vitro Model of Vascularized Bone: Synergizing Vascular Development and Osteogenesis, PLoS One, 6(12):e28352 (2011) PMID:22164277

    21. Tzeng S, Yang P, Grayson WL, and Green JJ. Synthetic poly(ester amine)- and poly(amido amine)-based nanoparticles for efficient siRNA delivery and DNA delivery to human endothelial cells, International Journal of Nanomedicine, 6:3309 – 3322 (2011) PMID: 22228998

    20. Bhumiratana S, Grayson WL, Castaneda A, Rockwood D, Gil ES, Kaplan DL, Vunjak-Novakovic G. Nucleation and Growth of Mineralized Bone Matrix on Silk-Hydroxyapatite Composite Scaffolds. Biomaterials, 32:2812 – 2820 (2011) PMID: 21262535

    19. Rockwood DN, Gil ES, Park SH, Kluge JA, Grayson W, Bhumiratana S, Rajkhowa R, Wang X, Kim SJ, Vunjak-Novakovic G, Kaplan DL. Ingrowth of human mesenchymal stem cells into porous silk particle reinforced silk composite scaffolds: An in vitro study. Acta Biomaterialia. 2011 Jan;7(1):144-51. PMID: 20656075

    18. Gimble JM, Grayson WL, Guilak F, Lopez MJ and Vunjak-Novkovic G. Adipose tissue as a stem cell source for musculo-skeletal regeneration. Front Biosci (Schol Ed). 2011 Jan 1;3:69-81. PMID: 21196358

    17. Grayson WL, Marolt D, Bhumiratana S, Fröhlich M, Guo XE, Vunjak-Novakovic G. Optimizing the medium perfusion rate in bone tissue engineering bioreactors. Biotechnology & Bioengineering, 108:1159 – 1170 (2011) PMID: 21125596

  • 2010

    16. Wan LQ, Kang SM, Eng G, Grayson WL, Lu XL, Huo B, Gimble J, Guo XE, Mow VC, Vunjak-Novakovic G. Geometric control of human stem cell morphology and differentiation. Integr Biol (Camb). 2010 Aug 10;2(7-8):346-53. Epub 2010 Jul 22. PMID: 20652175

    15. Grayson WL, Bhumiratana S, Chao P-C, Hung C and Vunjak-Novakovic G. Spatial regulation of human mesenchymal stem cell differentiation in biphasic osteochondral constructs: effects of predifferentiation, soluble factors and medium perfusion. Osteoarthritis Cartilage 18 (2010),pp.714-723. PMID: 20175974

    14. Grayson WL, Frohlich M, Yeager K, Bhumiratana S, Canizzarro C, Wan LQ, Chan E, Liu X, Guo XE, Vunjak-Novakovic G. 2010. Engineering Anatomically-Shaped Human Mandibular Bone Grafts. Proceedings of the National Academy of Sciences: Special Issue in Regenerative Medicine,107(8): 3299-3304. PMID: 19820164

    13. Frohlich M, Grayson WL, Marolt D, Gimble J, Velikonja NK, and Vunjak-Novakovic G. Bone Grafts Engineered from Human Adipose-Derived Stem Cells in Perfusion Bioreactor Culture. Tissue Eng Part A. 2010 Jan:16(1):179-89. PMID: 19678762

  • 2009

    12. Zhao F, Grayson WL, Ma T, Irsigler A. 2009. Perfusion Affects the Tissue Developmental Patterns of Human Mesenchymal Stem Cells in 3D Scaffolds. J. Cell. Phys. 219: 421 - 429. PMID: 19170078

    11. Grayson WL, Martens TP, Eng GM, Radisic M and Vunjak-Novakovic G. Biomimetic approach to tissue engineering. Semin Cell Dev Biol, 20(6):665-73 (2009) PMID: 19146967

    10. Ma T, Grayson WL, Frohlich M, Vunjak-Novakovic G. Hypoxia and stem cell-based engineering of mesenchymal tissues. Biotechnol Prog, 25(1):32-42 (2009) PMID: 19198002

  • < 2009

    9. Frohlich M, Grayson WL, Wan LQ, Marolt D, Drobnic M and Vunjak-Novakovic G. Tissue engineered bone grafts: biological requirements, tissue culture and clinical relevance. Curr Stem Cell Res Ther, 3(4):254-64 (2008) PMID: 19075755

    8. Grayson WL, Bhumiratana S, Cannizzaro C, Chao PH, Lennon DP, Caplan AI and Vunjak-Novakovic G. Effects of initial seeding density and fluid perfusion rate on formation of tissue-engineered bone. Tissue Eng Part A, 14(11):1809-20 (2008) PMID: 18620487

    7. Grayson WL, Chao PH, Marolt D, Kaplan DL and Vunjak-Novakovic G. Engineering custom- designed osteochondral tissue grafts. Trends Biotechnol. 26(4):181-9 (2008) PMID: 18299159

    6. Chao PH, Grayson WL and Vunjak-Novakovic G. Engineering cartilage and bone using human mesenchymal stem cells. J Orthop Sci, 12(4):398-404 (2007) PMID: 17657563

    5. Grayson WL, Zhao F, Bunnell B and Ma T. Hypoxia enhances proliferation and tissue formation of human mesenchymal stem cells. Biochem Biophys Res Commun, 358(3):948-53 (2007) PMID: 17521616

    4. Zhao F, Grayson WL, Bunnell B, Lu WW and Ma T. Effects of Hydroxyapatite in 3-D chitosan-gelatin polymer network on human mesenchymal stem cell construct development. Biomaterials, 27:1859-67 (2006) PMID: 16225916

    3. Grayson WL, Zhao F, Bunnell B and Ma T. Effects of Hypoxia on the Development of Tissue-Engineered Constructs from Human Mesenchymal Stem Cells. J Cell Physiol, 207:331-9 (2006) PMID: 16331674

    2. Zhao F, Pathi P, Grayson WL, Xing Q, Locke BR and Ma T. Effects of Oxygen Transport on 3-D Human Mesenchymal Stem Cell Metabolic Activity in Perfusion and Static Cultures: Experiments and Mathematical Model. Biotechnol Prog, 21:1269-80 (2005) PMID: 16080711

    1. Grayson WL, Ma T and Bunnell B. Human Mesenchymal Stem Cells Tissue Development in 3D PET Matrices. Biotechnol Prog, 20:905-12 (2004) PMID: 15176898