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The Svetlana Lutsenko Laboratory

The research in Prof. Svetlana Lutsenko's laboratory is focused on molecular mechanisms that regulate copper concentration in normal and diseased human cells. Copper is essential for human cell homeostasis. It is required for embryonic development and neuronal function, and disruption of copper transport in human cells result in severe multi-system disorders such as Menkes disease and Wilson's disease. To understand the molecular mechanisms of copper homeostasis in normal and diseased human cells we utilize multidisciplinary approach involving biochemical and biophysical studies of molecules involved in copper transport, cell biological studies of copper signaling, and analysis of copper-induced pathologies using Wilson's disease gene knock-out mice. Email: [email protected] Office phone: 410-614-4661 Fax: 410-955-0461 B.S. (Hon.), Biochemistry, 1984 Moscow State University, Moscow, Russia Ph.D., Protein Chemistry, 1989 Institute of Bioorganic Chemistry, Moscow, Russia

Lutsenko Lab Department of Physiology Johns Hopkins University 725 N. Wolfe Street 203 Hunterian Baltimore, MD 21205 (410) 614-4661 (tel) (410) 955-0461 (fax)