The Grayson Laboratory @ JHU

About the Lab

Our research in the Grayson Lab addresses the challenges associated with spatio-temporal control of stem cell fate in order to regenerate large composite tissue defects. We are developing innovative methods to guide stem cell differentiation patterns and create patient-specific grafts with functional biological and mechanical characteristics. We employ engineering techniques to accurately control growth factor delivery to cells in biomaterial scaffolds as well as to design advanced bioreactors capable of maintaining cell viability in large tissue constructs. These technologies are used to enable precise control of the cellular microenvironment and uniquely address fundamental questions regarding the application of biophysical cues to regulate stem cell differentiation, namely: How do the cells integrate multiple signals into decisions regarding cell fate? Can we regulate the spatial and temporal application of specific cues to recapitulate native developmental processes? What signals are required to guide the structural organization of these tissues on various length scales? Addressing the underlying mechanisms that regulate tissue development using computational and experimental tools will enable us to engineer complex functional tissue constructs for regenerative medicine applications.