Capturing the dance of
Proteins are the stars of the drama called life, but for
years biologists only knew them through their publicity
Researchers had developed techniques that
could reveal the finest features of how a protein was put
together, detailing the exact position of each atom in
space. But they couldn't use that information to put those
atoms in motion.
Biophysicist Ludwig Brand wanted to see
the stars in action, to find a way to record proteins as
they danced and flexed and tumbled. To detect and quantify
these split-second movements, Brand, who is a professor of
biology in the Krieger School of Arts and Sciences, helped
develop and apply a technique known as fluorescent
spectroscopy. The approach has advanced the investigation of
topics as diverse as the immune system, programmed cell
death and carbohydrate metabolism. His contributions were
recently acknowledged by the Biophysics Society, which
selected him as a Society Fellow.
SAIS dean tapped for post at
The Paul H. Nitze School of Advanced International Studies
stands to lose a gifted leader, as President George W. Bush
announced on Feb. 5 his intent to nominate Paul Wolfowitz,
the school's dean for seven years, as deputy secretary of
defense. The position requires Senate confirmation.
Wolfowitz, whose approval is expected,
will assume the No. 2 position at the Pentagon, serving
under Defense Secretary Donald H. Rumsfeld.
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